| Nitration of protein kinase G-Ialpha modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury. | Nitration of protein kinase G-Iα modulates cyclic nucleotide crosstalk via phosphodiesterase 3A: Implications for acute lung injury.
Zemskov EA, Wu X, Aggarwal S, Yegambaram M, Gross C, Lu Q, Wang H, Tang H, Wang T, Black SM., Free PMC Article | 08/28/2024 |
| Ferulic acid ameliorates lipopolysaccharide-induced tracheal injury via cGMP/PKGII signaling pathway. | Ferulic acid ameliorates lipopolysaccharide-induced tracheal injury via cGMP/PKGII signaling pathway.
Xie X, Yu T, Hou Y, Han A, Ding Y, Nie H, Cui Y., Free PMC Article | 03/19/2022 |
| Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing. | Protein kinase G1 regulates bone regeneration and rescues diabetic fracture healing.
Schall N, Garcia JJ, Kalyanaraman H, China SP, Lee JJ, Sah RL, Pfeifer A, Pilz RB., Free PMC Article | 07/10/2021 |
| The endothelial nitric oxide synthase/cyclic guanosine monophosphate/protein kinase G pathway activates primordial follicles. | The endothelial nitric oxide synthase/cyclic guanosine monophosphate/protein kinase G pathway activates primordial follicles.
Zhao P, Song Z, Wang Y, Cai H, Du X, Li C, Lv J, Liu X, Guo M, Chen Z., Free PMC Article | 05/8/2021 |
| These results suggest that cGKI in vascular smooth muscle cells should be targeted by therapies designed to protect brain tissue against ischemic stroke. | cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice.
Shvedova M, Litvak MM, Roberts JD Jr, Fukumura D, Suzuki T, Şencan İ, Li G, Reventun P, Buys ES, Kim HH, Sakadžić S, Ayata C, Huang PL, Feil R, Atochin DN., Free PMC Article | 05/9/2020 |
| Increased oxidation of PKGIalpha to its disulfide-activated state found in pulmonary arteries from mice with hypoxic pulmonary arterial hypertension (PH) or lungs from patients. It caused by chronic hypoxia, and it limits progression of PH by pulmonary vasodilation that counters and offsets maladaptive vasoconstriction, and also disulfide PKGIalpha is protective by preventing maladaptive growth and fibrosis signaling. | Oxidation of PKGIα mediates an endogenous adaptation to pulmonary hypertension.
Rudyk O, Rowan A, Prysyazhna O, Krasemann S, Hartmann K, Zhang M, Shah AM, Ruppert C, Weiss A, Schermuly RT, Ida T, Akaike T, Zhao L, Eaton P., Free PMC Article | 04/11/2020 |
| Study shows that mice carrying gain-of-function mutation in PRKG1 recapitulate the human early-onset thoracic aortic disease, and that pathological changes in the aorta are, at least in part, caused by oxidative stress, revealing that increased basal PKG activity induces oxidative stress in the aorta, raising concern about the widespread clinical use of PKG-activating drugs. | Aortic pathology from protein kinase G activation is prevented by an antioxidant vitamin B(12) analog.
Schwaerzer GK, Kalyanaraman H, Casteel DE, Dalton ND, Gu Y, Lee S, Zhuang S, Wahwah N, Schilling JM, Patel HH, Zhang Q, Makino A, Milewicz DM, Peterson KL, Boss GR, Pilz RB., Free PMC Article | 12/14/2019 |
| the NF-kappaB/miR-155-5p/PKG1 axis may be crucial in the pathogenesis of inflammatory vascular diseases, such as atherosclerotic intimal hyperplasia and preeclamptic hypertension. | TNF-α elicits phenotypic and functional alterations of vascular smooth muscle cells by miR-155-5p-dependent down-regulation of cGMP-dependent kinase 1.
Choi S, Park M, Kim J, Park W, Kim S, Lee DK, Hwang JY, Choe J, Won MH, Ryoo S, Ha KS, Kwon YG, Kim YM., Free PMC Article | 04/6/2019 |
| Prkg1 cascade role in platelet activation and thrombosis. | A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis.
Wen L, Feil S, Wolters M, Thunemann M, Regler F, Schmidt K, Friebe A, Olbrich M, Langer H, Gawaz M, de Wit C, Feil R., Free PMC Article | 01/19/2019 |
| These data thus demonstrate the existence of two differently distributed cGKI isoforms in the dorsal root ganglion, and may provide insight into the cellular and molecular mechanisms of pain. | Two isoforms of cyclic GMP-dependent kinase-I exhibit distinct expression patterns in the adult mouse dorsal root ganglion.
Uchida H, Matsumura S, Katano T, Watanabe M, Schlossmann J, Ito S., Free PMC Article | 12/22/2018 |
| This study demonstrates that H- ras deletion protects against AngII-induced cardiac remodeling, possibly via a mechanism in which PKG-Ibeta overexpression could play a partial role, and points to H-Ras and/or downstream proteins as potential therapeutic targets in cardiovascular disease. | H- ras deletion protects against angiotensin II-induced arterial hypertension and cardiac remodeling through protein kinase G-Iβ pathway activation.
Martín-Sánchez P, Luengo A, Griera M, Orea MJ, López-Olañeta M, Chiloeches A, Lara-Pezzi E, de Frutos S, Rodríguez-Puyol M, Calleros L, Rodríguez-Puyol D. | 10/27/2018 |
| that PKG-I expressed in nociceptors is not only a key determinant of dorsal root ganglion hyperexcitability and spinal synaptic plasticity but also an important modulator of cortical neuronal activity in pathological pain states | Cyclic GMP-dependent protein kinase-I localized in nociceptors modulates nociceptive cortical neuronal activity and pain hypersensitivity.
