| Endogenous PGD2 acting on DP2 receptor counter regulates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis. | Endogenous PGD2 acting on DP2 receptor counter regulates Schistosoma mansoni infection-driven hepatic granulomatous fibrosis.
Pezzella-Ferreira GN, Pão CRR, Bellas I, Luna-Gomes T, Muniz VS, Paiva LA, Amorim NRT, Canetti C, Bozza PT, Diaz BL, Bandeira-Melo C., Free PMC Article | 10/31/2024 |
| Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase. | Substrate-induced product-release mechanism of lipocalin-type prostaglandin D synthase.
Shimamoto S, Nakagawa Y, Hidaka Y, Maruno T, Kobayashi Y, Kawahara K, Yoshida T, Ohkubo T, Aritake K, Kaushik MK, Urade Y. | 11/27/2021 |
| Lipocalin-type prostaglandin D2 synthase deletion induces dyslipidemia and non-alcoholic fatty liver disease. | Lipocalin-type prostaglandin D(2) synthase deletion induces dyslipidemia and non-alcoholic fatty liver disease.
Kumar S, Srivastava A, Palaia T, Hall C, Lee J, Stevenson M, Zhao CL, Ragolia L. | 06/19/2021 |
| L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis. | L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis.
Ouhaddi Y, Najar M, Paré F, Lussier B, Urade Y, Benderdour M, Pelletier JP, Martel-Pelletier J, Fahmi H., Free PMC Article | 05/29/2021 |
| Role of Lipocalin-Type Prostaglandin D Synthase in Experimental Osteoarthritis. | Role of Lipocalin-Type Prostaglandin D Synthase in Experimental Osteoarthritis.
Najar M, Ouhaddi Y, Paré F, Lussier B, Urade Y, Kapoor M, Pelletier JP, Martel-Pelletier J, Benderdour M, Fahmi H. | 01/16/2021 |
| L-PGDS-produced PGD2 in premature, but not in mature, adipocytes increases obesity and insulin resistance. | L-PGDS-produced PGD(2) in premature, but not in mature, adipocytes increases obesity and insulin resistance.
Fujimori K, Aritake K, Oishi Y, Nagata N, Maehara T, Lazarus M, Urade Y., Free PMC Article | 08/13/2020 |
| PGDS2 expression is modulated after sciatic nerve injury and regulates macrophage phagocytic activity. | Prostaglandin D2 synthase modulates macrophage activity and accumulation in injured peripheral nerves.
Forese MG, Pellegatta M, Canevazzi P, Gullotta GS, Podini P, Rivellini C, Previtali SC, Bacigaluppi M, Quattrini A, Taveggia C. | 06/6/2020 |
| interacts with voltage-gated CaV2.2 calcium channels | Four novel interaction partners demonstrate diverse modulatory effects on voltage-gated Ca(V)2.2 Ca(2+) channels.
Mallmann R, Ondacova K, Moravcikova L, Jurkovicova-Tarabova B, Pavlovicova M, Moravcik R, Lichvarova L, Kominkova V, Klugbauer N, Lacinova L. | 05/9/2020 |
| These observations suggest that tumor cell-derived inflammatory cytokines increase L-PGDS expression and subsequent PGD2 production in the tumor endothelial cells (ECs). This PGD2 acts as a negative regulator of the tumorigenic changes in tumor ECs. | Lipocalin-type prostaglandin D synthase-derived PGD(2) attenuates malignant properties of tumor endothelial cells.
Omori K, Morikawa T, Kunita A, Nakamura T, Aritake K, Urade Y, Fukayama M, Murata T. | 01/13/2018 |
| Exposure of macrophages to cyclooxygenase (COX-2) inhibitors RhoA and LA-4 cells to antagonists of prostaglandin E2 (PGE2) receptor , PGD2 receptors or the hepatocyte growth factor (HGF) receptor c-Met (PHA-665752), reversed EMT inhibition by the conditioned medium | Macrophages programmed by apoptotic cells inhibit epithelial-mesenchymal transition in lung alveolar epithelial cells via PGE2, PGD2, and HGF.
Yoon YS, Lee YJ, Choi YH, Park YM, Kang JL., Free PMC Article | 12/17/2016 |
| Ptgds is targeted and repressed by the CUL4B/PRC2 complex. | Lack of CUL4B leads to increased abundance of GFAP-positive cells that is mediated by PTGDS in mouse brain.
Zhao W, Jiang B, Hu H, Zhang S, Lv S, Yuan J, Qian Y, Zou Y, Li X, Jiang H, Liu F, Shao C, Gong Y. | 04/9/2016 |
| Thermodynamic and nuclear magnetic resonance analyses demonstrated that L-PGDS binds to nicotinamide coenzymes, including NADPH, NADP(+), and NADH. | Thermodynamic and NMR analyses of NADPH binding to lipocalin-type prostaglandin D synthase.
Qin S, Shimamoto S, Maruno T, Kobayashi Y, Kawahara K, Yoshida T, Ohkubo T. | 03/12/2016 |
| Prostaglandin D2 synthase is a novel MR target gene in adipocytes. | Adipocyte Mineralocorticoid Receptor Activation Leads to Metabolic Syndrome and Induction of Prostaglandin D2 Synthase.
Urbanet R, Nguyen Dinh Cat A, Feraco A, Venteclef N, El Mogrhabi S, Sierra-Ramos C, Alvarez de la Rosa D, Adler GK, Quilliot D, Rossignol P, Fallo F, Touyz RM, Jaisser F. | 08/29/2015 |
| When prostaglandin D2 synthase is upregulated it participates in the regulation of peripheral nervous system myelination. | Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination.
