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    Prl prolactin [ Mus musculus (house mouse) ]

    Gene ID: 19109, updated on 27-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Prolactin promotes the recruitment of main olfactory bulb cells and enhances the behavioral exploration toward a socio-sexual stimulus in female mice.

    Prolactin promotes the recruitment of main olfactory bulb cells and enhances the behavioral exploration toward a socio-sexual stimulus in female mice.
    Cerbantez-Bueno V, Viñuela-Berni V, Muñoz-Mayorga DE, Morales T, Corona R.

    07/5/2024
    Unexpected Plasma Gonadal Steroid and Prolactin Levels Across the Mouse Estrous Cycle.

    Unexpected Plasma Gonadal Steroid and Prolactin Levels Across the Mouse Estrous Cycle.
    Wall EG, Desai R, Khant Aung Z, Yeo SH, Grattan DR, Handelsman DJ, Herbison AE., Free PMC Article

    06/18/2023
    Prolactin in headache and migraine: A systematic review of preclinical studies.

    Prolactin in headache and migraine: A systematic review of preclinical studies.
    Al-Karagholi MA, Kalatharan V, Ghanizada H, Dussor G, Ashina M.

    05/17/2023
    Associations among the TREM-1 Pathway, Tau Hyperphosphorylation, Prolactin Expression, and Metformin in Diabetes Mice.

    Associations among the TREM-1 Pathway, Tau Hyperphosphorylation, Prolactin Expression, and Metformin in Diabetes Mice.
    Duc Nguyen H, Hoang NMH, Jo WH, Ham JR, Lee MK, Kim MS.

    01/7/2023
    Prolactin-Induced Protein facilitates corneal wound healing.

    Prolactin-Induced Protein facilitates corneal wound healing.
    Liang W, Ma JX, Van L, Vasini B, Karamichos D.

    12/10/2022
    Vasoinhibin is Generated and Promotes Inflammation in Mild Antigen-induced Arthritis.

    Vasoinhibin is Generated and Promotes Inflammation in Mild Antigen-induced Arthritis.
    Ortiz G, Ledesma-Colunga MG, Wu Z, García-Rodrigo JF, Adan N, Martinez-Diaz OF, De Los Ríos EA, López-Barrera F, Martínez de la Escalera G, Clapp C., Free PMC Article

    05/7/2022
    Maternal prolactin levels during late pregnancy and nurturing behavior of offspring in mice.

    Maternal prolactin levels during late pregnancy and nurturing behavior of offspring in mice.
    Masuda S, Ee OK, Sairenji TJ, Sato S, Yajima H, Amano I, Koibuchi N, Shimokawa N.

    04/2/2022
    The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro.

    The effect of circadian rhythm on prolactin/PRLR-mediated intracellular signaling profiles in vivo and in vitro.
    Yuzhen C, Zheng F.

    03/5/2022
    Prolactin enhances hippocampal synaptic plasticity in female mice of reproductive age.

    Prolactin enhances hippocampal synaptic plasticity in female mice of reproductive age.
    Zamora-Moratalla A, Martín ED., Free PMC Article

    02/26/2022
    Prolactin Increases the Frequency of Follicular T Helper Cells with Enhanced IL21 Secretion and OX40 Expression in Lupus-Prone MRL/lpr Mice.

    Prolactin Increases the Frequency of Follicular T Helper Cells with Enhanced IL21 Secretion and OX40 Expression in Lupus-Prone MRL/lpr Mice.
    Alemán-García YP, Vaquero-García RM, Flores-Fernández R, Fuentes-Pananá EM, Gorocica-Rosete P, Pizaña-Venegas A, Chávez-Sanchéz L, Blanco-Favela F, Legorreta-Haquet MV, Chávez-Rueda AK., Free PMC Article

    11/13/2021
    Prolactin synergizes with canonical Wnt signals to drive development of ER+ mammary tumors via activation of the Notch pathway.

    Prolactin synergizes with canonical Wnt signals to drive development of ER+ mammary tumors via activation of the Notch pathway.
    O'Leary KA, Rugowski DE, Shea MP, Sullivan R, Moser AR, Schuler LA., Free PMC Article

    08/7/2021
    miR-375 acts as a novel factor modulating pituitary prolactin synthesis through Rasd1 and Esr1.

    miR-375 acts as a novel factor modulating pituitary prolactin synthesis through Rasd1 and Esr1.
    Zhang J, Gao J, Zhang D, Liu H, Gou K, Cui S.

    08/7/2021
    No evidence for prolactin's involvement in the post-ejaculatory refractory period.

    No evidence for prolactin's involvement in the post-ejaculatory refractory period.
    Valente S, Marques T, Lima SQ., Free PMC Article

    07/3/2021
    MicroRNA-7a2 Regulates Prolactin in Developing Lactotrophs and Prolactinoma Cells.

