| Pgam5 aggravates hyperglycemia-induced myocardial dysfunction through disrupting Phb2-dependent mitochondrial dynamics. | Pgam5 aggravates hyperglycemia-induced myocardial dysfunction through disrupting Phb2-dependent mitochondrial dynamics.
Chen Y, Huang J, Zhou H, Lin J, Tao J., Free PMC Article | 08/27/2024 |
| ZBP1 promotes hepatocyte pyroptosis in acute liver injury by regulating the PGAM5/ROS pathway. | ZBP1 promotes hepatocyte pyroptosis in acute liver injury by regulating the PGAM5/ROS pathway.
Yan S, Yu L, Chen Z, Xie D, Huang Z, Ouyang S. | 07/22/2024 |
| Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis. | Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis.
Liu Y, Hao R, Lv J, Yuan J, Wang X, Xu C, Ma D, Duan Z, Zhang B, Dai L, Cheng Y, Lu W, Zhang X., Free PMC Article | 03/6/2024 |
| The Effect of PGAM5 on Regulating Mitochondrial Dysfunction in Ischemic Stroke. | The Effect of PGAM5 on Regulating Mitochondrial Dysfunction in Ischemic Stroke.
Ma C, Gao Q, Zhang L, Li C, Wu G, Yang L. | 12/18/2023 |
| PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation. | PGAM5 deacetylation mediated by SIRT2 facilitates lipid metabolism and liver cancer proliferation.
Fu G, Li ST, Jiang Z, Mao Q, Xiong N, Li X, Hao Y, Zhang H., Free PMC Article | 09/20/2023 |
| PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2. | PGAM5 expression levels in heart failure and protection ROS-induced oxidative stress and ferroptosis by Keap1/Nrf2.
Li S, Wen P, Zhang D, Li D, Gao Q, Liu H, Di Y. | 02/16/2023 |
| Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state. | Cleavage of mitochondrial homeostasis regulator PGAM5 by the intramembrane protease PARL is governed by transmembrane helix dynamics and oligomeric state.
Siebert V, Silber M, Heuten E, Muhle-Goll C, Lemberg MK., Free PMC Article | 10/15/2022 |
| PGAM5 interacts with Bcl-rambo and regulates apoptosis and mitophagy. | PGAM5 interacts with Bcl-rambo and regulates apoptosis and mitophagy.
Hashino T, Matsubara H, Xu J, Tanaka R, Kusagawa E, Ueda Y, Yoshida H, Kataoka T. | 10/8/2022 |
| The expression of IFN-beta is suppressed by the viral 3D polymerase via its impact on PGAM5 expression during enterovirus D68 infection. | The expression of IFN-β is suppressed by the viral 3D polymerase via its impact on PGAM5 expression during enterovirus D68 infection.
Yang Z, Zheng H, Li H, Chen Y, Hou D, Fan Q, Song J, Guo L, Liu L. | 04/30/2022 |
| Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging. | Phosphoglycerate mutase family member 5 maintains oocyte quality via mitochondrial dynamic rearrangement during aging.
Li CJ, Lin LT, Tsai HW, Wen ZH, Tsui KH., Free PMC Article | 04/23/2022 |
| DHEA restores mitochondrial dynamics of cumulus cells by regulating PGAM5 expression in poor ovarian responders. | DHEA restores mitochondrial dynamics of cumulus cells by regulating PGAM5 expression in poor ovarian responders.
Hou YL, Li CJ, Lin LT, Chen SN, Wen ZH, Tsui KH. | 04/9/2022 |
| Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteins during mitophagy. | Cleaved PGAM5 dephosphorylates nuclear serine/arginine-rich proteins during mitophagy.
Baba T, Tanimura S, Yamaguchi A, Horikawa K, Yokozeki M, Hachiya S, Iemura SI, Natsume T, Matsuda N, Takeda K. | 10/2/2021 |
| PGAM5: A crucial role in mitochondrial dynamics and programmed cell death. | PGAM5: A crucial role in mitochondrial dynamics and programmed cell death.
Cheng M, Lin N, Dong D, Ma J, Su J, Sun L. | 08/28/2021 |
| Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate. | Dynamic PGAM5 multimers dephosphorylate BCL-xL or FUNDC1 to regulate mitochondrial and cellular fate.
Ma K, Zhang Z, Chang R, Cheng H, Mu C, Zhao T, Chen L, Zhang C, Luo Q, Lin J, Zhu Y, Chen Q., Free PMC Article | 07/3/2021 |
| Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway. | Empagliflozin improves diabetic renal tubular injury by alleviating mitochondrial fission via AMPK/SP1/PGAM5 pathway.
