| Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA2 Prostanoids/TP Axis. | Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA(2) Prostanoids/TP Axis.
Ge J, Zhou Y, Li H, Zeng R, Xie K, Leng J, Chen X, Yu G, Shi X, Xu Y, He D, Guo P, Zhou Y, Luo H, Luo W, Liu B. | 10/8/2024 |
| Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer. | Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer.
Wang B, Ge S, Wang Z, Wang W, Wang Y, Leng H, Ma X., Free PMC Article | 10/24/2023 |
| Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity. | Coordinated action of microsomal prostaglandin E synthase-1 and prostacyclin synthase on contact hypersensitivity.
Ochiai T, Sasaki Y, Kuwata H, Nakatani Y, Yokoyama C, Hara S. | 05/22/2021 |
| Prostacyclin synthase and prostaglandin E synthase-1 cooperatively exacerbate inflammatory reactions but have opposing effects on carcinogenesis. | Genetic-deletion of Cyclooxygenase-2 Downstream Prostacyclin Synthase Suppresses Inflammatory Reactions but Facilitates Carcinogenesis, unlike Deletion of Microsomal Prostaglandin E Synthase-1.
Sasaki Y, Kamiyama S, Kamiyama A, Matsumoto K, Akatsu M, Nakatani Y, Kuwata H, Ishikawa Y, Ishii T, Yokoyama C, Hara S., Free PMC Article | 09/24/2016 |
| Taken together, our in vitro and in vivo findings show that prostacyclin is secreted from neovessels formed as a result of CNS inflammation | Angiogenesis induced by CNS inflammation promotes neuronal remodeling through vessel-derived prostacyclin.
Muramatsu R, Takahashi C, Miyake S, Fujimura H, Mochizuki H, Yamashita T. | 04/6/2013 |
| Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner. | Cyclooxygenase-2-derived prostacyclin regulates arterial thrombus formation by suppressing tissue factor in a sirtuin-1-dependent-manner.
Barbieri SS, Amadio P, Gianellini S, Tarantino E, Zacchi E, Veglia F, Howe LR, Weksler BB, Mussoni L, Tremoli E. | 01/5/2013 |
| COX-1 contributes to the enhanced formation of both PGI(2) and TXA(2) in atherosclerosis, and to the development of the disease | Contribution of cyclooxygenase-1 to thromboxane formation, platelet-vessel wall interactions and atherosclerosis in the ApoE null mouse.
McClelland S, Gawaz M, Kennerknecht E, Konrad CS, Sauer S, Schuerzinger K, Massberg S, Fitzgerald DJ, Belton O. | 01/21/2010 |
| The results establish a role for the IP receptor in protecting pyramidal hippocampal neurons after this global ischemic model and suggest that IP receptor agonists could be developed to prevent delayed pyramidal neuronal cell death. | Prostacyclin receptor deletion aggravates hippocampal neuronal loss after bilateral common carotid artery occlusion in mouse.
Wei G, Kibler KK, Koehler RC, Maruyama T, Narumiya S, Doré S., Free PMC Article | 01/21/2010 |
| PGIS/ IP transgenic animals with lung-specific PPARgamma overexpression also developed fewer lung tumors. | Prostacyclin prevents murine lung cancer independent of the membrane receptor by activation of peroxisomal proliferator--activated receptor gamma.
Nemenoff R, Meyer AM, Hudish TM, Mozer AB, Snee A, Narumiya S, Stearman RS, Winn RA, Weiser-Evans M, Geraci MW, Keith RL., Free PMC Article | 01/21/2010 |
| identify PGI(2)-prostaglandin I2 receptor as an important pathway for inhibiting allergic pulmonary inflammation by controlling recruitment of CD4(+) Th2 cells into the inflammatory site | Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma.
Jaffar Z, Ferrini ME, Buford MC, Fitzgerald GA, Roberts K. | 01/21/2010 |
| Endothelial PGI synthase-mediated prostacyclin contributes to renal protection against endotoxemia-related acute kidney injury. | Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice.
Wang W, Zolty E, Falk S, Summer S, Stearman R, Geraci M, Schrier R. | 01/21/2010 |
| Alpha(2)-adrenoreceptor activation is required for coupling heart rate to central inspiratory drive during acute hypoxia, and PGI(2) is required to enhance the inhibition of sympathoactivation. | Alpha2-adrenoreceptor mediated sympathoinhibition of heart rate during acute hypoxia is diminished in conscious prostacyclin synthase deficient mice.
Pearson JT, Shirai M, Yokoyama C, Tsuchimochi H, Schwenke DO, Shimouchi A, Kangawa K, Tanabe T. | 01/21/2010 |
| Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth. | Gene transfer of thromboxane A(2) synthase and prostaglandin I(2) synthase antithetically altered tumor angiogenesis and tumor growth.
Pradono P, Tazawa R, Maemondo M, Tanaka M, Usui K, Saijo Y, Hagiwara K, Nukiwa T. | 01/21/2010 |
| an anlysis of the transcription regulation of this gene | Analysis of the transcriptional regulation of mouse prostacyclin synthase gene.
Ohkawara S, Yokoyama C, Shimonishi M, Tanabe T. | 01/21/2010 |
| The two major genetic loci Pgis1 and Pgis2 of murine spondylitis are homologous to chromosome regions in human genome, which control ankylosing spondylitis in human patients. | Two major interacting chromosome loci control disease susceptibility in murine model of spondyloarthropathy.
Végvári A, Szabó Z, Szántó S, Nesterovitch AB, Mikecz K, Glant TT, Adarichev VA. | 01/21/2010 |
| CD40 ligand might contribute to the initiation and progression of atherosclerosis by increasing activity of prostacyclin synthase. | CD40 ligand-dependent tyrosine nitration of prostacyclin synthase in vivo.
Davis B, Zou MH. | 01/21/2010 |
| Sepiapterin not only reversed the effects of high glucose on both angiotensin II-induced relaxation and PGI(2) release but also abolished high-glucose-enhanced PGIS nitration. | Endothelial nitric oxide synthase-dependent tyrosine nitration of prostacyclin synthase in diabetes in vivo.
Nie H, Wu JL, Zhang M, Xu J, Zou MH. | 01/21/2010 |
| The results provide strong evidence that the protective effects of COX-2 within the liver are mediated through the production of PGE(2) and PGI(2), which exert anti-inflammatory functions. | Prostaglandin I(2) and E(2) mediate the protective effects of cyclooxygenase-2 in a mouse model of immune-mediated liver injury.
Yin H, Cheng L, Langenbach R, Ju C. | 01/21/2010 |