| Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis. | Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis.
Grande J, Jones TL, Sun Z, Chanana P, Jaiswal I, Leontovich A, Carapanceanu N, Carapanceanu V, Saadalla A, Osman A, Famuyide AO, Daftary GS, Khan Z, Khazaie K. | 08/9/2023 |
| Genetic deletion of Kruppel-like factor 11 aggravates traumatic brain injury. | Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury.
Zhou C, Sun P, Hamblin MH, Yin KJ., Free PMC Article | 11/29/2022 |
| KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction. | KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction.
De Lorenzo SB, Vrieze AM, Johnson RA, Lien KR, Nath KA, Garovic VD, Khazaie K, Grande JP., Free PMC Article | 04/23/2022 |
| Endothelium-targeted overexpression of Kruppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury. | Endothelium-targeted overexpression of Krüppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury.
Zhang X, Tang X, Ma F, Fan Y, Sun P, Zhu T, Zhang J, Hamblin MH, Chen YE, Yin KJ., Free PMC Article | 06/26/2021 |
| Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFbeta inducible early gene-1 knockout female mice. | Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene-1 knockout female mice.
Gingery A, Subramaniam M, Pitel KS, Li X, Ke HZ, Turner RT, Iwaniec UT, Hawse JR., Free PMC Article | 03/13/2021 |
| Vascular smooth muscle cell-specific Klf11 knockout mice exhibited significantly reduced occlusion time.KLF11 is a novel transcriptional suppressor of F3 in vascular smooth muscle cells. KLF11 downregulates F3 at the transcriptional level as determined by reporter and chromatin immunoprecipitation assays. | KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall.
Liang W, Fan Y, Lu H, Chang Z, Hu W, Sun J, Wang H, Zhu T, Wang J, Adili R, Garcia-Barrio MT, Holinstat M, Eitzman D, Zhang J, Chen YE., Free PMC Article | 01/18/2020 |
| KLF11 acts as a novel protective factor in ischemic stroke. | Genetic Deletion of Krüppel-Like Factor 11 Aggravates Ischemic Brain Injury.
Tang X, Liu K, Hamblin MH, Xu Y, Yin KJ., Free PMC Article | 02/16/2019 |
| Consistent with loss of Klf11-mediated activation, lesions in Klf11-/- animals were associated with progressive fibrosis and decreased Drd2 expression. | KLF11 is an Epigenetic Mediator of DRD2/Dopaminergic Signaling in Endometriosis.
Richards EG, Zheng Y, Shenoy CC, Ainsworth AJ, Delaney AA, Jones TL, Khan Z, Daftary GS. | 04/28/2018 |
| Using a sterile peritonitis model, fibrosis selectively developed in Klf11-/- females. Fibrosis in these animals was almost completely abrogated by ovariectomy. Ovariectomized animals were selectively supplemented with estradiol, medroxyprogesterone acetate (MPA), or dihydrotestosterone; fibrosis was only observed in mice exposed to MPA. | Progressive Fibrosis: A Progesterone- and KLF11-Mediated Sexually Dimorphic Female Response.
Shenoy CC, Khan Z, Zheng Y, Jones TL, Khazaie K, Daftary GS. | 10/21/2017 |
| TGFbeta and KLF11 mediate critical, translationally relevant host and lesion-driven responses that enable establishment and progression of endometriosis. | TGF-β Induces Endometriotic Progression via a Noncanonical, KLF11-Mediated Mechanism.
Correa LF, Zheng Y, Delaney AA, Khan Z, Shenoy CC, Daftary GS. | 07/1/2017 |
| Results suggest a role for KLF11 in upregulating MAO-A in depressive disorder and chronic social stress, suggesting that inhibition of the pathways regulated by this transcription factor may aid in the therapeutics of neuropsychiatric illnesses | Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders.
Harris S, Johnson S, Duncan JW, Udemgba C, Meyer JH, Albert PR, Lomberk G, Urrutia R, Ou XM, Stockmeier CA, Wang JM., Free PMC Article | 04/2/2016 |
| Data show that the major phenotype given by the whole-body deletion of Kruppel-like factor 11 (Klf11) is not diabetes but increased insulin sensitivity. | Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.
Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R., Free PMC Article | 01/16/2016 |
| Loss of KLF11 expression is associated with hyperglycemia in Type 2 diabetes. | Involvement of KLF11 in hepatic glucose metabolism in mice via suppressing of PEPCK-C expression.
Zhang H, Chen Q, Jiao T, Cui A, Sun X, Fang W, Xie L, Liu Y, Fang F, Chang Y., Free PMC Article | 03/7/2015 |
| this study revealed a new role for the KLF11 gene in the mechanisms underlying the antinociceptive effects of chronic ethanol exposure | Diabetes-causing gene, kruppel-like factor 11, modulates the antinociceptive response of chronic ethanol intake.
