| ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation. | ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation.
Li S, Lv J, Zhang X, Zhang Q, Li Z, Lu J, Huo X, Guo M, Liu X, Gao R, Gong J, Li C, Li W, Zhang T, Wang J, Chen Z, Du X. | 09/8/2023 |
| Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases. | Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases.
Silvestri B, Mochi M, Garone MG, Rosa A., Free PMC Article | 12/31/2022 |
| RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons. | RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons.
van der Linden RJ, Gerritsen JS, Liao M, Widomska J, Pearse RV 2nd, White FM, Franke B, Young-Pearse TL, Poelmans G., Free PMC Article | 09/17/2022 |
| ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. | ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids.
Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, Goderie SK, Chowdhury R, Lotz S, Lane K, Crary JF, Haggarty SJ, Karch CM, Ichida JK, Goate AM, Temple S., Free PMC Article | 01/8/2022 |
| HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex. | HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex.
Dell'Orco M, Sardone V, Gardiner AS, Pansarasa O, Bordoni M, Perrone-Bizzozero NI, Cereda C. | 12/11/2021 |
| ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity. | ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity.
Garone MG, Birsa N, Rosito M, Salaris F, Mochi M, de Turris V, Nair RR, Cunningham TJ, Fisher EMC, Morlando M, Fratta P, Rosa A., Free PMC Article | 12/11/2021 |
| HuB and HuD repress telomerase activity by dissociating HuR from TERC. | HuB and HuD repress telomerase activity by dissociating HuR from TERC.
Cheng X, Gu X, Xia T, Ma Z, Yang Z, Feng HL, Zhao Y, Ma W, Ju Z, Gorospe M, Yi X, Tang H, Wang W., Free PMC Article | 03/27/2021 |
| pathological mutations in FUS trigger an aberrant crosstalk with ELAVL4 with implications for Amyotrophic lateral sclerosis. | Mutant FUS and ELAVL4 (HuD) Aberrant Crosstalk in Amyotrophic Lateral Sclerosis.
De Santis R, Alfano V, de Turris V, Colantoni A, Santini L, Garone MG, Antonacci G, Peruzzi G, Sudria-Lopez E, Wyler E, Anink JJ, Aronica E, Landthaler M, Pasterkamp RJ, Bozzoni I, Rosa A., Free PMC Article | 08/1/2020 |
| HuD enhanced p27 mRNA translation by interacting with both the 5'-untranslated region (UTR) and the 3'-UTR of p27 mRNA, and consequently suppressed cell cycle progression and growth of pancreatic neuroendocrine tumors. | Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27(Kip1) levels and poor prognosis.
Kim C, Jeong DE, Heo S, Ji E, Rho JG, Jung M, Ahn S, Kim YJ, Kim YS, Nam SW, Kulkarni RN, Lee KB, Lee EK, Kim W., Free PMC Article | 10/26/2019 |
| the relative expression levels of Kv11.1 C-terminal isoforms are regulated by the RNA-binding HuR and HuD proteins | Regulation of Kv11.1 potassium channel C-terminal isoform expression by the RNA-binding proteins HuR and HuD.
Gong Q, Stump MR, Zhou Z., Free PMC Article | 04/20/2019 |
| N-myc levels appear to be modulated by the antagonistic interactions of both miR-17, as a negative regulator, and HuD, as a positive regulator in N-myc-amplified neuroblastoma cells. | Reciprocal antagonistic regulation of N-myc mRNA by miR‑17 and the neuronal-specific RNA-binding protein HuD.
Samaraweera L, Spengler BA, Ross RA., Free PMC Article | 03/31/2018 |
| The high titres of HuD in SCLC patients and preferable consistency suggested that HuD may serve as a potential diagnostic criterium for SCLC and may serve as a marker of disease progression. | Application of Serum ELAVL4 (HuD) Antigen Assay for Small Cell Lung Cancer Diagnosis.
Wang F, Lu J, Li S, Huo X, Liu X, Du X, Li C, Wang J, Chen Z. | 08/5/2017 |
| HuD binds to the APP and BACE1 3' UTRs and increases APP and BACE1 levels. | HuD regulates coding and noncoding RNA to induce APP→Aβ processing.
Kang MJ, Abdelmohsen K, Hutchison ER, Mitchell SJ, Grammatikakis I, Guo R, Noh JH, Martindale JL, Yang X, Lee EK, Faghihi MA, Wahlestedt C, Troncoso JC, Pletnikova O, Perrone-Bizzozero N, Resnick SM, de Cabo R, Mattson MP, Gorospe M., Free PMC Article | 08/22/2015 |
| study showed HuD is associated with histological grade, iffuse invasion and nodal metastasis in oral squamous cell carcinoma; it regulates expression of VEGF-A, VEGF-D, MMP-2 and MMP-9 | HuD promotes progression of oral squamous cell carcinoma.