Liu X, Xu C, Xu L, Li X, Sun H, Xue M, Li T, Yu X, Sun B, Chen L. | 11/21/2020 |
| Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics. | Mitochondrial phosphatase PGAM5 modulates cellular senescence by regulating mitochondrial dynamics.
Yu B, Ma J, Li J, Wang D, Wang Z, Wang S., Free PMC Article | 08/22/2020 |
| Elevated PGAM5 expression in hepatocellular carcinoma is associated with a poor prognostic phenotype. Knocking down PGAM5 in hepatocellular carcinoma cells inhibited cell viability and enhanced chemosensitivity. | High PGAM5 expression induces chemoresistance by enhancing Bcl-xL-mediated anti-apoptotic signaling and predicts poor prognosis in hepatocellular carcinoma patients.
Cheng J, Qian D, Ding X, Song T, Cai M, Dan Xie, Wang Y, Zhao J, Liu Z, Wu Z, Pang Q, Zhu L, Wang P, Hao X, Yuan Z., Free PMC Article | 12/14/2019 |
| PGAM5-mediated mitophagy in turn leads to a self-perpetuating escalation of DeltaPsi depolarization. Loss of the mitophagy-based damage-enhancing loop under PGAM5-deficient conditions breaks this vicious cycle, leading to improved mitochondrial homeostasis. | PGAM5 is a key driver of mitochondrial dysfunction in experimental lung fibrosis.
Ganzleben I, He GW, Günther C, Prigge ES, Richter K, Rieker RJ, Mougiakakos D, Neurath MF, Becker C., Free PMC Article | 11/30/2019 |
| have identified phosphoglycerate mutase family member 5 (PGAM5), a serine/threonine specific protein phosphatase, as a regulator of Lipin-1 activity. Activation of endogenous PGAM5, promoted dephosphorylation and nuclear accumulation of Lipin-1 | Lipin-1 is a novel substrate of protein phosphatase PGAM5.
Okuno H, Okuzono H, Hayase A, Kumagai F, Tanii S, Hino N, Okada Y, Tachibana K, Doi T, Ishimoto K. | 11/9/2019 |
| results reveal that the Stx17-PGAM5 axis plays pivotal roles in mitochondrial division and PINK1/Parkin-mediated mitophagy. | Syntaxin 17 regulates the localization and function of PGAM5 in mitochondrial division and mitophagy.
Sugo M, Kimura H, Arasaki K, Amemiya T, Hirota N, Dohmae N, Imai Y, Inoshita T, Shiba-Fukushima K, Hattori N, Cheng J, Fujimoto T, Wakana Y, Inoue H, Tagaya M., Free PMC Article | 10/5/2019 |
| PGAM5 is expressed in pre-neoplastic tissue and non-small cell lung carcinoma, but not in normal epithelium. | PGAM5 expression and macrophage signatures in non-small cell lung cancer associated with chronic obstructive pulmonary disease (COPD).
Ng Kee Kwong F, Nicholson AG, Pavlidis S, Adcock IM, Chung KF., Free PMC Article | 04/6/2019 |
| Damaged mitochondria may induce replenishment of the mitochondrial pool by cell-intrinsic activation of Wnt signaling via the Pgam5-beta-catenin axis. | Pgam5 released from damaged mitochondria induces mitochondrial biogenesis via Wnt signaling.
Bernkopf DB, Jalal K, Brückner M, Knaup KX, Gentzel M, Schambony A, Behrens J., Free PMC Article | 03/23/2019 |
| suggests that PGAM5 senses mitochondrial dysfunction in the inner mitochondrial membrane and serves as a signalling intermediate that regulates the cellular response to mitochondrial stress upon its cleavage and release from mitochondria | Cleaved PGAM5 is released from mitochondria depending on proteasome-mediated rupture of the outer mitochondrial membrane during mitophagy.
Yamaguchi A, Ishikawa H, Furuoka M, Yokozeki M, Matsuda N, Tanimura S, Takeda K. | 01/26/2019 |
| An intact complex of PGAM5-KEAP1-Nrf2 preserves mitochondrial motility by suppressing dominant-negative KEAP1 activity. | A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking.
O'Mealey GB, Plafker KS, Berry WL, Janknecht R, Chan JY, Plafker SM., Free PMC Article | 06/9/2018 |
| PGAM5 regulates histidine phosphorylation to control TCR activation of CD4-positive T cells. | Identification of PGAM5 as a Mammalian Protein Histidine Phosphatase that Plays a Central Role to Negatively Regulate CD4(+) T Cells.
Panda S, Srivastava S, Li Z, Vaeth M, Fuhs SR, Hunter T, Skolnik EY., Free PMC Article | 09/2/2017 |