Ou XM, Udemgba C, Wang N, Dai X, Lomberk G, Seo S, Urrutia R, Wang J, Duncan J, Harris S, Fairbanks CA, Zhang X., Free PMC Article | 10/4/2014 |
| KLF11 is a critical transcription factor in the function of mesenchymal cells and, specifically, as a negative regulator of collagen secretion. | Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis.
Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, Hendrickson H, Liebl A, Xiong YY, Gores G, Fernandez-Zapico M, Larusso NF, Faubion W, Shah VH, Urrutia R., Free PMC Article | 06/21/2014 |
| Taken together, our findings identify a novel anti-hypertrophic and anti-fibrotic role of KLF11, and KLF11 activator may serve as candidate drug for heart failure patients. | Krüppel-like transcription factor 11 (KLF11) overexpression inhibits cardiac hypertrophy and fibrosis in mice.
Zheng Y, Kong Y, Li F. | 03/15/2014 |
| Overexpression of KLF11 in the livers of diabetic and obese mice activates the PPARalpha signaling pathway, subsequently markedly improving the fatty liver phenotype. Knockdown of KLF11 increases hepatic triglycerides. | Mouse KLF11 regulates hepatic lipid metabolism.
Zhang H, Chen Q, Yang M, Zhu B, Cui Y, Xue Y, Gong N, Cui A, Wang M, Shen L, Zhang S, Fang F, Chang Y. | 01/25/2014 |
| Data identify a novel pathogenic role for KLF11 in preventing de novo disease-associated fibrosis in endometriosis. | A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis.
Daftary GS, Zheng Y, Tabbaa ZM, Schoolmeester JK, Gada RP, Grzenda AL, Mathison AJ, Keeney GL, Lomberk GA, Urrutia R., Free PMC Article | 10/19/2013 |
| Recruitment of KLF11 as a novel co-regulator (with peroxisome proliferator-activated receptor PPARgamma) plays a critical role in cerebrovascular protection after ischemic insults. | KLF11 mediates PPARγ cerebrovascular protection in ischaemic stroke.
Yin KJ, Fan Y, Hamblin M, Zhang J, Zhu T, Li S, Hawse JR, Subramaniam M, Song CZ, Urrutia R, Lin JD, Chen YE., Free PMC Article | 06/1/2013 |
| Kruppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-kappaB signaling pathway. | Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-κB signaling pathway.
Fan Y, Guo Y, Zhang J, Subramaniam M, Song CZ, Urrutia R, Chen YE., Free PMC Article | 02/2/2013 |
| KLF11 is an MAO A regulator and is produced in response to neuronal stress, which transcriptionally activates MAO A. | Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression.
Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert PR, Stockmeier CA, Meyer JH, Urrutia R, Miczek KA, Austin MC, Wang J, Paul IA, Woolverton WL, Seo S, Sittman DB, Ou XM., Free PMC Article | 09/29/2012 |
| an important role for KLF11 in the regulation of INS transcription via the novel c.-331 KLF site. | Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus.
Bonnefond A, Lomberk G, Buttar N, Busiah K, Vaillant E, Lobbens S, Yengo L, Dechaume A, Mignot B, Simon A, Scharfmann R, Neve B, Tanyolaç S, Hodoglugil U, Pattou F, Cavé H, Iovanna J, Stein R, Polak M, Vaxillaire M, Froguel P, Urrutia R., Free PMC Article | 05/12/2012 |
| the expression of TIEG1 and TIEG2 was specific in different organs yet varied with different developmental time points. | Dynamic transcriptional changes of TIEG1 and TIEG2 during mouse tissue development.
Jiang L, Chen Y, Chan CY, Lu G, Wang H, Li JC, Kung HF. | 08/16/2010 |
| Tieg3/Klf11 is a downstream mediator of TGF-beta-induced apoptosis in the oligodendroglial cell line OLI-neu by transcriptional repression of Smad7 | Tieg3/Klf11 induces apoptosis in OLI-neu cells and enhances the TGF-beta signaling pathway by transcriptional repression of Smad7.
Gohla G, Krieglstein K, Spittau B. | 01/21/2010 |
| KLF11 is downregulated in human cancers, inhibits cell growth in vitro and in vivo, and suppresses neoplastic transformation | An mSin3A interaction domain links the transcriptional activity of KLF11 with its role in growth regulation.
Fernandez-Zapico ME, Mladek A, Ellenrieder V, Folch-Puy E, Miller L, Urrutia R., Free PMC Article | 01/21/2010 |