| The Neurobeachin-like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells. | The Neurobeachin-like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells.
Wegner P, Drube J, Ziegler L, Strotmann B, Marquardt R, Küchler C, Groth M, Nieswandt B, Andreas N, Drube S. | 04/8/2024 |
| The p-rpS6-zone delineates wounding responses and the healing process. | The p-rpS6-zone delineates wounding responses and the healing process.
Ring NAR, Dworak H, Bachmann B, Schädl B, Valdivieso K, Rozmaric T, Heimel P, Fischer I, Klinaki E, Gutasi A, Schuetzenberger K, Leinfellner G, Ferguson J, Drechsler S, Mildner M, Schosserer M, Slezak P, Meyuhas O, Gruber F, Grillari J, Redl H, Ogrodnik M. | 06/13/2023 |
| The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems. | The RSK2-RPS6 axis promotes axonal regeneration in the peripheral and central nervous systems.
Decourt C, Schaeffer J, Blot B, Paccard A, Excoffier B, Pende M, Nawabi H, Belin S., Free PMC Article | 05/9/2023 |
| Sleep loss drives acetylcholine- and somatostatin interneuron-mediated gating of hippocampal activity to inhibit memory consolidation. | Sleep loss drives acetylcholine- and somatostatin interneuron-mediated gating of hippocampal activity to inhibit memory consolidation.
Delorme J, Wang L, Kuhn FR, Kodoth V, Ma J, Martinez JD, Raven F, Toth BA, Balendran V, Vega Medina A, Jiang S, Aton SJ., Free PMC Article | 01/8/2022 |
| RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells. | RSK-3 promotes cartilage regeneration via interacting with rpS6 in cartilage stem/progenitor cells.
Zhang S, Hamid MR, Wang T, Liao J, Wen L, Zhou Y, Wei P, Zou X, Chen G, Chen J, Zhou G., Free PMC Article | 05/22/2021 |
| p-Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1-RPS6. | p-Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1-RPS6.
Han X, Guo J, You Y, Zhan J, Huang W. | 01/23/2021 |
| a role for phosphorylated ribosomal protein S6 (Ser235/236) (p-RPS6) in Plasmodium yoelii-infected hepatocytes. Blocking RPS6 phosphorylation prior to infection decreases the number of liver stage parasites within 24 h. | Alterations in Phosphorylation of Hepatocyte Ribosomal Protein S6 Control Plasmodium Liver Stage Infection.
Glennon EKK, Austin LS, Arang N, Kain HS, Mast FD, Vijayan K, Aitchison JD, Kappe SHI, Kaushansky A., Free PMC Article | 05/2/2020 |
| Study examined baseline levels of S6 phosphorylated at Ser235/236 (pS6Ser235/236) or Ser240/244 (pS6Ser240/244)and a possible effect of tau pathology. Findings argue against the idea that high levels of pS6Ser235/236 in neurons are a consequence of a higher expression of S6 protein and speak for an increased phosphorylation of S6 in intensely pS6Ser235/236-labeled neurons. | Analysis of ribosomal protein S6 baseline phosphorylation and effect of tau pathology in the murine brain and human hippocampus.
Klingebiel M, Dinekov M, Köhler C. | 08/12/2017 |
| in adult cardiac myocytes 4-hydroxy-trans-2-nonenal stimulates protein synthesis by activation of mTORC1-p70S6K-RPS6 signaling | The lipid peroxidation product 4-hydroxy-trans-2-nonenal causes protein synthesis in cardiac myocytes via activated mTORC1-p70S6K-RPS6 signaling.
Calamaras TD, Lee C, Lan F, Ido Y, Siwik DA, Colucci WS., Free PMC Article | 02/6/2016 |
| rpS6 phosphorylation facilitates the increase in cyclin D1 and decrease in cyclin E1 that underlie the hypertrophic nature of uninephrectomy-induced kidney growth. | Phosphorylation of ribosomal protein S6 mediates compensatory renal hypertrophy.
Xu J, Chen J, Dong Z, Meyuhas O, Chen JK., Free PMC Article | 01/30/2016 |
| The mTORC1 effectors, RPS6 and eIF4E, play distinct roles and are both necessary for AKT/Ras hepatocarcinogenesis. | 4EBP1/eIF4E and p70S6K/RPS6 axes play critical and distinct roles in hepatocarcinogenesis driven by AKT and N-Ras proto-oncogenes in mice.
