| TRIM65 Suppresses oxLDL-induced Endothelial Inflammation by Interaction with VCAM-1 in Atherogenesis. | TRIM65 Suppresses oxLDL-induced Endothelial Inflammation by Interaction with VCAM-1 in Atherogenesis.
Ma XF, Zhou YR, Zhou ZX, Liu HT, Zhou BB, Deng NH, Zhou K, Tian Z, Wu ZF, Liu XY, Fu MG, Jiang ZS. | 10/25/2024 |
| TRIM65/NF2/YAP1 Signaling Coordinately Orchestrates Metabolic and Immune Advantages in Hepatocellular Carcinoma. | TRIM65/NF2/YAP1 Signaling Coordinately Orchestrates Metabolic and Immune Advantages in Hepatocellular Carcinoma.
Bian Z, Xu C, Wang X, Zhang B, Xiao Y, Liu L, Zhao S, Huang N, Yang F, Zhang Y, Xue S, Wang X, Pan Q, Sun F., Free PMC Article | 10/3/2024 |
| Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription. | Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription.
Shen S, Yan R, Xie Z, Yu X, Liang H, You Q, Zhang H, Hou J, Zhang X, Liu Y, Sun J, Guo H., Free PMC Article | 06/28/2024 |
| TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis. | TRIM65 promotes vascular smooth muscle cell phenotypic transformation by activating PI3K/Akt/mTOR signaling during atherogenesis.
Zhou ZX, Ma XF, Xiong WH, Ren Z, Jiang M, Deng NH, Zhou BB, Liu HT, Zhou K, Hu HJ, Tang HF, Zheng H, Jiang ZS. | 03/11/2024 |
| TRIM65 knockout inhibits the development of HCC by polarization tumor-associated macrophages towards M1 phenotype via JAK1/STAT1 signaling pathway. | TRIM65 knockout inhibits the development of HCC by polarization tumor-associated macrophages towards M1 phenotype via JAK1/STAT1 signaling pathway.
Jiang M, Wang D, Su N, Lou W, Chen Y, Yang H, Chen C, Xi F, Chen Y, Deng L, Tang X. | 02/13/2024 |
| TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein. | TRIM65 Promotes Malignant Cell Behaviors in Triple-Negative Breast Cancer by Impairing the Stability of LATS1 Protein.
Lu Y, Xiao Y, Yang J, Su H, Zhang X, Su F, Tian B, Zhao D, Ling X, Zhang T., Free PMC Article | 09/3/2022 |
| TRIM65 determines the fate of a novel subtype of pituitary neuroendocrine tumors via ubiquitination and degradation of TPIT. | TRIM65 determines the fate of a novel subtype of pituitary neuroendocrine tumors via ubiquitination and degradation of TPIT.
Yao H, Xie W, Dai Y, Liu Y, Gu W, Li J, Wu L, Xie J, Rui W, Ren B, Xue L, Cheng Y, Lin S, Li C, Tang H, Wang Y, Lou M, Zhang X, Hu R, Shang H, Huang J, Wu ZB., Free PMC Article | 08/6/2022 |
| Knockdown of TRIM65 suppressed the proliferation and invasiveness of gastric cancer cells by restricting the ubiquitin degradation of PPM1A. | Knockdown of TRIM65 suppressed the proliferation and invasiveness of gastric cancer cells by restricting the ubiquitin degradation of PPM1A.
Liu C, Sun W, Yang K, Xia B. | 05/21/2022 |
| TRIM65 in White Matter Lesions, Innate Immunity, and Tumor. | TRIM65 in White Matter Lesions, Innate Immunity, and Tumor.
Liu B, Tang Y, Yang P, Wu C, Huang Y. | 04/9/2022 |
| LncRNA LINC00963 promotes colorectal cancer cell proliferation and metastasis by regulating miR1281 and TRIM65. | LncRNA LINC00963 promotes colorectal cancer cell proliferation and metastasis by regulating miR‑1281 and TRIM65.
Lv H, Zhou D, Liu G., Free PMC Article | 02/12/2022 |
| TRIM65 Promotes Invasion of Endometrial Stromal Cells by Activating ERK1/2/C-myc Signaling via Ubiquitination of DUSP6. | TRIM65 Promotes Invasion of Endometrial Stromal Cells by Activating ERK1/2/C-myc Signaling via Ubiquitination of DUSP6.
Wu YT, Ma SY, Sun WQ, Shen WW, Zhu HT, Zhang Q, Chen HF. | 09/25/2021 |
| Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases.
Kato K, Ahmad S, Zhu Z, Young JM, Mu X, Park S, Malik HS, Hur S., Free PMC Article | 02/27/2021 |
| TRIM65 knockdown attenuates autophagy and cisplatin resistance in A549/DDP cells via regulating miR-138-5p. | Knockdown of TRIM65 inhibits autophagy and cisplatin resistance in A549/DDP cells by regulating miR-138-5p/ATG7.
