| ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19. | ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19.
Pietzner M, Chua RL, Wheeler E, Jechow K, Willett JDS, Radbruch H, Trump S, Heidecker B, Zeberg H, Heppner FL, Eils R, Mall MA, Richards JB, Sander LE, Lehmann I, Lukassen S, Wareham NJ, Conrad C, Langenberg C., Free PMC Article | 08/20/2022 |
| Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation. | Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation.
Miyano M, Sayaman RW, Shalabi SF, Senapati P, Lopez JC, Angarola BL, Hinz S, Zirbes A, Anczukow O, Yee LD, Sedrak MS, Stampfer MR, Seewaldt VL, LaBarge MA., Free PMC Article | 03/26/2022 |
| ELF5 inhibits the proliferation and invasion of breast cancer cells by regulating CD24. | ELF5 inhibits the proliferation and invasion of breast cancer cells by regulating CD24.
Qu X, Li Q, Tu S, Yang X, Wen W. | 01/22/2022 |
| WWOX regulates the Elf5/Snail1 pathway to affect epithelial-mesenchymal transition of ovarian carcinoma cells in vitro. | WWOX regulates the Elf5/Snail1 pathway to affect epithelial-mesenchymal transition of ovarian carcinoma cells in vitro.
Xu Y, Yan YC, Hu YK, Fang LS, Li Q, Xu J, Yan HC. | 02/13/2021 |
| Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region. | Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region.
Swahn H, Sabith Ebron J, Lamar KM, Yin S, Kerschner JL, NandyMazumdar M, Coppola C, Mendenhall EM, Leir SH, Harris A., Free PMC Article | 09/12/2020 |
| A negative correlation between ELF5, FBXW7 and IFNGR1 expression in the tumours of patients with TNBC. | Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling.
Singh S, Kumar S, Srivastava RK, Nandi A, Thacker G, Murali H, Kim S, Baldeon M, Tobias J, Blanco MA, Saffie R, Zaidi MR, Sinha S, Busino L, Fuchs SY, Chakrabarti R., Free PMC Article | 07/11/2020 |
| ELF5 alters ER-driven gene expression via ER/FOXA1 cistrome and by modulating the expression of members of the ER transcriptional complex in breast cancer cells. | ELF5 modulates the estrogen receptor cistrome in breast cancer.
Piggin CL, Roden DL, Law AMK, Molloy MP, Krisp C, Swarbrick A, Naylor MJ, Kalyuga M, Kaplan W, Oakes SR, Gallego-Ortega D, Clark SJ, Carroll JS, Bartonicek N, Ormandy CJ., Free PMC Article | 04/18/2020 |
| Authors found that expression of ELF5 was obviously decreased in ovarian cancer cell lines. The cells viability, invasion and metastasis were inhibited by overexpression ELF5. | Overexpression of E74-Like Factor 5 (ELF5) Inhibits Migration and Invasion of Ovarian Cancer Cells.
Zhang X, Lin J, Ma Y, Zhao J., Free PMC Article | 04/13/2019 |
| Elf5 expression was associated with decreased overall and disease-free survival of triple negative breast cancers patients. | Effect of the normal mammary differentiation regulator ELF5 upon clinical outcomes of triple negative breast cancers patients.
Omata F, McNamara KM, Suzuki K, Abe E, Hirakawa H, Ishida T, Ohuchi N, Sasano H. | 10/13/2018 |
| When ELF5 was transfected into the parental MCF7 cells that lack CEACAM1, lumen formation was restored, indicating that ELF5 can replace CEACAM1 in this model system of lumenogenesis. | ETS transcription factor ELF5 induces lumen formation in a 3D model of mammary morphogenesis and its expression is inhibited by Jak2 inhibitor TG101348.
Chean J, Chen CJ, Shively JE. | 10/21/2017 |
| These results support the contention that ABO expression is dependent upon a downstream positive regulatory element functioning through a tissue-restricted transcription factor, Elf5, in epithelial cells. | Epithelial Expression of Human ABO Blood Group Genes Is Dependent upon a Downstream Regulatory Element Functioning through an Epithelial Cell-specific Transcription Factor, Elf5.
Sano R, Nakajima T, Takahashi Y, Kubo R, Kobayashi M, Takahashi K, Takeshita H, Ogasawara K, Kominato Y., Free PMC Article | 05/27/2017 |
| Low ELF5 expression is associated with ovarian cancer. | ELF5 in epithelial ovarian carcinoma tissues and biological behavior in ovarian carcinoma cells.
Yan H, Qiu L, Xie X, Yang H, Liu Y, Lin X, Huang H., Free PMC Article | 04/15/2017 |
| The results of this study suggest that ELF5 is a candidate gene that confers genetic susceptibility for pediatric asthma in the Taiwanese population and SNP rs3910901 may have a minor impact on pediatric asthma in the Taiwanese population. | Polymorphisms of EHF-ELF5 genomic region and its association with pediatric asthma in the Taiwanese population.