Wang C, Cigliano A, Jiang L, Li X, Fan B, Pilo MG, Liu Y, Gui B, Sini M, Smith JW, Dombrowski F, Calvisi DF, Evert M, Chen X., Free PMC Article | 03/21/2015 |
| Activation of mTORC2 plays a pivotal role in cardioprotection, and Rps6 is a convergence point of cardioprotective signaling, providing positive feedback regulation of mTORC2/Akt signaling. | Pivotal role of mTORC2 and involvement of ribosomal protein S6 in cardioprotective signaling.
Yano T, Ferlito M, Aponte A, Kuno A, Miura T, Murphy E, Steenbergen C., Free PMC Article | 09/13/2014 |
| S6 phosphorylation at S240/4 is strongly cell cycle-regulated. | Phosphorylation of nuclear and cytoplasmic pools of ribosomal protein S6 during cell cycle progression.
Rosner M, Schipany K, Hengstschläger M. | 08/31/2013 |
| Data indicate that the mTOR activity evaluated by the phosphorylation status of ribosomal protein S6, and phospho-S6 (pS6) levels was found declined shortly after rapamycin treatment in both cortex and hippocampus. | The mTOR inhibitor rapamycin has limited acute anticonvulsant effects in mice.
Hartman AL, Santos P, Dolce A, Hardwick JM., Free PMC Article | 03/9/2013 |
| Downregulation of HELZ reduced translational initiation, resulting in the disassembly of polysomes, in a reduction of cell proliferation and hypophosphorylation of ribosomal protein S6. | The putative RNA helicase HELZ promotes cell proliferation, translation initiation and ribosomal protein S6 phosphorylation.
Hasgall PA, Hoogewijs D, Faza MB, Panse VG, Wenger RH, Camenisch G., Free PMC Article | 11/12/2011 |
| S240/244-phosphorylated S6 is predominantly nuclear but detectable in the cytoplasm, whereas S235/236-phosphorylated S6 is exclusively localized to the nucleus. | Different cytoplasmic/nuclear distribution of S6 protein phosphorylated at S240/244 and S235/236.
Rosner M, Fuchs C, Dolznig H, Hengstschläger M. | 05/28/2011 |
| This study establishes rpS6 phosphorylation as a determinant of muscle strength through its role in regulation of myofiber growth and energy content. | Mice deficient in ribosomal protein S6 phosphorylation suffer from muscle weakness that reflects a growth defect and energy deficit.
Ruvinsky I, Katz M, Dreazen A, Gielchinsky Y, Saada A, Freedman N, Mishani E, Zimmerman G, Kasir J, Meyuhas O., Free PMC Article | 01/21/2010 |
| the normal level of myostatin activity in mature muscle is sufficient to inhibit myofibrillar synthesis rate and phosphorylation of S6K and rpS6 | Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice.
Welle S, Burgess K, Mehta S., Free PMC Article | 01/21/2010 |
| rpS6, especially in its unphosphorylated form, is a selective mediator of TRAIL-induced apoptosis | Ribosomal protein S6 is a selective mediator of TRAIL-apoptotic signaling.
Jeon YJ, Kim IK, Hong SH, Nan H, Kim HJ, Lee HJ, Masuda ES, Meyuhas O, Oh BH, Jung YK. | 01/21/2010 |
| the phosphorylation of Tyr(1077) on LepRb during receptor activation, substantiate the hypothalamic regulation of STAT5 and S6 by leptin, and define the alternate LepRb signaling pathways | The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms.
Gong Y, Ishida-Takahashi R, Villanueva EC, Fingar DC, Münzberg H, Myers MG Jr. | 01/21/2010 |
| regulatory protein S6 phosphorylation is controlled by Akt, downstream to PI-3K and upstream to mTOR in an IL2-mediated signal transduction pathway | IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells.
Tuhácková Z, Sloncová E, Vojtechová M, Sovová V. | 01/21/2010 |
| Rps6 phosphorylation is a determinant of cell size and glucose homeostasis. | Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis.
Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, Dor Y, Zisman P, Meyuhas O., Free PMC Article | 01/21/2010 |