Trimarco A, Forese MG, Alfieri V, Lucente A, Brambilla P, Dina G, Pieragostino D, Sacchetta P, Urade Y, Boizet-Bonhoure B, Martinelli Boneschi F, Quattrini A, Taveggia C. | 02/7/2015 |
| expression of L-PGDS in mouse lungs decreased neutrophilic infiltration, ameliorating lung inflammation in mice. | Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2.
Kim KH, Sadikot RT, Xiao L, Christman JW, Freeman ML, Chan JY, Oh YK, Blackwell TS, Joo M., Free PMC Article | 09/6/2014 |
| Silencing of PTGDS also alleviated H-rev107-mediated suppression of cell migration and invasion | H-rev107 regulates prostaglandin D2 synthase-mediated suppression of cellular invasion in testicular cancer cells.
Shyu RY, Wu CC, Wang CH, Tsai TC, Wang LK, Chen ML, Jiang SY, Tsai FM., Free PMC Article | 02/15/2014 |
| In this report, we show for the first time that alteration of the PTGDS-governed PGD2 pathway disturbs testicular migration in mice. | Unilateral cryptorchidism in mice mutant for Ptgds.
Philibert P, Boizet-Bonhoure B, Bashamboo A, Paris F, Aritake K, Urade Y, Leger J, Sultan C, Poulat F. | 07/27/2013 |
| Data indicate a PLA2G3-lipocalin-type PGD2 synthase (L-PGDS)-PGD2 receptor DP1 loop that drives mast cell maturation. | Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis.
Taketomi Y, Ueno N, Kojima T, Sato H, Murase R, Yamamoto K, Tanaka S, Sakanaka M, Nakamura M, Nishito Y, Kawana M, Kambe N, Ikeda K, Taguchi R, Nakamizo S, Kabashima K, Gelb MH, Arita M, Yokomizo T, Nakamura M, Watanabe K, Hirai H, Nakamura M, Okayama Y, Ra C, Aritake K, Urade Y, Morimoto K, Sugimoto Y, Shimizu T, Narumiya S, Hara S, Murakami M., Free PMC Article | 07/27/2013 |
| The levels of lipocalin-type prostaglandin D2 synthase, and its product PGD2 each varied significantly among background strains of mice after wounding, and the highest Ptgds and PGD2 levels were associated with the lowest amount of regeneration. | Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44.
Nelson AM, Loy DE, Lawson JA, Katseff AS, Fitzgerald GA, Garza LA., Free PMC Article | 05/11/2013 |
| L-PGDS and PPARgamma2 coordinate to regulate carbohydrate and lipid metabolism. | Lipocalin prostaglandin D synthase and PPARγ2 coordinate to regulate carbohydrate and lipid metabolism in vivo.
Virtue S, Masoodi M, Velagapudi V, Tan CY, Dale M, Suorti T, Slawik M, Blount M, Burling K, Campbell M, Eguchi N, Medina-Gomez G, Sethi JK, Orešič M, Urade Y, Griffin JL, Vidal-Puig A., Free PMC Article | 03/23/2013 |
| The lipocalin-type prostaglandin D2 KO mice show early elevations in HPA activity with no age-related changes relative to the C57BL/6 mice. | The lipocalin-type prostaglandin D2 synthase knockout mouse model of insulin resistance and obesity demonstrates early hypothalamic-pituitary-adrenal axis hyperactivity.
Evans JF, Islam S, Urade Y, Eguchi N, Ragolia L. | 03/16/2013 |
| Results suggest that L-PGDS plays an important role in the regulation of glucose utilization in vivo. | A new role for lipocalin prostaglandin d synthase in the regulation of brown adipose tissue substrate utilization.
Virtue S, Feldmann H, Christian M, Tan CY, Masoodi M, Dale M, Lelliott C, Burling K, Campbell M, Eguchi N, Voshol P, Sethi JK, Parker M, Urade Y, Griffin JL, Cannon B, Vidal-Puig A., Free PMC Article | 01/26/2013 |
| Delta(12)-PGJ(2) is a dominant metabolite of L-PGDS-produced PGD(2) during adipogenesis and acts as an activator for adipogenesis through both PPARgamma-dependent and -independent mechanisms | Activation of adipogenesis by lipocalin-type prostaglandin D synthase-generated Δ¹²-PGJ₂ acting through PPARγ-dependent and independent pathways.
Fujimori K, Maruyama T, Kamauchi S, Urade Y. | 09/29/2012 |
| Findings demonstrate that the backbone conformation of the bottom region of mouse lipocalin-type prostaglandin D synthase is still maintained in the intermediate state. | NMR and CD analysis of an intermediate state in the thermal unfolding process of mouse lipocalin-type prostaglandin D synthase.
Miyamoto Y, Noda Y, Iida T, Yamaguchi K, Nishimura S, Tanaka A, Segawa S, Inui T. | 06/30/2012 |
| L-PGDS protein regulates glial cell migration and morphology through Marcks in prostaglandin D2 independent manner. | Lipocalin-type prostaglandin D2 synthase protein regulates glial cell migration and morphology through myristoylated alanine-rich C-kinase substrate: prostaglandin D2-independent effects.
Lee S, Jang E, Kim JH, Kim JH, Lee WH, Suk K., Free PMC Article | 06/16/2012 |