| PPP3CB Inhibits Cell Proliferation and the Warburg Effect in Bladder Cancer by Blocking PDHK1. | PPP3CB Inhibits Cell Proliferation and the Warburg Effect in Bladder Cancer by Blocking PDHK1.
Qiu X, Jiang Z, Luo Y, Tian D, Song T, Li Q. | 03/4/2024 |
| Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses. | Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses.
Miura E, Watanabe M. | 07/9/2022 |
| Calcineurin (PPP3CB) regulates angiotensin II-dependent vascular remodelling by potentiating EGFR signalling in mice. | Calcineurin (PPP3CB) regulates angiotensin II-dependent vascular remodelling by potentiating EGFR signalling in mice.
Nolze A, Köhler C, Ruhs S, Quarch K, Strätz N, Gekle M, Grossmann C. | 11/6/2021 |
| Calcineurin Abeta-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy. | Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy.
Li X, Li J, Martinez EC, Froese A, Passariello CL, Henshaw K, Rusconi F, Li Y, Yu Q, Thakur H, Nikolaev VO, Kapiloff MS., Free PMC Article | 09/4/2021 |
| Calcineurin A beta mediates hypothalamic astrocytosis in response to acute and chronic high fat diet exposure. | Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice.
Pfuhlmann K, Schriever SC, Legutko B, Baumann P, Harrison L, Kabra DG, Baumgart EV, Tschöp MH, Garcia-Caceres C, Pfluger PT., Free PMC Article | 04/13/2019 |
| Transient high ductal pressure produces pancreatic inflammation and loss of tight junction integrity via calcineurin signaling. | Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice.
Wen L, Javed TA, Yimlamai D, Mukherjee A, Xiao X, Husain SZ., Free PMC Article | 10/27/2018 |
| NFAT is activated through calcineurin and interacts with NFsmall ka, CyrillicB after P. aeruginosa lung infection, and contributes to the host inflammatory response. | The calcineurin-NFAT axis contributes to host defense during Pseudomonas aeruginosa lung infection.
Pang Z, Junkins RD, MacNeil AJ, McCormick C, Cheng Z, Chen WM, Lin TJ. | 12/16/2017 |
| CnAbeta1 is mainly localized at the Golgi apparatus through its C-terminal domain. CnAbeta1 is needed for mTORC2 localization and activation at the cellular membranes. CnAbeta1 regulates differentiation of mouse embryonic stem cells to mesoderm. | The Calcineurin Variant CnAβ1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation.
Gómez-Salinero JM, López-Olañeta MM, Ortiz-Sánchez P, Larrasa-Alonso J, Gatto A, Felkin LE, Barton PJR, Navarro-Lérida I, Del Pozo MÁ, García-Pavía P, Sundararaman B, Giovinazo G, Yeo GW, Lara-Pezzi E. | 10/28/2017 |
| Data indicate that calcineurin (CnAalpha-/- or CnAbeta-/-) is required for pathological but not compensatory renal hypertrophy. | Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent.
Williams CR, Wynne BM, Walker M, Hoover RS, Gooch JL., Free PMC Article | 08/29/2015 |
| CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling. | Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin.
Mehta S, Aye-Han NN, Ganesan A, Oldach L, Gorshkov K, Zhang J., Free PMC Article | 05/16/2015 |
| CnAbeta/NFAT pathway modulates Nox. | Calcineurin Aβ regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose.
Williams CR, Gooch JL., Free PMC Article | 04/26/2014 |
| Calcineurin regulates degradation of phosphodiesterase 3B, in addition to phosphodiesterase 4D. | Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases.
Suk HY, Zhou C, Yang TT, Zhu H, Yu RY, Olabisi O, Yang X, Brancho D, Kim JY, Scherer PE, Frank PG, Lisanti MP, Calvert JW, Lefer DJ, Molkentin JD, Ghigo A, Hirsch E, Jin J, Chow CW., Free PMC Article | 03/30/2013 |
| loss of beta isoform of calcineurin is sufficient to reproduce aspects of cyclosporine on diabetic renal hypertrophy but not matrix expansion; calcineurin beta appears to be a central mechanism involved in organ hypertrophy | Calcineurin A-β is required for hypertrophy but not matrix expansion in the diabetic kidney.
Reddy RN, Knotts TL, Roberts BR, Molkentin JD, Price SR, Gooch JL., Free PMC Article | 04/21/2012 |
| Results indicate that myospryn functions as a novel inhibitor of the calcineurin signaling pathway in skeletal muscle. | Myospryn is a calcineurin-interacting protein that negatively modulates slow-fiber-type transformation and skeletal muscle regeneration.
