| Clustering of phosphatase RPTPalpha promotes Src signaling and the arthritogenic action of synovial fibroblasts. | Clustering of phosphatase RPTPα promotes Src signaling and the arthritogenic action of synovial fibroblasts.
Sendo S, Kiosses WB, Yang S, Wu DJ, Lee DWK, Liu L, Aschner Y, Vela AJ, Downey GP, Santelli E, Bottini N., Free PMC Article | 07/7/2023 |
| PTPalpha promotes fibroproliferative responses after acute lung injury. | PTPα promotes fibroproliferative responses after acute lung injury.
Aschner Y, Correll KA, Beke KM, Foster DG, Roybal HM, Nelson MR, Meador CL, Strand M, Anderson KC, Moore CM, Reynolds PR, Kopf KW, Burnham EL, Downey GP., Free PMC Article | 07/16/2022 |
| Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder. | Roles of Collagen XXV and Its Putative Receptors PTPσ/δ in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder.
Munezane H, Oizumi H, Wakabayashi T, Nishio S, Hirasawa T, Sato T, Harada A, Yoshida T, Eguchi T, Yamanashi Y, Hashimoto T, Iwatsubo T. | 09/26/2020 |
| In a model of spinal cord injury, blocking PTPalpha and LAR receptors promotes oligodendrogenesis. | LAR and PTPσ receptors are negative regulators of oligodendrogenesis and oligodendrocyte integrity in spinal cord injury.
Dyck S, Kataria H, Akbari-Kelachayeh K, Silver J, Karimi-Abdolrezaee S. | 05/18/2019 |
| PTPalpha coordinates oligodendroglial and neuronal development and myelination. | Glial and Neuronal Protein Tyrosine Phosphatase Alpha (PTPα) Regulate Oligodendrocyte Differentiation and Myelination.
Shih Y, Ly PTT, Wang J, Pallen CJ. | 04/28/2018 |
| RPTPalpha mediates proinflammatory and proinvasive signaling in rheumatoid arthritis fibroblast-like synoviocytes (FLS), correlating with the promotion of disease in an FLS-dependent model of rheumatoid arthritis. | Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.
Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N., Free PMC Article | 06/28/2016 |
| Ptpra coordinates the regulation of the Fyn signaling pathway in corpus striatum. | Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway.
Xu J, Kurup P, Foscue E, Lombroso PJ., Free PMC Article | 10/24/2015 |
| PTPs alpha and epsilon play distinct roles in osteoclasts. | Protein tyrosine phosphatases ε and α perform nonredundant roles in osteoclasts.
Finkelshtein E, Lotinun S, Levy-Apter E, Arman E, den Hertog J, Baron R, Elson A., Free PMC Article | 01/24/2015 |
| PTP-alpha promotes profibrotic signaling pathways in fibroblasts through control of cellular responsiveness to TGF-beta. | Protein tyrosine phosphatase α mediates profibrotic signaling in lung fibroblasts through TGF-β responsiveness.
Aschner Y, Khalifah AP, Briones N, Yamashita C, Dolgonos L, Young SK, Campbell MN, Riches DW, Redente EF, Janssen WJ, Henson PM, Sap J, Vacaresse N, Kapus A, McCulloch CA, Zemans RL, Downey GP., Free PMC Article | 12/20/2014 |
| The focal adhesion targeting domain of FAK interacts with protein-tyrosine phosphatase-alpha to restrict IL1-induced Ca2+ release, ERK activation, and MMP-9 expression. | Interactions of the protein-tyrosine phosphatase-α with the focal adhesion targeting domain of focal adhesion kinase are involved in interleukin-1 signaling in fibroblasts.
Wang Q, Wang Y, Fritz D, Rajshankar D, Downey GP, McCulloch CA., Free PMC Article | 10/18/2014 |
| PTPalpha may be involved in the formation of axoglial junctions and ensheathment in small axons during myelination of the spinal cord. | Abnormal myelination in the spinal cord of PTPα-knockout mice.
Ma QH, Xiang T, Yang ZZ, Zhang X, Taylor J, Xiao ZC., Free PMC Article | 03/22/2014 |
| Findings indicate Grb2 as a new FAK activator and in coordinating PTPalpha tyrosine phosphorylation to enable downstream integrin signaling and migration. | Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase α by the Src-FAK kinase complex.
Cheng SY, Sun G, Schlaepfer DD, Pallen CJ., Free PMC Article | 03/22/2014 |
| Results suggest that inhibition of PTPalpha can have a beneficial effect on HER2-positive breast cancers, but that inhibition of additional targets is needed to block breast tumorigenesis. | Tyrosine phosphatase PTPα contributes to HER2-evoked breast tumor initiation and maintenance.
Meyer DS, Aceto N, Sausgruber N, Brinkhaus H, Müller U, Pallen CJ, Bentires-Alj M. | 03/15/2014 |
| Inflammation-induced connective tissue degradation involving fibroblasts requires functionally active PTPalpha. | Role of PTPα in the destruction of periodontal connective tissues.
