| Prominin 1 is crucial for the early development of photoreceptor outer segments. | Prominin 1 is crucial for the early development of photoreceptor outer segments.
Yanardag S, Rhodes S, Saravanan T, Guan T, Ramamurthy V., Free PMC Article | 05/28/2024 |
| Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity. | Impact of heterogeneous nuclear ribonucleoprotein A/B subtype overexpression on the expression of cancer stem cell markers CD133 and CD44 and cellular proliferation capacity.
Wang M, Wang X, Cui Y, Wen X. | 02/1/2024 |
| PROM1-mediated cell signal transduction in cancer stem cells and hepatocytes. | PROM1-mediated cell signal transduction in cancer stem cells and hepatocytes.
Bahn MS, Ko YG., Free PMC Article | 03/15/2023 |
| Prominin-1 promotes restitution of the murine extrahepatic biliary luminal epithelium following cholestatic liver injury. | Prominin-1 promotes restitution of the murine extrahepatic biliary luminal epithelium following cholestatic liver injury.
Zhong A, Short C, Xu J, Fernandez GE, Malkoff N, Noriega N, Yeo T, Wang L, Mavila N, Asahina K, Wang KS., Free PMC Article | 02/4/2023 |
| Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7. | Hepatocyte-specific Prominin-1 protects against liver injury-induced fibrosis by stabilizing SMAD7.
Lee H, Yu DM, Bahn MS, Kwon YJ, Um MJ, Yoon SY, Kim KT, Lee MW, Jo SJ, Lee S, Koo SH, Jung KH, Lee JS, Ko YG., Free PMC Article | 09/17/2022 |
| Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina. | Early manifestations and differential gene expression associated with photoreceptor degeneration in Prom1-deficient retina.
Kobayashi Y, Watanabe S, Ong ALC, Shirai M, Yamashiro C, Ogata T, Higashijima F, Yoshimoto T, Hayano T, Asai Y, Sasai N, Kimura K., Free PMC Article | 04/9/2022 |
| A Subpopulation of Microglia Generated in the Adult Mouse Brain Originates from Prominin-1-Expressing Progenitors. | A Subpopulation of Microglia Generated in the Adult Mouse Brain Originates from Prominin-1-Expressing Progenitors.
Prater KE, Aloi MS, Pathan JL, Winston CN, Chernoff RA, Davidson S, Sadgrove M, McDonough A, Zierath D, Su W, Weinstein JR, Garden GA., Free PMC Article | 11/27/2021 |
| Prominin-1-expressing hepatic progenitor cells induce fibrogenesis in murine cholestatic liver injury. | Prominin-1-expressing hepatic progenitor cells induce fibrogenesis in murine cholestatic liver injury.
Fenlon M, Short C, Xu J, Malkoff N, Mahdi E, Hough M, Glazier A, Lee C, Asahina K, Wang KS., Free PMC Article | 07/10/2021 |
| Prominin-1-Radixin axis controls hepatic gluconeogenesis by regulating PKA activity. | Prominin-1-Radixin axis controls hepatic gluconeogenesis by regulating PKA activity.
Lee H, Yu DM, Park JS, Lee H, Kim JS, Kim HL, Koo SH, Lee JS, Lee S, Ko YG., Free PMC Article | 05/1/2021 |
| The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling. | The stem cell marker Prom1 promotes axon regeneration by down-regulating cholesterol synthesis via Smad signaling.
Lee J, Shin JE, Lee B, Kim H, Jeon Y, Ahn SH, Chi SW, Cho Y., Free PMC Article | 09/12/2020 |
| Study suggests that a miR-92-driven signaling axis involving integrin activation of TGFbeta in CSCs promotes enhanced tumorigenesis through induction of intratumoral immunosuppression. | MicroRNA-92 Expression in CD133(+) Melanoma Stem Cells Regulates Immunosuppression in the Tumor Microenvironment via Integrin-Dependent Activation of TGFβ.
Shidal C, Singh NP, Nagarkatti P, Nagarkatti M., Free PMC Article | 04/11/2020 |
| The histological data revealed the progression of liver cancer. Immunohistochemical analysis showed the strong expression of CD133 in metastatic cancer. In contrast, the expression of CD13 in both primary and metastatic liver cancer was found to be very strong. | Aberrant expression of CD13 and stem cell markers in CD133-induced liver cancer in mice.
Wang Q, Chen N, Yu C, Wei Z, Li Z, Jin Z. | 03/7/2020 |
| These results suggest that VEGF enters lung tissues from the circulation and that it attenuates lung injury not by directly inhibiting release of pro-inflammatory factors but by binding to VEGFR1 to recruit CD133+ progenitors. | VEGF attenuates lung injury by inducing homing of CD133(+) progenitors via VEGFR1.
Qiu Y, Chen C, Zhang J, Chen M, Gong H, Gong L, Du L, Wang R. | 01/25/2020 |
| Study proposes that Prom1 is a key regulator ensuring appropriate response of stem cells to extracellular signals, with important implications for development, regeneration, and diseases. | Prominin-1 controls stem cell activation by orchestrating ciliary dynamics.