Kielbasa OM, Reynolds JG, Wu CL, Snyder CM, Cho MY, Weiler H, Kandarian S, Naya FJ., Free PMC Article | 10/1/2011 |
| Calcineurin Abeta1 shows a unique mode of action that improves cardiac function after myocardial infarction, activating different cardioprotective pathways without inducing maladaptive hypertrophy | Calcineurin splicing variant calcineurin Aβ1 improves cardiac function after myocardial infarction without inducing hypertrophy.
Felkin LE, Narita T, Germack R, Shintani Y, Takahashi K, Sarathchandra P, López-Olañeta MM, Gómez-Salinero JM, Suzuki K, Barton PJ, Rosenthal N, Lara-Pezzi E. | 09/3/2011 |
| A novel-splicing variant of calcineurin Ass CnAss-FK, which is encoded by an intron-retaining mRNA and is deficient in the autoinhibitory domain, is predominantly expressed in mature follicular keratinocytes. | Expression of a constitutively active calcineurin encoded by an intron-retaining mRNA in follicular keratinocytes.
Fujimura A, Michiue H, Nishiki T, Ohmori I, Wei FY, Matsui H, Tomizawa K., Free PMC Article | 07/9/2011 |
| Calcineurin Abeta is important for the production and maintenance of Treg cells and to ensure mature T-cell quiescence. | Divergent effects of calcineurin Aβ on regulatory and conventional T-cell homeostasis.
Doetschman T, Sholl A, Chen Hd, Gard C, Hildeman DA, Bommireddy R., Free PMC Article | 04/16/2011 |
| Results identify a novel signaling process governing G-protein-coupled cAMP signal transduction-opposing actions of the phosphatase calcineurin and the CK1/GSK3beta protein kinases on the phosphodegron-dependent degradation of PDE4D. | Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D.
Zhu H, Suk HY, Yu RY, Brancho D, Olabisi O, Yang TT, Yang X, Zhang J, Moussaif M, Durand JL, Jelicks LA, Kim JY, Scherer PE, Frank PG, Lisanti MP, Calvert JW, Duranski MR, Lefer DJ, Huston E, Baillie GS, Houslay MD, Molkentin JD, Jin J, Chow CW., Free PMC Article | 10/23/2010 |
| calcineurin activation in skeletal muscle increases mitochondrial oxidative function and energy substrate storage, which contributes to enhanced endurance exercise performance | Constitutively active calcineurin in skeletal muscle increases endurance performance and mitochondrial respiratory capacity.
Jiang LQ, Garcia-Roves PM, de Castro Barbosa T, Zierath JR. | 09/13/2010 |
| Plasma renin concentrations were not different in wild-type, calcineurin A-alpha, or A-beta knockout mice. | Inhibition of calcineurin phosphatase promotes exocytosis of renin from juxtaglomerular cells.
Madsen K, Friis UG, Gooch JL, Hansen PB, Holmgaard L, Skøtt O, Jensen BL. | 03/29/2010 |
| Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation. | Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation.
Donaldson C, Eder S, Baker C, Aronovitz MJ, Weiss AD, Hall-Porter M, Wang F, Ackerman A, Karas RH, Molkentin JD, Patten RD., Free PMC Article | 01/21/2010 |
| CnAbeta is also required for the homeostatic survival of naive T cells. | Requirement of calcineurin a beta for the survival of naive T cells.
Manicassamy S, Gupta S, Huang Z, Molkentin JD, Shang W, Sun Z. | 01/21/2010 |
| absence of CnA-alpha but not CnA-beta leads to a defect in normal maturation of the NZ and glomeruli, alterations in the cell cycle, and impaired kidney function | Calcineurin A-alpha but not A-beta is required for normal kidney development and function.
Gooch JL, Toro JJ, Guler RL, Barnes JL., Free PMC Article | 01/21/2010 |
| calcineurin expression is important during myogenesis and fiber-type switching, but not for muscle growth in response to hypertrophic stimuli | Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy.
Parsons SA, Millay DP, Wilkins BJ, Bueno OF, Tsika GL, Neilson JR, Liberatore CM, Yutzey KE, Crabtree GR, Tsika RW, Molkentin JD. | 01/21/2010 |
| Total peripheral T cell numbers were significantly reduced in CnA beta(-/-) mice and were defective in proliferative capacity and IL-2 production in response to PMA/ionomycin and T cell receptor cross-linking. | Defective T cell development and function in calcineurin A beta -deficient mice.
Bueno OF, Brandt EB, Rothenberg ME, Molkentin JD., Free PMC Article | 01/21/2010 |