Sasahira T, Kurihara M, Yamamoto K, Ueda N, Nakashima C, Matsushima S, Bhawal UK, Kirita T, Kuniyasu H. | 07/25/2015 |
| Phosphomimetic mutation at position Ser 221 increased nuclear HUD export. | Domain-specific phosphomimetic mutation allows dissection of different protein kinase C (PKC) isotype-triggered activities of the RNA binding protein HuR.
Schulz S, Doller A, Pendini NR, Wilce JA, Pfeilschifter J, Eberhardt W. | 12/6/2014 |
| Alzheimer's disease brain tissues with elevated neuroserpin protein also showed increased expression of THRbeta1 and HuD | Neuroserpin up-regulation in the Alzheimer's disease brain is associated with elevated thyroid hormone receptor-β1 and HuD expression.
Subhadra B, Schaller K, Seeds NW., Free PMC Article | 06/7/2014 |
| It can be involved in the pathogenesis of meningiomas in male patients. | Reduced expression of ELAVL4 in male meningioma patients.
Stawski R, Piaskowski S, Stoczynska-Fidelus E, Wozniak K, Bienkowski M, Zakrzewska M, Witusik-Perkowska M, Jaskolski DJ, Och W, Papierz W, Sikorska B, Rieske P, Liberski PP. | 03/29/2014 |
| found that p97 and its cofactor, UBXD8, destabilize p21, MKP-1, and SIRT1, three established mRNA targets of the RNA-binding protein HuR, by promoting release of HuR from mRNA | The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP.
Zhou HL, Geng C, Luo G, Lou H., Free PMC Article | 07/6/2013 |
| HuD is a pivotal regulator of insulin translation in pancreatic beta cells. | RNA-binding protein HuD controls insulin translation.
Lee EK, Kim W, Tominaga K, Martindale JL, Yang X, Subaran SS, Carlson OD, Mercken EM, Kulkarni RN, Akamatsu W, Okano H, Perrone-Bizzozero NI, de Cabo R, Egan JM, Gorospe M., Free PMC Article | 05/26/2012 |
| the endogenous function of ELAVL4 in relation to radiation sensitivity might be the regulation of cell proliferation and death | Identification of ELAVL4 as a modulator of radiation sensitivity in A549 non-small cell lung cancer cells.
Choi KJ, Lee JH, Kim KS, Kang S, Lee YS, Bae S. | 10/22/2011 |
| Complexes of HuD and Tax epitopes with HLA-A2 are close but imperfect structural mimics: alphabeta T-cell receptor with self antigens is driven to engage HuD in the same traditional binding mode as Tax. | Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics.
Borbulevych OY, Piepenbrink KH, Baker BM., Free PMC Article | 05/21/2011 |
| alterations of nELAV genes could be involved in the onset and/or progression of a subset of neuroendocrine lung tumors. | Molecular analysis of the HuD gene in neuroendocrine lung cancers.
D'Alessandro V, Muscarella LA, la Torre A, Bisceglia M, Parrella P, Scaramuzzi G, Storlazzi CT, Trombetta D, Kok K, De Cata A, Sperandeo M, Zelante L, Carella M, Vendemiale G. | 03/1/2010 |
| We found no evidence for the presence of HuD-specific T cells in the cerebrospinal fluid of patients with Hu-associated paraneoplastic neurological syndromes. | No evidence for the presence of HuD-specific T cells in the cerebrospinal fluid of patients with Hu-associated paraneoplastic neurological syndromes.
de Beukelaar JW, Milikan JC, Verjans GM, de Graaf MT, van Norden Y, Lamers CH, van den Bent MJ, Bromberg JE, Hulsenboom E, Sintnicolaas K, Gratama JW, Sillevis Smitt PA. | 01/21/2010 |
| an unregulated expression of HuD disrupts mossy fiber physiology in adult mice in part by altering the expression and phosphorylation of GAP-43 and the amount of free calmodulin available at the synaptic terminal | Alterations in mossy fiber physiology and GAP-43 expression and function in transgenic mice overexpressing HuD.
Tanner DC, Qiu S, Bolognani F, Partridge LD, Weeber EJ, Perrone-Bizzozero NI., Free PMC Article | 01/21/2010 |
| increased level of mRNA transcripts detected in Small Cell Lung Cancer patients | Molecular detection of neuron-specific ELAV-like-positive cells in the peripheral blood of patients with small-cell lung cancer.
D'Alessandro V, Muscarella LA, Copetti M, Zelante L, Carella M, Vendemiale G., Free PMC Article | 01/21/2010 |