Inhibition of the FOXO1-ROCK1 axis mitigates cardiomyocyte injury under chronic hypoxia in Tetralogy of Fallot by maintaining mitochondrial quality control.
Ren C, Xi L, Li H, Pan Z, Li Y, Wang G, Dai J, He D, Fan S, Wang Q.

Caspase-resistant ROCK1 expression prolongs survival of Eµ-Myc B cell lymphoma mice.
Mardilovich K, Naylor G, Julian L, Phinichkusolchit N, Keeshan K, Blyth K, Olson MF., Free PMC Article

ROCK1/2 signaling contributes to corticosteroid-refractory acute graft-versus-host disease.
Maas-Bauer K, Stell AV, Yan KL, de Vega E, Vinnakota JM, Unger S, Núñez N, Norona J, Talvard-Balland N, Koßmann S, Schwan C, Miething C, Martens US, Shoumariyeh K, Nestor RP, Duquesne S, Hanke K, Rackiewicz M, Hu Z, El Khawanky N, Taromi S, Andrlova H, Faraidun H, Walter S, Pfeifer D, Follo M, Waldschmidt J, Melchinger W, Rassner M, Wehr C, Schmitt-Graeff A, Halbach S, Liao J, Häcker G, Brummer T, Dengjel J, Andrieux G, Grosse R, Tugues S, Blazar BR, Becher B, Boerries M, Zeiser R., Free PMC Article

Paxillin participates in the sphingosylphosphorylcholine-induced abnormal contraction of vascular smooth muscle by regulating Rho-kinase activation.
Zhang Y, Li N, Kobayashi S., Free PMC Article

ROCK1 is a multifunctional factor maintaining the primordial follicle reserve and follicular development in mice.
Zhang T, Lin H, Ren T, He M, Zheng W, Tong Y, Jin B, Xie K, Deng A, Liu S, Chen Y, Xu G, Chen T, Pan W, Xiao Z., Free PMC Article

Inhibition of RhoA/ROCK signalling pathway activity improves neural damage and cognitive deficits in the fluorosis model.
Lingli C, Hongmei N, Penghuan J, Hongli Z, Yuye L, Rui W, Fei R, Zhihong Y, Dongfang H, Yaming G.

circROCK1 Promotes septic myocardial injury through regulating miR-96-5p/OXSR1 axis.
He Z, Xu L, Zeng X, Yang B, Liu P, Han D, Xue H, Luo B.

MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.
Pickup ME, Hu A, Patel HJ, Ahmed MI.

Klf4 deficiency exacerbates myocardial ischemia/reperfusion injury in mice via enhancing ROCK1/DRP1 pathway-dependent mitochondrial fission.
Li Y, Xiong Z, Jiang Y, Zhou H, Yi L, Hu Y, Zhai X, Liu J, Tian F, Chen Y.

ROCK1 regulates insulin secretion from β-cells.
Sung BJ, Lim SB, Yang WM, Kim JH, Kulkarni RN, Kim YB, Lee MK., Free PMC Article

CircPalm2 knockdown alleviates LPS-evoked pulmonary microvascular endothelial cell apoptosis and inflammation via miR-450b-5p/ROCK1 axis.
Mu Q, Zhang C, Li R, Guo Z.

Rho-associated, coiled-coil-containing protein kinase 1 regulates development of diabetic kidney disease via modulation of fatty acid metabolism.
Nagai Y, Matoba K, Takeda Y, Yako H, Akamine T, Sekiguchi K, Kanazawa Y, Yokota T, Sango K, Kawanami D, Utsunomiya K, Nishimura R.

Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation.
Li M, Lyu X, Liao J, Werth VP, Liu ML., Free PMC Article

Vascular smooth muscle ROCK1 contributes to hypoxia-induced pulmonary hypertension development in mice.
Penumatsa KC, Singhal AA, Warburton RR, Bear MD, Bhedi CD, Nasirova S, Wilson JL, Qi G, Preston IR, Hill NS, Fanburg BL, Kim YB, Toksoz D., Free PMC Article

LncRNA HOTAIR regulates the lipid accumulation in non-alcoholic fatty liver disease via miR-130b-3p/ROCK1 axis.
Guo B, Cheng Y, Yao L, Zhang J, Lu J, Qi H, Chen H.

Enhanced autophagy suppresses inflammation-mediated bone loss through ROCK1 signaling in bone marrow mesenchymal stem cells.
Zheng J, Gao Y, Lin H, Yuan C, Keqianzhi.

ROCK1 regulates sepsis-induced acute kidney injury via TLR2-mediated endoplasmic reticulum stress/pyroptosis axis.
Wang QL, Xing W, Yu C, Gao M, Deng LT.

EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase.
Ouchi T, Morimura S, Dow LE, Miyoshi H, Udey MC., Free PMC Article

High-expression of ROCK1 modulates the apoptosis of lens epithelial cells in age-related cataracts by targeting p53 gene.
Hu S, Su D, Sun L, Wang Z, Guan L, Liu S, Zhao B, Liu Y, Shi C, Yu J, Ma X., Free PMC Article

RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial-mesenchymal transition and proliferation in endometriosis.
Huang ZX, Mao XM, Wu RF, Huang SM, Ding XY, Chen QH, Chen QX., Free PMC Article

Metabolites of intestinal microflora upregulate miR-192-5p to suppress proliferation of colon cancer cells via RhoA-ROCK-LIMK2 pathway.
Huang YL, Li XH, Ma H, Yue HY, Hu XY.

Dendritic remodeling of D1 neurons by RhoA/Rho-kinase mediates depression-like behavior.
Fox ME, Chandra R, Menken MS, Larkin EJ, Nam H, Engeln M, Francis TC, Lobo MK., Free PMC Article

LncRNA SNHG7 promotes cardiac remodeling by upregulating ROCK1 via sponging miR-34-5p.
Wang J, Zhang S, Li X, Gong M., Free PMC Article

RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity.
Kim HJ, Kim MJ, Mostafa MN, Park JH, Choi HS, Kim YS, Choi EK., Free PMC Article

ER stress and Rho kinase activation underlie the vasculopathy of CADASIL.
Neves KB, Harvey AP, Moreton F, Montezano AC, Rios FJ, Alves-Lopes R, Nguyen Dinh Cat A, Rocchicciolli P, Delles C, Joutel A, Muir K, Touyz RM., Free PMC Article