| Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance. | Tip60-mediated Rheb acetylation links palmitic acid with mTORC1 activation and insulin resistance.
Zhao Z, Chen Q, Xiang X, Dai W, Fang W, Cui K, Li B, Liu Q, Liu Y, Shen Y, Li Y, Xu W, Mai K, Ai Q., | 10/29/2024 |
| Small G-Protein Rheb Gates Mammalian Target of Rapamycin Signaling to Regulate Morphine Tolerance in Mice. | Small G-Protein Rheb Gates Mammalian Target of Rapamycin Signaling to Regulate Morphine Tolerance in Mice.
Wang W, Ma X, Du W, Lin R, Li Z, Jiang W, Wang LY, Worley PF, Xu T. | 03/13/2024 |
| Rheb1 is required for limb growth through regulating chondrogenesis in growth plate. | Rheb1 is required for limb growth through regulating chondrogenesis in growth plate.
Zhang Y, Wen J, Lai R, Zhang J, Li K, Zhang Y, Liu A, Bai X., Free PMC Article | 03/1/2024 |
| The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function. | The mTOR pathway genes MTOR, Rheb, Depdc5, Pten, and Tsc1 have convergent and divergent impacts on cortical neuron development and function.
Nguyen LH, Xu Y, Nair M, Bordey A., Free PMC Article | 02/28/2024 |
| Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis. | Disruption of neuronal RHEB signaling impairs oligodendrocyte differentiation and myelination through mTORC1-DLK1 axis.
Huang H, Jing B, Zhu F, Jiang W, Tang P, Shi L, Chen H, Ren G, Xia S, Wang L, Cui Y, Yang Z, Platero AJ, Hutchins AP, Chen M, Worley PF, Xiao B. | 08/3/2023 |
| Adipose Rheb deficiency promotes miR-182-5p expression via the cAMP/PPARgamma signaling pathway. | Adipose Rheb deficiency promotes miR-182-5p expression via the cAMP/PPARγ signaling pathway.
Wen J, Deng J, Xiao T, Liu Y, Meng W. | 02/11/2023 |
| Deletion of Rheb1 in Osteocytes Leads to Osteopenia Characterized by Reduced Bone Formation and Enhanced Bone Resorption. | Deletion of Rheb1 in Osteocytes Leads to Osteopenia Characterized by Reduced Bone Formation and Enhanced Bone Resorption.
Yang J, Zhang W, Lai E, Liu W, Lai P, Zou Z, Wang W, Bai X. | 07/16/2022 |
| Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation. | Silencing of SmgGDS, a Novel mTORC1 Inducer That Binds to RHEBs, Inhibits Malignant Mesothelioma Cell Proliferation.
Sato T, Mukai S, Ikeda H, Mishiro-Sato E, Akao K, Kobayashi T, Hino O, Shimono W, Shibagaki Y, Hattori S, Sekido Y. | 01/29/2022 |
| HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading. | HDAC6 Negatively Regulates miR-155-5p Expression to Elicit Proliferation by Targeting RHEB in Microvascular Endothelial Cells under Mechanical Unloading.
Xu L, Zhang L, Zhang X, Li G, Wang Y, Dong J, Wang H, Hu Z, Cao X, Zhang S, Shi F., Free PMC Article | 10/30/2021 |
| RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity. | RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity.
Proietti Onori M, Koene LMC, Schäfer CB, Nellist M, de Brito van Velze M, Gao Z, Elgersma Y, van Woerden GM., Free PMC Article | 09/11/2021 |
| Circadian Rheb oscillation alters the dynamics of hepatic mTORC1 activity and mitochondrial morphology. | Circadian Rheb oscillation alters the dynamics of hepatic mTORC1 activity and mitochondrial morphology.
Yuan Q, Chen M, Yang W, Xiao B. | 07/31/2021 |
| Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain. | Persistent Rheb-induced mTORC1 activation in spinal cord neurons induces hypersensitivity in neuropathic pain.
Ma X, Du W, Wang W, Luo L, Huang M, Wang H, Lin R, Li Z, Shi H, Yuan T, Jiang W, Worley PF, Xu T., Free PMC Article | 04/24/2021 |
| RHEB gene therapy maintains the chondrogenic characteristics and protects cartilage tissue from degenerative damage during experimental murine osteoarthritis. | RHEB gene therapy maintains the chondrogenic characteristics and protects cartilage tissue from degenerative damage during experimental murine osteoarthritis.
Ashraf S, Kim BJ, Park S, Park H, Lee SH. | 09/19/2020 |
| Our study demonstrates that Rheb, by selectively modulating thermogenic gene expression in brown and beige adipose tissues, plays an important role in regulating energy homeostasis. | Rheb promotes brown fat thermogenesis by Notch-dependent activation of the PKA signaling pathway.
