| Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia. | Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia.
Getz TE, Chrenek MA, Papania JT, Shelton DA, Markand S, Iuvone PM, Kozmik Z, Boatright JH, Nickerson JM., Free PMC Article | 06/30/2024 |
| These data demonstrate distinguishing features of retinal inflammation and T-cell immune responses involved in IRBP-induced EAU between B10.RIII and C57BL/6 strains. | Comparative Analysis of the Interphotoreceptor Retinoid Binding ProteinInduced Models of Experimental Autoimmune Uveitis in B10.RIII versus C57BL/6 Mice.
Chen Y, Chen Z, Chong WP, Wu S, Wang W, Zhou H, Chen J. | 10/5/2019 |
| The 629-643 RBP-3 peptide is a major uveitogenic peptide for the induction of autoimmune uveoretinitis in C57BL/6J mice and the persistent clinical disease induced with one peptide leads to epitope spreading. | A novel pathogenic RBP-3 peptide reveals epitope spreading in persistent experimental autoimmune uveoretinitis.
Boldison J, Khera TK, Copland DA, Stimpson ML, Crawford GL, Dick AD, Nicholson LB., Free PMC Article | 12/19/2015 |
| We propose that down-regulation of IRBP may represent an early and novel pathogenic mechanism in degenerative retinal diseases | Dysregulation of inter-photoreceptor retinoid-binding protein (IRBP) after induced Müller cell disruption.
Zhu L, Shen W, Lyons B, Wang Y, Zhou F, Gillies MC. | 09/5/2015 |
| Although death signaling proteins are increased, the caspase-dependent and independent apoptotic pathways are mildly activated in Irbp-deficient retinas. | Receptor interacting protein kinase-mediated necrosis contributes to cone and rod photoreceptor degeneration in the retina lacking interphotoreceptor retinoid-binding protein.
Sato K, Li S, Gordon WC, He J, Liou GI, Hill JM, Travis GH, Bazan NG, Jin M., Free PMC Article | 12/28/2013 |
| Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP). | Secretory defect and cytotoxicity: the potential disease mechanisms for the retinitis pigmentosa (RP)-associated interphotoreceptor retinoid-binding protein (IRBP).
Li S, Yang Z, Hu J, Gordon WC, Bazan NG, Haas AL, Bok D, Jin M., Free PMC Article | 06/15/2013 |
| In addition to its role in the visual cycle, IRBP is needed for normal eye development. | Exaggerated eye growth in IRBP-deficient mice in early development.
Wisard J, Faulkner A, Chrenek MA, Waxweiler T, Waxweiler W, Donmoyer C, Liou GI, Craft CM, Schmid GF, Boatright JH, Pardue MT, Nickerson JM., Free PMC Article | 10/1/2011 |
| IRBP is essential to normal cone function and demonstrate that differences exist in the visual cycle of rods and cones. | The interphotoreceptor retinoid binding (IRBP) is essential for normal retinoid processing in cone photoreceptors.
Parker RO, Crouch RK. | 09/17/2011 |
| these findings suggest that IRBP plays an important role in the delivery of 11-cis-retinol to cones and can facilitate cone function in the presence of light | Interphotoreceptor retinoid-binding protein as the physiologically relevant carrier of 11-cis-retinol in the cone visual cycle.
Parker R, Wang JS, Kefalov VJ, Crouch RK., Free PMC Article | 05/28/2011 |
| Activation of IRBP-specific T cells from mice immunized with uveitogenic IRBP(1-20) peptide under T-helper cell interleukin (IL)17-polarizing conditions is associated with increased expansion of T cells expressing the gamma delta T cell receptor. | Major role of gamma delta T cells in the generation of IL-17+ uveitogenic T cells.
Cui Y, Shao H, Lan C, Nian H, O'Brien RL, Born WK, Kaplan HJ, Sun D., Free PMC Article | 01/21/2010 |
| Data indicate that IRBP is essential to normal cone function and demonstrate that IRBP has a cone-specific visual cycle function. | Normal cone function requires the interphotoreceptor retinoid binding protein.
Parker RO, Fan J, Nickerson JM, Liou GI, Crouch RK., Free PMC Article | 01/21/2010 |
| data show that presence of IRBP is necessary in ocular and pineal gland tissues for expression of autoimmune uveitis | Interphotoreceptor retinoid-binding protein (IRBP)-deficient C57BL/6 mice have enhanced immunological and immunopathogenic responses to IRBP and an altered recognition of IRBP epitopes.
Avichezer D, Liou GI, Chan CC, Lewis GM, Wiggert B, Donoso LA, Nickerson JM, Crawford MA, Caspi RR. | 01/21/2010 |
| Expression of IRBP within the thymus is critical to prevent spontaneous autoimmunity against the eye, even in the presence of autoimmune regulator aire. | Spontaneous autoimmunity prevented by thymic expression of a single self-antigen.
DeVoss J, Hou Y, Johannes K, Lu W, Liou GI, Rinn J, Chang H, Caspi RR, Fong L, Anderson MS., Free PMC Article | 01/21/2010 |
| analysis of the structure and sequence of the IRBP gene | Sequence analysis of the mouse IRBP gene and cDNA.
Shuler RK Jr, Gross E, He WY, Liou GI, Nickerson JM. | 01/21/2010 |
| Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells. | Tumor formation in mice with somatic inactivation of the retinoblastoma gene in interphotoreceptor retinol binding protein-expressing cells.
Vooijs M, te Riele H, van der Valk M, Berns A. | 01/21/2010 |