| Validation of positional candidates Rps6ka6 and Pou3f4 for a locus associated with skeletal muscle mass variability. | Validation of positional candidates Rps6ka6 and Pou3f4 for a locus associated with skeletal muscle mass variability.
Lekkos K, Bhuiyan AA, Albloshi AMK, Brooks PM, Coate TM, Lionikas A., Free PMC Article | 06/3/2024 |
| Brn4 substantially contributes to cochlear gap junction properties to maintain the proper EP in cochleae, similar to connexin-related deafness. | Deficiency of transcription factor Brn4 disrupts cochlear gap junction plaques in a model of DFN3 non-syndromic deafness.
Kidokoro Y, Karasawa K, Minowa O, Sugitani Y, Noda T, Ikeda K, Kamiya K., Free PMC Article | 06/20/2015 |
| Efnb2 expression was attenuated in Pou3f4 hemizygous null mutants relative to control. | Pou3f4-mediated regulation of ephrin-b2 controls temporal bone development in the mouse.
Raft S, Coate TM, Kelley MW, Crenshaw EB 3rd, Wu DK., Free PMC Article | 06/20/2015 |
| Results show three novel mutations in the POU3F4 gene resulting in profound hearing loss in both humans and mice. | Cytoplasmic mislocalization of POU3F4 due to novel mutations leads to deafness in humans and mice.
Parzefall T, Shivatzki S, Lenz DR, Rathkolb B, Ushakov K, Karfunkel D, Shapira Y, Wolf M, Mohr M, Wolf E, Sabrautzki S, de Angelis MH, Frydman M, Brownstein Z, Avraham KB., Free PMC Article | 01/25/2014 |
| This study indicated a model whereby Pou3f4 in the otic mesenchyme establishes an Eph/ephrin-mediated fasciculation signal that promotes inner radial bundle formation. | Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway.
Coate TM, Raft S, Zhao X, Ryan AK, Crenshaw EB 3rd, Kelley MW., Free PMC Article | 03/10/2012 |
| pou3f4 expression in inner ear might be under the control of distinct regulatory elements that fine-tune the spatio-temporal activity of this gene | Characterization of new otic enhancers of the pou3f4 gene reveal distinct signaling pathway regulation and spatio-temporal patterns.
Robert-Moreno À, Naranjo S, de la Calle-Mustienes E, Gómez-Skarmeta JL, Alsina B., Free PMC Article | 07/9/2011 |
| The effects of Brn-4 on the neuronal differentiation and development of neural stem cells, were investigated. | Effects of Brn-4 on the neuronal differentiation of neural stem cells derived from rat midbrain.
Tan XF, Qin JB, Jin GH, Tian ML, Li HM, Zhu HX, Zhang XH, Shi JH, Huang Z. | 11/27/2010 |
| Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis | Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis.
Braunstein EM, Monks DC, Aggarwal VS, Arnold JS, Morrow BE., Free PMC Article | 01/21/2010 |
| Tbx1 and Brn4 function in signaling from the periotic mesenchyme to the otic vesicle to direct proper coiling of the cochlear duct. | Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation.
Braunstein EM, Crenshaw EB 3rd, Morrow BE, Adams JC., Free PMC Article | 01/21/2010 |
| lack of role in regulating Pax6 and Nkx2.2 | The role of Brn4/Pou3f4 and Pax6 in forming the pancreatic glucagon cell identity.
Heller RS, Stoffers DA, Liu A, Schedl A, Crenshaw EB 3rd, Madsen OD, Serup P. | 01/21/2010 |
| late-onset effect of Brn-4 deficiency on the hearing organ of the mouse. About one third of heterozygous female mice revealed late-onset profound deafness at the age of 1 year. | Late-onset hearing loss in a mouse model of DFN3 non-syndromic deafness: morphologic and immunohistochemical analyses.
Xia AP, Kikuchi T, Minowa O, Katori Y, Oshima T, Noda T, Ikeda K. | 01/21/2010 |
| a transcription factor targeted to the early mouse pancreas induces ectopic glucagon gene expression | Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells.
Hussain MA, Miller CP, Habener JF. | 01/21/2010 |