Gangadharan V, Wang X, Luo C., Free PMC Article | 09/8/2018 |
| Despite robust evidence for PKG Ialpha oxidation during NOS uncoupling in cell models, it is unlikely that PKG Ialpha oxidation occurs to a significant extent in vivo during diet-induced obesity and so is unlikely to mediate the associated cardiovascular dysfunction. | Examining a role for PKG Iα oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity.
Rudyk O, Eaton P., Free PMC Article | 04/14/2018 |
| analysis of the role of binding interface with protein kinase G-Ialpha leucine zipper in vascular function | NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function.
Sharma AK, Birrane G, Anklin C, Rigby AC, Alper SL., Free PMC Article | 07/15/2017 |
| Brown adipose tissue, via Nox4-derived hydrogen peroxide, induces cyclic GMP-dependent protein kinase G type-1alpha activation, resulting in reduced vascular contractility. | Brown Adipose Tissue Regulates Small Artery Function Through NADPH Oxidase 4-Derived Hydrogen Peroxide and Redox-Sensitive Protein Kinase G-1α.
Friederich-Persson M, Nguyen Dinh Cat A, Persson P, Montezano AC, Touyz RM. | 06/24/2017 |
| disulfide formation at Cys(43) does not directly activate PKGIalpha, and the C43S-mutant PKGIalpha has a higher Ka for cGMP. Results highlight that mutant enzymes should be carefully biochemically characterized before making in vivo inferences. | The activity of cGMP-dependent protein kinase Iα is not directly regulated by oxidation-induced disulfide formation at cysteine 43.
Kalyanaraman H, Zhuang S, Pilz RB, Casteel DE., Free PMC Article | 06/10/2017 |
| PKG Ialpha disulfide formation triggers cardiac injury, and this initiation of maladaptive signaling can be blocked by pharmacological therapies that elevate cGMP, which binds kinase to limit its oxidation. | Phosphodiesterase 5 Inhibition Limits Doxorubicin-induced Heart Failure by Attenuating Protein Kinase G Iα Oxidation.
Prysyazhna O, Burgoyne JR, Scotcher J, Grover S, Kass D, Eaton P., Free PMC Article | 05/6/2017 |
| Cyclic GMP kinase deletion causes iron deficiency anemia, duodenal ulcers, and bleeding in the knockout mice. | Iron deficiency anemia in cyclic GMP kinase knockout mice.
Angermeier E, Domes K, Lukowski R, Schlossmann J, Rathkolb B, Angelis MH, Hofmann F., Free PMC Article | 01/14/2017 |
| Protein kinase G has a role in regulating production of H2S, which governs oxygen sensing | Protein kinase G-regulated production of H2S governs oxygen sensing.
Yuan G, Vasavda C, Peng YJ, Makarenko VV, Raghuraman G, Nanduri J, Gadalla MM, Semenza GL, Kumar GK, Snyder SH, Prabhakar NR., Free PMC Article | 01/23/2016 |
| cGMP/protein kinase G signaling suppresses Itpr1 phosphorylation and promotes endoplasmic reticulum stress in photoreceptors of Cnga3-deficient mice. | cGMP/Protein Kinase G Signaling Suppresses Inositol 1,4,5-Trisphosphate Receptor Phosphorylation and Promotes Endoplasmic Reticulum Stress in Photoreceptors of Cyclic Nucleotide-gated Channel-deficient Mice.
Ma H, Butler MR, Thapa A, Belcher J, Yang F, Baehr W, Biel M, Michalakis S, Ding XQ., Free PMC Article | 11/21/2015 |
| these results demonstrate that myocardial PKG1alpha oxidation prevents a beneficial response to pathological stress, may explain variable responses to PKG1alpha pathway stimulation in heart disease | Prevention of PKG1α oxidation augments cardioprotection in the stressed heart.
Nakamura T, Ranek MJ, Lee DI, Shalkey Hahn V, Kim C, Eaton P, Kass DA., Free PMC Article | 08/15/2015 |
| Data show that cGMP-dependent kinase (cGK-Ialpha) knockdown partially rescued TNF-alpha-induced decrease in 42-kDa cGMP-dependent protein kinase-anchoring protein (GKAP42) and impairment of insulin signals. | Tumor necrosis factor (TNF)-α-induced repression of GKAP42 protein levels through cGMP-dependent kinase (cGK)-Iα causes insulin resistance in 3T3-L1 adipocytes.
Ando Y, Shinozawa Y, Iijima Y, Yu BC, Sone M, Ooi Y, Watanaka Y, Chida K, Hakuno F, Takahashi S., Free PMC Article | 05/16/2015 |
| miR-20a expression is up-regulated in response to hypoxia in both mouse and human pulmonary arterial smooth muscle cells | MiR-20a regulates the PRKG1 gene by targeting its coding region in pulmonary arterial smooth muscle cells.
Zeng Y, Pan Y, Liu H, Kang K, Wu Y, Hui G, Peng W, Ramchandran R, Raj JU, Gou D. | 02/21/2015 |
| These findings characterize PKG as a novel regulator of AR-mediated transcription by enhancing AR cofactor p44/WDR77's function. | cGMP-dependent protein kinase Iβ interacts with p44/WDR77 to regulate androgen receptor-driven gene expression.
Zhou L, Hosohata K, Gao S, Gu Z, Wang Z., Free PMC Article | 01/31/2015 |
| A functional leucine zipper domain in PKG-1alpha is essential for maintenance of a low pulmonary vascular tone in normoxia. | PKG-1α leucine zipper domain defect increases pulmonary vascular tone: implications in hypoxic pulmonary hypertension.
Ramchandran R, Raghavan A, Geenen D, Sun M, Bach L, Yang Q, Raj JU., Free PMC Article | 11/29/2014 |