Wang JY, Shyur SD, Lam FW, Wu LS. | 03/18/2017 |
| a novel EWSR1/ETS chimeric gene, was identified in a patient diagnosed with refractory AML, suggesting a potential role of leukemogenesis in rare cases of AML. This fusion gene is very likely to exhibit oncogenic potential by interfering with the p53/p21-dependent pathway. | EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway.
Endo A, Tomizawa D, Aoki Y, Morio T, Mizutani S, Takagi M., Free PMC Article | 02/18/2017 |
| Alternative promoter use, conferring differential regulatory responses, is the main mechanism governing ELF5 action rather than differential transcriptional activity of the isoforms. | ELF5 isoform expression is tissue-specific and significantly altered in cancer.
Piggin CL, Roden DL, Gallego-Ortega D, Lee HJ, Oakes SR, Ormandy CJ., Free PMC Article | 10/8/2016 |
| Data (including data from studies in transgenic mice) suggest that expression of ELF5 in luminal breast cancer correlates with increased myeloid cell invasion, inflammation, and lung metastasis. | ELF5 Drives Lung Metastasis in Luminal Breast Cancer through Recruitment of Gr1+ CD11b+ Myeloid-Derived Suppressor Cells.
Gallego-Ortega D, Ledger A, Roden DL, Law AM, Magenau A, Kikhtyak Z, Cho C, Allerdice SL, Lee HJ, Valdes-Mora F, Herrmann D, Salomon R, Young AI, Lee BY, Sergio CM, Kaplan W, Piggin C, Conway JR, Rabinovich B, Millar EK, Oakes SR, Chtanova T, Swarbrick A, Naylor MJ, O'Toole S, Green AR, Timpson P, Gee JM, Ellis IO, Clark SJ, Ormandy CJ., Free PMC Article | 05/14/2016 |
| we identified Elf5 as a novel biomarker of urothelial cancer on several biological levels and established a causative link between Elf5 and epithelial-mesenchymal transition in urothelial cancer. | Epigenetic regulation of Elf5 is associated with epithelial-mesenchymal transition in urothelial cancer.
Wu B, Cao X, Liang X, Zhang X, Zhang W, Sun G, Wang D., Free PMC Article | 02/6/2016 |
| Elf5 expression is inversely correlated with epithelial-mesenchymal transition in prostate cancer. | Elf5 inhibits TGF-β-driven epithelial-mesenchymal transition in prostate cancer by repressing SMAD3 activation.
Yao B, Zhao J, Li Y, Li H, Hu Z, Pan P, Zhang Y, Du E, Liu R, Xu Y. | 06/27/2015 |
| ELF5 provides a key transcriptional determinant of breast cancer molecular subtype by suppression of estrogen sensitivity in luminal breast cancer cells. | ELF5 suppresses estrogen sensitivity and underpins the acquisition of antiestrogen resistance in luminal breast cancer.
Kalyuga M, Gallego-Ortega D, Lee HJ, Roden DL, Cowley MJ, Caldon CE, Stone A, Allerdice SL, Valdes-Mora F, Launchbury R, Statham AL, Armstrong N, Alles MC, Young A, Egger A, Au W, Piggin CL, Evans CJ, Ledger A, Brummer T, Oakes SR, Kaplan W, Gee JM, Nicholson RI, Sutherland RL, Swarbrick A, Naylor MJ, Clark SJ, Carroll JS, Ormandy CJ., Free PMC Article | 05/25/2013 |
| Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2. | Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2.
Chakrabarti R, Hwang J, Andres Blanco M, Wei Y, Lukačišin M, Romano RA, Smalley K, Liu S, Yang Q, Ibrahim T, Mercatali L, Amadori D, Haffty BG, Sinha S, Kang Y., Free PMC Article | 01/26/2013 |
| Loss of ELF5 is associated with kidney cancer. | The Ets transcription factor ELF5 functions as a tumor suppressor in the kidney.
Lapinskas EJ, Svobodova S, Davis ID, Cebon J, Hertzog PJ, Pritchard MA. | 10/1/2011 |
| ELF5 is expressed in the human placenta in villous cytotrophoblast cells but not in post-mitotic syncytiotrophoblast and invasive extravillous cytotrophoblast cells. | ELF5-enforced transcriptional networks define an epigenetically regulated trophoblast stem cell compartment in the human placenta.
Hemberger M, Udayashankar R, Tesar P, Moore H, Burton GJ. | 08/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthma.
Baron RM, Palmer LJ, Tantisira K, Gabriel S, Sonna LA, Le L, Hallock A, Libermann TA, Drazen JM, Weiss ST, Silverman ES. | 03/13/2008 |
| findings show that Ese-2 upregulates K18 gene expression through specific interactions within ETS binding sites in the regulatory first intron of the gene | Epithelium-specific ets transcription factor 2 upregulates cytokeratin 18 expression in pulmonary epithelial cells through an interaction with cytokeratin 18 intron 1.
Yaniw D, Hu J., Free PMC Article | 01/21/2010 |
| Identification of the ESE-2 consensus site and characterization of the transcriptional activation properties of ESE-2 shed new light on its potential as a regulator of target genes. | Determination of the consensus DNA-binding sequence and a transcriptional activation domain for ESE-2.
Choi YS, Sinha S., Free PMC Article | 01/21/2010 |