    MicroRNA-7a2 Regulates Prolactin in Developing Lactotrophs and Prolactinoma Cells.
    LaPierre MP, Godbersen S, Torres Esteban M, Schad AN, Treier M, Ghoshdastider U, Stoffel M., Free PMC Article

    05/1/2021
    The Transcription Factor NR4A2 Plays an Essential Role in Driving Prolactin Expression in Female Pituitary Lactotropes.

    The Transcription Factor NR4A2 Plays an Essential Role in Driving Prolactin Expression in Female Pituitary Lactotropes.
    Peel MT, Ho Y, Liebhaber SA., Free PMC Article

    01/9/2021
    Inhibition of epidermal growth factor receptor stimulates prolactin expression in primary culture of the mouse pituitary gland.

    Inhibition of epidermal growth factor receptor stimulates prolactin expression in primary culture of the mouse pituitary gland.
    Nogami H, Koshida R, Omori H, Shibata M, Harigaya T, Takei Y.

    10/24/2020
    The above findings suggest a protective role for exercise against chronic stress-evoked defects in memory consolidation via PRL.

    Exercise Prevents Memory Consolidation Defects Via Enhancing Prolactin Responsiveness of CA1 Neurons in Mice Under Chronic Stress.
    Leem YH, Park JS, Chang H, Park J, Kim HS.

    01/18/2020
    This study suggests that local production of PRL is the main resource of PRL in skin lesions and may play an important role in skin inflammatory of psoriasis.

    Local production of prolactin in lesions may play a pathogenic role in psoriatic patients and imiquimod-induced psoriasis-like mouse model.
    Yang H, Li X, Xue F, Xia Q, Zhao X, Wang D, Chen L, Cao H, Xu H, Shen X, Yuan W, Zhao X, Shi R, Zheng J.

    08/17/2019
    Neurons directly affected by prolactin were visualized using pSTAT5 immunohistochemistry in the brains of nursing mice. Estrogen-sensitive neurons are more likely to be affected by prolactin than by direct neuronal activation

    Prolactin-induced and neuronal activation in the brain of mother mice.
    Oláh S, Cservenák M, Keller D, Fazekas EA, Renner É, Lőw P, Dobolyi A.

    12/22/2018
    Study shows that prolactin was sufficient to suppress corticotrophin-releasing hormone (CRH) mRNA expression in the paraventricular nucleus, however it does not appear to be required for the ongoing regulation of the CRH neurones in lactation.

    The role of prolactin in the suppression of Crh mRNA expression during pregnancy and lactation in the mouse.
    Gustafson P, Bunn SJ, Grattan DR.

    05/26/2018
    Mechanistically, RL negatively regulates Stat5 phosphorylation and Elf5 expression at the onset of lactogenesis. Continuous RL exposure leads to the expansion of basal and bipotent cells in WT and MMTV-RANK acini. Overall, we demonstrate that enhanced Rank signaling impairs secretory differentiation during pregnancy by inhibition of the prolactin/p-Stat5 pathway.

    Rankl Impairs Lactogenic Differentiation Through Inhibition of the Prolactin/Stat5 Pathway at Midgestation.
    Cordero A, Pellegrini P, Sanz-Moreno A, Trinidad EM, Serra-Musach J, Deshpande C, Dougall WC, Pujana MA, González-Suárez E.

    01/14/2017
    Twenty-two separate mouse genes encode the placenta Prl-related hormones

    Pregnancy Hyperglycemia in Prolactin Receptor Mutant, but Not Prolactin Mutant, Mice and Feeding-Responsive Regulation of Placental Lactogen Genes Implies Placental Control of Maternal Glucose Homeostasis.
    Rawn SM, Huang C, Hughes M, Shaykhutdinov R, Vogel HJ, Cross JC., Free PMC Article

    06/28/2016
    Prolactin transport into mouse brain is independent of prolactin receptor.

    Prolactin transport into mouse brain is independent of prolactin receptor.
    Brown RS, Wyatt AK, Herbison RE, Knowles PJ, Ladyman SR, Binart N, Banks WA, Grattan DR.

    06/28/2016
    Survivin directly participates in PRL-mediated beta cell proliferation via Akt, STAT5-PIM and ERK signalling pathways during pregnancy

    Prolactin-stimulated survivin induction is required for beta cell mass expansion during pregnancy in mice.
    Xu Y, Wang X, Gao L, Zhu J, Zhang H, Shi H, Woo M, Wu X.

    06/11/2016
    AR signalling is dispensable in the male mouse pituitary for testosterone-dependent regulation of LH secretion

    Pituitary androgen receptor signalling regulates prolactin but not gonadotrophins in the male mouse.
    O'Hara L, Curley M, Tedim Ferreira M, Cruickshanks L, Milne L, Smith LB., Free PMC Article

    02/27/2016
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