| Nectin-2alpha is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula. | Nectin-2α is localized at cholinergic neuron dendrites and regulates synapse formation in the medial habenula.
Shiotani H, Miyata M, Kameyama T, Mandai K, Yamasaki M, Watanabe M, Mizutani K, Takai Y. | 12/18/2021 |
| CD112 Regulates Angiogenesis and T Cell Entry into the Spleen. | CD112 Regulates Angiogenesis and T Cell Entry into the Spleen.
Russo E, Runge P, Jahromi NH, Naboth H, Landtwing A, Montecchi R, Leicht N, Hunter MC, Takai Y, Halin C., Free PMC Article | 07/10/2021 |
| These results revealed the unique localization of nectin-2alpha and its regulatory role in the localization of Kv4.2 at the membrane specializations in the medial habenula. | Localization of nectin-2α at the boundary between the adjacent somata of the clustered cholinergic neurons and its regulatory role in the subcellular localization of the voltage-gated A-type K(+) channel Kv4.2 in the medial habenula.
Shiotani H, Miyata M, Itoh Y, Wang S, Kaito A, Mizoguchi A, Yamasaki M, Watanabe M, Mandai K, Mochizuki H, Takai Y. | 06/29/2019 |
| PVRL2 is a plasma cholesterol-responsive gene acting at endothelial sites of vascular inflammation to regulate transendothelial migration of leukocytes. | Poliovirus Receptor-Related 2: A Cholesterol-Responsive Gene Affecting Atherosclerosis Development by Modulating Leukocyte Migration.
Rossignoli A, Shang MM, Gladh H, Moessinger C, Foroughi Asl H, Talukdar HA, Franzén O, Mueller S, Björkegren JL, Folestad E, Skogsberg J. | 06/24/2017 |
| Results suggest that modulation of the expression of receptors and CD112 compensates for CD155 deficiency in immune surveillance against methylcholanthrene-induced tumors. | Increased CD112 expression in methylcholanthrene-induced tumors in CD155-deficient mice.
Nagumo Y, Iguchi-Manaka A, Yamashita-Kanemaru Y, Abe F, Bernhardt G, Shibuya A, Shibuya K., Free PMC Article | 12/19/2015 |
| We showed that cadherin and nectin in the junctions of A431 cells and human keratinocytes are located in separate clusters. | The adherens junction: a mosaic of cadherin and nectin clusters bundled by actin filaments.
Indra I, Hong S, Troyanovsky R, Kormos B, Troyanovsky S., Free PMC Article | 12/28/2013 |
| Nectin-2 is required to maintain structure and function of the intercalated disc and protects the heart from pressure-overload-induced cardiac dysfunction. | Deficiency of nectin-2 leads to cardiac fibrosis and dysfunction under chronic pressure overload.
Satomi-Kobayashi S, Ueyama T, Mueller S, Toh R, Masano T, Sakoda T, Rikitake Y, Miyoshi J, Matsubara H, Oh H, Kawashima S, Hirata K, Takai Y. | 01/21/2010 |
| expressed in early epithelial structures of the nephron generated from metanephric mesenchyme | Nectin proteins are expressed at early stages of nephrogenesis and play a role in renal epithelial cell morphogenesis.
Brakeman PR, Liu KD, Shimizu K, Takai Y, Mostov KE., Free PMC Article | 01/21/2010 |
| Inactivated nectin-2 and nectin-3 disrupted the nectin-afadin-actin system, and finally the actin filaments disappeared. As a result, the specialization lost the holding function and detachment of spermatids was observed. | Disruption of ectoplasmic specializations between Sertoli cells and maturing spermatids by anti-nectin-2 and anti-nectin-3 antibodies.
Toyama Y, Suzuki-Toyota F, Maekawa M, Ito C, Toshimori K. | 01/21/2010 |
| nectins and afadin are involved in dynamic epithelial remodeling during mouse development | Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo.
Okabe N, Ozaki-Kuroda K, Nakanishi H, Shimizu K, Takai Y. | 01/21/2010 |
| nectin-afadin system plays essential roles in coupling cell-cell adhesion and the cortical actin scaffold in spermatids at Sertoli-spermatid junctions and in subsequent sperm morphogenesis | Nectin couples cell-cell adhesion and the actin scaffold at heterotypic testicular junctions.
Ozaki-Kuroda K, Nakanishi H, Ohta H, Tanaka H, Kurihara H, Mueller S, Irie K, Ikeda W, Sakai T, Wimmer E, Nishimune Y, Takai Y. | 01/21/2010 |
| Nectin-2 expression in Sertoli cells is believed via cross-talking between CREB, c-Jun, and Sp1 family protein. | Nectin-2 expression in testicular cells is controlled via the functional cooperation between transcription factors of the Sp1, CREB, and AP-1 families.
Lui WY, Sze KL, Lee WM. | 01/21/2010 |
| Our functional analyses indicate that the infertility phenotype of nectin-2-deficient male mice is caused by a combination of reduced migration to the oviduct, spermatozoa-zona binding, and sperm-oocyte fusion | Loss of nectin-2 at Sertoli-spermatid junctions leads to male infertility and correlates with severe spermatozoan head and midpiece malformation, impaired binding to the zona pellucida, and oocyte penetration.
Mueller S, Rosenquist TA, Takai Y, Bronson RA, Wimmer E. | 01/21/2010 |