Singer D, Thamm K, Zhuang H, Karbanová J, Gao Y, Walker JV, Jin H, Wu X, Coveney CR, Marangoni P, Lu D, Grayson PRC, Gulsen T, Liu KJ, Ardu S, Wann AK, Luo S, Zambon AC, Jetten AM, Tredwin C, Klein OD, Attanasio M, Carmeliet P, Huttner WB, Corbeil D, Hu B., Free PMC Article | 12/28/2019 |
| CD133 itself appears to play a functional role in renal tubular repair through maintenance of proliferative response and control of senescence. | Role of CD133 Molecule in Wnt Response and Renal Repair.
Brossa A, Papadimitriou E, Collino F, Incarnato D, Oliviero S, Camussi G, Bussolati B., Free PMC Article | 09/7/2019 |
| Prominin-1 regulates microvilli architecture and dynamics. | Prominin-1 (CD133) modulates the architecture and dynamics of microvilli.
Thamm K, Šimaitė D, Karbanová J, Bermúdez V, Reichert D, Morgenstern A, Bornhäuser M, Huttner WB, Wilsch-Bräuninger M, Corbeil D. | 08/17/2019 |
| Prominin-1-expressing cells from neonatal IC generated neurospheres, and culture of these neurospheres in differentiation-conditioned medium gave rise to gamma-aminobutyric acid-ergic (GABAergic) neurons, astrocytes, and oligodendrocytes. | Cells Expressing Prominin-1 in Neonatal Murine Inferior Colliculus Differentiate into Neurons and Glia.
Okazaki H, Kanda A, Kanda S, Shimono T, Yun Y, Kobayashi Y, Wang Z, Ooka H, Suzuki K, Van DB, Tomoda K, Iwai H, Nishiyama T., Free PMC Article | 02/16/2019 |
| Hypomyelination in CD133(-/-) mice was associated with fewer oligodendrocyte progenitor cells and mature oligodendrocytes. Behavioral analyses revealed that significantly impaired object recognition memory and altered Y-maze performance by CD133(-/-) mice compared with wild-type mice, suggesting perturbed cognitive performance. | Hypomyelination and cognitive impairment in mice lacking CD133 (Prominin-1).
Choi MH, Na JE, Yoon YR, Rhyu IJ, Ko YG, Baik JH. | 11/10/2018 |
| Study evaluated the different components of the mouse subventricular zone (SVZ) during the first week after chemical induction of type 1 and type 2 diabetes-like (T1DM and T2DM) conditions. Only T2DM mice showed SVZ damage. The initial lesions were localized to ependymal cilia, which appeared disorientated and clumped together. In addition, they showed delocalization of the ciliary membrane protein prominin-1. | Early ciliary and prominin-1 dysfunctions precede neurogenesis impairment in a mouse model of type 2 diabetes.
Bachor TP, Karbanová J, Büttner E, Bermúdez V, Marquioni-Ramella M, Carmeliet P, Corbeil D, Suburo AM. | 07/28/2018 |
| CD133-CD55- common progenitors are the main source of CXCL12 and Kitl producing cells in the developing marrow. | Identification of a CD133-CD55- population functions as a fetal common skeletal progenitor.
Weng L, Hu X, Kumar B, Garcia M, Todorov I, Jung X, Marcucci G, Forman SJ, Chen CC., Free PMC Article | 06/9/2018 |
| During biliary fibrosis Prominin-1-expressing progenitor cells transdifferentiate into cells within ductular reactions. This transdifferentiation may promote fibrosis. | Hepatic Prominin-1 expression is associated with biliary fibrosis.
Nguyen MV, Zagory JA, Dietz WH, Park A, Fenlon M, Zhao M, Xu J, Lua I, Mavila N, Asahina K, Wang KS., Free PMC Article | 08/19/2017 |
| findings clearly demonstrate that Wnt ligands produced by CD133+ DP cells play an important role in postnatal hair growth by maintaining the inductivity of DP cells and mediating the signaling cross-talk between the mesenchyme and the epithelial compartment | CD133-positive dermal papilla-derived Wnt ligands regulate postnatal hair growth.
Zhou L, Yang K, Carpenter A, Lang RA, Andl T, Zhang Y., Free PMC Article | 07/1/2017 |
| Prom1 positive pulmonary vascular endothelial cells can play a role in local pulmonary vascular homeostasis and repair. | Prominin-1/CD133 expression as potential tissue-resident vascular endothelial progenitor cells in the pulmonary circulation.
Sekine A, Nishiwaki T, Nishimura R, Kawasaki T, Urushibara T, Suda R, Suzuki T, Takayanagi S, Terada J, Sakao S, Tada Y, Iwama A, Tatsumi K. | 05/20/2017 |
| High CD133 promoted stem-ness characteristics and metastasis potential in sphere-forming liver cancer stem cells. | Notch and Wnt/β-catenin signaling pathway play important roles in activating liver cancer stem cells.
Wang R, Sun Q, Wang P, Liu M, Xiong S, Luo J, Huang H, Du Q, Geller DA, Cheng B., Free PMC Article | 12/17/2016 |
| Prom1+ dermal papilla(DP) cells do not contribute to dermal repair but are nevertheless capable of regulating DP size via beta-catenin-mediated intercellular communication. | Fate of Prominin-1 Expressing Dermal Papilla Cells during Homeostasis, Wound Healing and Wnt Activation.
Kaushal GS, Rognoni E, Lichtenberger BM, Driskell RR, Kretzschmar K, Hoste E, Watt FM., Free PMC Article | 03/5/2016 |