Meng W, Liang X, Xiao T, Wang J, Wen J, Luo H, Teng J, Fei Y, Zhang Q, Liu B, Hu F, Bai J, Liu M, Zhou Z, Liu F., Free PMC Article | 07/18/2020 |
| Rheb1 deficiency led to a progressive enlargement of the hematopoietic stem cell population and an eventual excessive myeloproliferation in vivo, including an overproduction of peripheral neutrophils and an excessive expansion of extramedullary hematopoiesis | Rheb1 loss leads to increased hematopoietic stem cell proliferation and myeloid-biased differentiation in vivo.
Wang X, Gao Y, Gao J, Li M, Zhou M, Wang J, Pang Y, Cheng H, Yuan C, Chu Y, Jiang Y, Zhou J, Luo HR, Ju Z, Cheng T, Yuan W., Free PMC Article | 05/9/2020 |
| Compensatory cardiac hypertrophy activates ER stress and ATF6, which induces RHEB and activates mTORC1. Thus, ATF6 is a previously unrecognized link between growth stimuli and mTORC1-mediated cardiac growth. | ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb.
Blackwood EA, Hofmann C, Santo Domingo M, Bilal AS, Sarakki A, Stauffer W, Arrieta A, Thuerauf DJ, Kolkhorst FW, Müller OJ, Jakobi T, Dieterich C, Katus HA, Doroudgar S, Glembotski CC., Free PMC Article | 10/26/2019 |
| These results suggest that inter-organelle communication between the Golgi and lysosome is important for mTORC1 regulation and the Golgi-localized Rheb may activate mTORC1 at Golgi-lysosome contact site. | Rheb localized on the Golgi membrane activates lysosome-localized mTORC1 at the Golgi-lysosome contact site.
Hao F, Kondo K, Itoh T, Ikari S, Nada S, Okada M, Noda T. | 08/10/2019 |
| This study found that cRheb expression promoted regeneration of injured rVRG axons into the lesion site, while we observed no rVRG axon regrowth with AAV2-GFP control. | Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI.
Urban MW, Ghosh B, Strojny LR, Block CG, Blazejewski SM, Wright MC, Smith GM, Lepore AC., Free PMC Article | 12/22/2018 |
| Rheb1 is critical for the polarization of macrophages and inhibition of allergic asthma. Deletion of Rheb1 enhances M2 polarization but decreases M1 polarization in alveolar macrophages, leading to the aggravation of OVA-induced allergic asthma. | Rheb1 deletion in myeloid cells aggravates OVA-induced allergic inflammation in mice.
Li K, Zhang Y, Liang KY, Xu S, Zhou XJ, Tan K, Lin J, Bai XC, Yang CL., Free PMC Article | 11/3/2018 |
| Ggpps deletion enhanced Rheb farnesylation, which subsequently activated mTORC1 and facilitated spermatogonial differentiation | Alteration of protein prenylation promotes spermatogonial differentiation and exhausts spermatogonial stem cells in newborn mice.
Diao F, Jiang C, Wang XX, Zhu RL, Wang Q, Yao B, Li CJ., Free PMC Article | 07/7/2018 |
| Thus, the various regulatory elements that impinge upstream of mTORC1 activation pathways are differentially required for HSC homeostasis in vivo. | Distinct roles of Rheb and Raptor in activating mTOR complex 1 for the self-renewal of hematopoietic stem cells.
Peng H, Kasada A, Ueno M, Hoshii T, Tadokoro Y, Nomura N, Ito C, Takase Y, Vu HT, Kobayashi M, Xiao B, Worley PF, Hirao A. | 12/30/2017 |
| Forebrain depletion of Rheb GTPase elicits spatial memory deficits. | Forebrain depletion of Rheb GTPase elicits spatial memory deficits in mice.
Shahani N, Huang WC, Varnum M, Page DT, Subramaniam S., Free PMC Article | 10/7/2017 |
| Rheb is an important negative regulator of beige fat development and thermogenesis. Rheb is able to suppress the beiging effect through an mTORC1-independent mechanism, via PDE4D5-dependent downregulation of the cAMP-PKA signaling pathway. | Rheb Inhibits Beiging of White Adipose Tissue via PDE4D5-Dependent Downregulation of the cAMP-PKA Signaling Pathway.
Meng W, Liang X, Chen H, Luo H, Bai J, Li G, Zhang Q, Xiao T, He S, Zhang Y, Xu Z, Xiao B, Liu M, Hu F, Liu F., Free PMC Article | 08/19/2017 |
| Rheb and TSC2 have roles in the mechanical activation of mTOR signaling | Identification of mechanically regulated phosphorylation sites on tuberin (TSC2) that control mechanistic target of rapamycin (mTOR) signaling.
Jacobs BL, McNally RM, Kim KJ, Blanco R, Privett RE, You JS, Hornberger TA., Free PMC Article | 07/15/2017 |
| Rheb1 is critical for macrophage production and phagocytosis and executes these activities possibly via mTORC1-dependent pathway. | Rheb1-mTORC1 maintains macrophage differentiation and phagocytosis in mice.
Wang X, Li M, Gao Y, Gao J, Yang W, Liang H, Ji Q, Li Y, Liu H, Huang J, Cheng T, Yuan W. | 05/13/2017 |