Rajshankar D, Sima C, Wang Q, Goldberg SR, Kazembe M, Wang Y, Glogauer M, Downey GP, McCulloch CA., Free PMC Article | 03/8/2014 |
| study described a molecular complex of PTPalpha-BCAR3-Cas-Src; this complex forms in response to PTPalpha Tyr789 phosphorylation and mediates Cas localization to focal adhesions and Cas downstream signaling to promote cell migration | Protein tyrosine phosphatase α phosphotyrosyl-789 binds BCAR3 to position Cas for activation at integrin-mediated focal adhesions.
Sun G, Cheng SY, Chen M, Lim CJ, Pallen CJ., Free PMC Article | 11/24/2012 |
| Protein-tyrosine phosphatase alpha acts in oligodendrocyte progenitor cells to limit self-renewal and facilitate differentiation. | Loss of protein-tyrosine phosphatase α (PTPα) increases proliferation and delays maturation of oligodendrocyte progenitor cells.
Wang PS, Wang J, Zheng Y, Pallen CJ., Free PMC Article | 06/9/2012 |
| protein kinase C and protein tyrosine phosphatase alpha participate in Src activation by 1alpha,25OH2 vitamin D3 in C2C12 skeletal muscle cells | PKC and PTPα participate in Src activation by 1α,25OH2 vitamin D3 in C2C12 skeletal muscle cells.
Buitrago C, Costabel M, Boland R. | 10/1/2011 |
| the PTPalpha-mediated increase of NB-3 level at the cell surface represents a novel function of PTPalpha in NB-3 signaling in neural development | Receptor-like protein-tyrosine phosphatase α enhances cell surface expression of neural adhesion molecule NB-3.
Ye H, Zhao T, Tan YL, Liu J, Pallen CJ, Xiao ZC., Free PMC Article | 09/17/2011 |
| these findings indicate that PTPalpha acts as an Ag-stimulated Lyn-Fyn phosphatase and a critical positive regulator of these Src family kinases in FcepsilonRI signaling | PTPalpha activates Lyn and Fyn and suppresses Hck to negatively regulate FcepsilonRI-dependent mast cell activation and allergic responses.
Samayawardhena LA, Pallen CJ. | 12/4/2010 |
| The results suggest that transformation by PTPalpha involves at least one function other than, or in addition to, its activation of Src and that this depends on PTPalpha's extracellular domain. | Extracellular domain dependence of PTPalpha transforming activity.
Tremper-Wells B, Resnick RJ, Zheng X, Holsinger LJ, Shalloway D., Free PMC Article | 11/27/2010 |
| Expression of CD45RA and -RC isoforms is increased 20- to 200-fold on T cells from mice with a loss-of-function mutation in RNA-binding protein heterogeneous nuclear ribonucleoprotein L-like, although total CD45 expression is unaltered. | Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.
Wu Z, Yates AL, Hoyne GF, Goodnow CC. | 09/6/2010 |
| Results describe the role of nitric oxide in regulating the focal adhesion proteins, Src, FAK, p130 Cas, and PTP-alpha. | Regulatory effects of nitric oxide on Src kinase, FAK, p130Cas, and receptor protein tyrosine phosphatase alpha (PTP-alpha): a role for the cellular redox environment.
Curcio MF, Batista WL, Linares E, Nascimento FD, Moraes MS, Borges RE, Sap J, Stern A, Monteiro HP. | 09/6/2010 |
| IL-1-induced signaling through focal adhesions leading to MMP3 release and interactions between SHP-2 and PTPalpha are dependent on the integrity of the catalytic domains of PTPalpha. | Importance of protein-tyrosine phosphatase-alpha catalytic domains for interactions with SHP-2 and interleukin-1-induced matrix metalloproteinase-3 expression.
Wang Q, Rajshankar D, Laschinger C, Talior-Volodarsky I, Wang Y, Downey GP, McCulloch CA., Free PMC Article | 08/9/2010 |
| A new model for mitotic activation of Src in which PP2A-mediated dephosphorylation of RPTPalpha pSer204 facilitates Src binding, is proposed. | Serine dephosphorylation of receptor protein tyrosine phosphatase alpha in mitosis induces Src binding and activation.
Vacaru AM, den Hertog J., Free PMC Article | 06/28/2010 |
| Findings demonstrate that PTPalpha is a critical regulator of Fyn activation and of specific Fyn signaling events during differentiation, and is essential for promoting OPC differentiation and central nervous system myelination. | Protein-tyrosine phosphatase alpha acts as an upstream regulator of Fyn signaling to promote oligodendrocyte differentiation and myelination.
Wang PS, Wang J, Xiao ZC, Pallen CJ., Free PMC Article | 01/25/2010 |