| Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke. | Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke.
Wang X, Zhang S, Lv B, Chen H, Zhang W, Dong L, Bao L, Wang M, Wang Y, Mao W, Cui L, Pang Y, Wang F, Yan F, Zhang Z, Cui G., Free PMC Article | 04/29/2024 |
| PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury. | PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury.
Du X, Ren B, Li C, Li Q, Kan S, Wang X, Bai W, Wu C, Kassegne K, Yan H, Niu X, Yan M, Xu W, Wassmer SC, Wang J, Chen G, Wang Z., Free PMC Article | 02/21/2024 |
| PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation. | PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.
Chen H, Bai Y, Kobayashi M, Xiao S, Barajas S, Cai W, Chen S, Miao J, Nguele Meke F, Yao C, Yang Y, Strube K, Satchivi O, Sun J, Rönnstrand L, Croop JM, Boswell HS, Jia Y, Liu H, Li LS, Altman JK, Eklund EA, Sukhanova M, Ji P, Tong W, Band H, Huang DT, Platanias LC, Zhang ZY, Liu Y., Free PMC Article | 01/8/2024 |
| CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis. | CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis.
Kang X, Cao Y, Sun G, Fei D, Kang K, Meng X, Zhao M. | 12/22/2023 |
| PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805. | PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.
Bai Y, Yu G, Zhou HM, Amarasinghe O, Zhou Y, Zhu P, Li Q, Zhang L, Nguele Meke F, Miao Y, Chapman E, Tao WA, Zhang ZY., Free PMC Article | 06/7/2023 |
| PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling. | PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling.
Poulet M, Sirois J, Boyé K, Uetani N, Hardy S, Daubon T, Dubrac A, Tremblay ML, Bikfalvi A., Free PMC Article | 06/26/2021 |
| Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis. | Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.
Li Q, Bai Y, Lyle LT, Yu G, Amarasinghe O, Nguele Meke F, Carlock C, Zhang ZY., Free PMC Article | 10/24/2020 |
| PRL2 binds to GTPase Rac. | PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS.
Yin C, Wu C, Du X, Fang Y, Pu J, Wu J, Tang L, Zhao W, Weng Y, Guo X, Chen G, Wang Z., Free PMC Article | 10/5/2019 |
| a critical role for PRL2 phosphatase in mediating Notch and c-Kit signals in early T cell progenitors, is reported. | Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors.
Kobayashi M, Nabinger SC, Bai Y, Yoshimoto M, Gao R, Chen S, Yao C, Dong Y, Zhang L, Rodriguez S, Yashiro-Ohtani Y, Pear WS, Carlesso N, Yoder MC, Kapur R, Kaplan MH, Daniel Lacorazza H, Zhang ZY, Liu Y., Free PMC Article | 12/16/2017 |
| Oncogenic PRL-2 controls tumor growth by modulating intracellular magnesium levels through binding with the CNNM3 magnesium transporter. | The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.
Hardy S, Uetani N, Wong N, Kostantin E, Labbé DP, Bégin LR, Mes-Masson A, Miranda-Saavedra D, Tremblay ML. | 05/2/2015 |
| PTP4A2 plays critical roles in regulating hematopoietic stem cell self-renewal and mediating SCF/KIT signaling. | PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal.
Kobayashi M, Bai Y, Dong Y, Yu H, Chen S, Gao R, Zhang L, Yoder MC, Kapur R, Zhang ZY, Liu Y., Free PMC Article | 02/14/2015 |
| PRL2 promotes Kit-mediated PI3K/Akt signaling by reducing the level of PTEN that normally antagonizes the pathway. | Phosphatase of regenerating liver 2 (PRL2) deficiency impairs Kit signaling and spermatogenesis.
Dong Y, Zhang L, Bai Y, Zhou HM, Campbell AM, Chen H, Yong W, Zhang W, Zeng Q, Shou W, Zhang ZY., Free PMC Article | 04/12/2014 |
| Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein | Phosphatase of regenerating liver 2 (PRL2) is essential for placental development by down-regulating PTEN (Phosphatase and Tensin Homologue Deleted on Chromosome 10) and activating Akt protein.
Dong Y, Zhang L, Zhang S, Bai Y, Chen H, Sun X, Yong W, Li W, Colvin SC, Rhodes SJ, Shou W, Zhang ZY., Free PMC Article | 12/8/2012 |