Pan X, Chen Y, Shen Y, Tantai J., Free PMC Article | 07/11/2020 |
| this study first demonstrated that a novel LINC01857/miR-1281/TRIM65 signaling regulates glioma progression | LncRNA LINC01857 promotes growth, migration, and invasion of glioma by modulating miR-1281/TRIM65 axis.
Hu G, Liu N, Wang H, Wang Y, Guo Z. | 06/13/2020 |
| TRIM65 mediates ubiquitination of ARHGAP35, whose degradation leads to elevated Rho GTPase activity and colorectal cancer metastasis. | Ubiquitin ligase TRIM65 promotes colorectal cancer metastasis by targeting ARHGAP35 for protein degradation.
Chen D, Li Y, Zhang X, Wu H, Wang Q, Cai J, Cui Y, Liu H, Lan P, Wang J, Yang Z, Wang L., Free PMC Article | 02/1/2020 |
| Results suggest that the overexpression of tripartite motif-containing protein 65 (TRIM65) has an essential oncogenic role via ubiquitination of annexin A2 (ANXA2) in urothelial carcinoma of the bladder (UCB) pathogenesis, and that could be used as a prognostic marker and/or therapeutic target for UCB. | TRIM65 supports bladder urothelial carcinoma cell aggressiveness by promoting ANXA2 ubiquitination and degradation.
Wei WS, Chen X, Guo LY, Li XD, Deng MH, Yuan GJ, He LY, Li YH, Zhang ZL, Jiang LJ, Chen RX, Ma XD, Wei S, Ma NF, Liu ZW, Luo JH, Zhou FJ, Xie D. | 09/28/2019 |
| TRIM65 binds to the N-terminus of p53 tumor suppressor and thus competes with MDM2 for p53 binding. | Combinatory inhibition of TRIM65 and MDM2 in lung cancer cells.
Chen G, Zhou T, Liu Y, Yu Z. | 05/18/2019 |
| TRIM65 silencing inhibited cell proliferation, promoted cell apoptosis and arrested cell cycle, highly like through blocking ERK1/2 pathway. | TRIM65 is a potential oncogenic protein via ERK1/2 on Jurkat and Raji cells: A therapeutic target in human lymphoma malignancies.
Wang J, Liang X, Yu T, Xu YL, Xu LH, Zhang XJ, Ma J, Wang YR, He SL. | 12/22/2018 |
| SopA-mediated ubiquitination inhibits and triggers the proteasomal degradation of TRIM56 and TRIM65 during Salmonella infection. | Structural basis for the recognition and degradation of host TRIM proteins by Salmonella effector SopA.
Fiskin E, Bhogaraju S, Herhaus L, Kalayil S, Hahn M, Dikic I., Free PMC Article | 11/17/2018 |
| TRIM65 exerted oncogenic activities via ubiquitylation of Axin1 to activate the beta-catenin signaling pathway. | TRIM65 triggers β-catenin signaling via ubiquitylation of Axin1 to promote hepatocellular carcinoma.
Yang YF, Zhang MF, Tian QH, Zhang CZ. | 06/9/2018 |
| ARRDC4 interacted with MDA5 via the arrestin-like N domain, and further recruited TRIM65 to enhance the K63 ubiquitination of MDA5 | ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65.
Meng J, Yao Z, He Y, Zhang R, Zhang Y, Yao X, Yang H, Chen L, Zhang Z, Zhang H, Bao X, Hu G, Wu T, Cheng J., Free PMC Article | 03/10/2018 |
| TRIM65 expression is remarkably up-regulated in lung cancer tissues. Depletion of TRIM65 is able to suppress lung cancer cell proliferation, migration, invasion and adhesion. | Knockdown of TRIM65 inhibits lung cancer cell proliferation, migration and invasion: A therapeutic target in human lung cancer.
Wang XL, Shi WP, Shi HC, Lu SC, Wang K, Sun C, He JS, Jin WG, Lv XX, Zou H, Shu YS., Free PMC Article | 02/24/2018 |
| These results suggest that rs3744028 in TRIM65 is not associated with leukoaraiosis (LA) risk in the Chinese population. However, the association of rs3744028 (TRIM65) with LA before Bonferroni correction and Sidak correction is worth highlighting. | Analysis of genetic polymorphisms associated with leukoaraiosis in the southern Chinese population: A case-control study.
Huang WQ, Ye HM, Li FF, Yi KH, Zhang Y, Cai LL, Lin HN, Lin Q, Tzeng CM., Free PMC Article | 02/18/2017 |
| TRIM65 is a potential oncogenic protein, highly likely through p53 inactivation | TRIM65 negatively regulates p53 through ubiquitination.
Li Y, Ma C, Zhou T, Liu Y, Sun L, Yu Z. | 09/24/2016 |
| TRIM65 relieves miRNA-driven suppression of mRNA expression through ubiquitination and subsequent degradation of TNRC6. | TRIM65 regulates microRNA activity by ubiquitination of TNRC6.
Li S, Wang L, Fu B, Berman MA, Diallo A, Dorf ME., Free PMC Article | 07/12/2014 |