| Disruption of DNA polymerase zeta engages an innate immune response. | Disruption of DNA polymerase ζ engages an innate immune response.
Martin SK, Tomida J, Wood RD., Free PMC Article | 01/29/2022 |
| The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair. | The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair.
Adeyemi RO, Willis NA, Elia AEH, Clairmont C, Li S, Wu X, D'Andrea AD, Scully R, Elledge SJ., Free PMC Article | 01/8/2022 |
| The role of DNA polymerase zeta in benzo[a]pyrene-induced mutagenesis in the mouse lung. | The role of DNA polymerase ζ in benzo[a]pyrene-induced mutagenesis in the mouse lung.
Ishii Y, Takasu S, Grúz P, Masumura K, Ogawa K, Nohmi T, Umemura T. | 12/18/2021 |
| DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability. | DNA polymerase zeta contributes to heterochromatin replication to prevent genome instability.
Ben Yamin B, Ahmed-Seghir S, Tomida J, Despras E, Pouvelle C, Yurchenko A, Goulas J, Corre R, Delacour Q, Droin N, Dessen P, Goidin D, Lange SS, Bhetawal S, Mitjavila-Garcia MT, Baldacci G, Nikolaev S, Cadoret JC, Wood RD, Kannouche PL., Free PMC Article | 12/18/2021 |
| A large intermediate domain of vertebrate REV3 protein is dispensable for ultraviolet-induced translesion replication. | A large intermediate domain of vertebrate REV3 protein is dispensable for ultraviolet-induced translesion replication.
Takezawa J, Shimazaki A, Takimoto H, Kajiwara K, Yamada K. | 08/7/2021 |
| The roles of POLZ in DNA replication and repair have been summarized. (Review) | DNA polymerase ζ in DNA replication and repair.
Martin SK, Wood RD., Free PMC Article | 12/14/2019 |
| Following challenge with AFB1, survival of mouse cells deficient in pol zeta (Rev3L(-/-)) was significantly reduced relative to Rev3L(+/-) cells or Rev3L(-/-) cells complemented through expression of the wild-type human REV3L | DNA polymerase ζ limits chromosomal damage and promotes cell survival following aflatoxin exposure.
Lin YC, Owen N, Minko IG, Lange SS, Tomida J, Li L, Stone MP, Wood RD, McCullough AK, Lloyd RS., Free PMC Article | 03/31/2018 |
| A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro. | A single aspartate mutation in the conserved catalytic site of Rev3L generates a hypomorphic phenotype in vivo and in vitro.
Fritzen R, Delbos F, De Smet A, Palancade B, Canman CE, Aoufouchi S, Weill JC, Reynaud CA, Storck S. | 05/20/2017 |
| the functions of REV3L in maintaining cell viability, embryonic viability and genomic stability are directly dependent on its polymerase activity, and cannot be ameliorated by an additional deletion of pol eta | The Polymerase Activity of Mammalian DNA Pol ζ Is Specifically Required for Cell and Embryonic Viability.
Lange SS, Tomida J, Boulware KS, Bhetawal S, Wood RD., Free PMC Article | 05/14/2016 |
| results can be unified by a model in which slowly dividing cells accumulate replication-associated DNA breaks but otherwise survive Rev3L deletion, but functional polzeta is essential for responses requiring rapid proliferation | Dual role for mammalian DNA polymerase ζ in maintaining genome stability and proliferative responses.
Lange SS, Bedford E, Reh S, Wittschieben JP, Carbajal S, Kusewitt DF, DiGiovanni J, Wood RD., Free PMC Article | 04/27/2013 |
| Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) zeta, and Pol kappa | Structural basis of Rev1-mediated assembly of a quaternary vertebrate translesion polymerase complex consisting of Rev1, heterodimeric polymerase (Pol) ζ, and Pol κ.
Wojtaszek J, Lee CJ, D'Souza S, Minesinger B, Kim H, D'Andrea AD, Walker GC, Zhou P., Free PMC Article | 12/22/2012 |
| DNA polymerase zeta generates tandem mutations in immunoglobulin variable regions | DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions.
Saribasak H, Maul RW, Cao Z, Yang WW, Schenten D, Kracker S, Gearhart PJ., Free PMC Article | 08/18/2012 |
| Pol zeta was determined to be necessary for proliferation of normal cells using conditions in which Rev3L could be conditionally inactivated by Cre recombinase. | DNA polymerase zeta is required for proliferation of normal mammalian cells.
Lange SS, Wittschieben JP, Wood RD., Free PMC Article | 08/4/2012 |
| REV7 subunit of pol zeta mediated the interaction between REV3 and the REV1 C terminus. | The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.
Hashimoto K, Cho Y, Yang IY, Akagi J, Ohashi E, Tateishi S, de Wind N, Hanaoka F, Ohmori H, Moriya M., Free PMC Article | 06/16/2012 |
| In the presence of reduced levels of Rev3, an essential component of Polzeta, tumors exhibited pronounced sensitivity to cisplatin, leading to a significant extension in overall survival of treated recipient mice. | Suppression of Rev3, the catalytic subunit of Pol{zeta}, sensitizes drug-resistant lung tumors to chemotherapy.
Doles J, Oliver TG, Cameron ER, Hsu G, Jacks T, Walker GC, Hemann MT., Free PMC Article | 01/8/2011 |
| found that Rev3 is important for a post-replication repair pathway of helix-distorting [6-4]pyrimidine-pyrimidone photoproducts | Mammalian polymerase zeta is essential for post-replication repair of UV-induced DNA lesions.
Jansen JG, Tsaalbi-Shtylik A, Hendriks G, Verspuy J, Gali H, Haracska L, de Wind N. | 02/8/2010 |
| Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. | Pol zeta ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability.
Schenten D, Kracker S, Esposito G, Franco S, Klein U, Murphy M, Alt FW, Rajewsky K., Free PMC Article | 01/21/2010 |
| REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated PCNA | REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated proliferating cell nuclear antigen (PCNA).
Shen X, Jun S, O'Neal LE, Sonoda E, Bemark M, Sale JE, Li L. | 01/21/2010 |
| Immortalized mouse cell lines that lack a functional Rev3 gene are hypersensitive to UV irradiation and cisplatin treatment. | Immortalized mouse cell lines that lack a functional Rev3 gene are hypersensitive to UV irradiation and cisplatin treatment.
Zander L, Bemark M. | 01/21/2010 |
| Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage | Involvement of mouse Rev3 in tolerance of endogenous and exogenous DNA damage.
Van Sloun PP, Varlet I, Sonneveld E, Boei JJ, Romeijn RJ, Eeken JC, De Wind N., Free PMC Article | 01/21/2010 |
| data support a central role for DNA polymerase eta in the error-free bypass of UV photoproducts | Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta.
Diaz M, Watson NB, Turkington G, Verkoczy LK, Klinman NR, McGregor WG. | 01/21/2010 |
| An essential role for REV3 in cell survival: absence of REV3 induces p53-independent embryonic death | An essential role for REV3 in mammalian cell survival: absence of REV3 induces p53-independent embryonic death.
O-Wang J, Kajiwara K, Kawamura K, Kimura M, Miyagishima H, Koseki H, Tagawa M. | 01/21/2010 |