| DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1. | DNA polymerase beta connects tumorigenicity with the circadian clock in liver cancer through the epigenetic demethylation of Per1.
Chen S, Zhang W, Li X, Cao Z, Liu C., Free PMC Article | 02/1/2024 |
| Polbeta/XRCC1 heterodimerization dictates DNA damage recognition and basal Polbeta protein levels without interfering with mouse viability or fertility. | Polβ/XRCC1 heterodimerization dictates DNA damage recognition and basal Polβ protein levels without interfering with mouse viability or fertility.
Koczor CA, Thompson MK, Sharma N, Prakash A, Sobol RW., Free PMC Article | 03/4/2023 |
| Polbeta modulates the expression of type I interferon via STING pathway. | Polβ modulates the expression of type I interferon via STING pathway.
Huang M, Wu T, Liu R, Wang M, Shi M, Xin J, Shao S, Zhao X, Ma Y, Gu L, Guo Z, Pan F. | 08/13/2022 |
| The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation. | The hematopoietic compartment is sufficient for lupus development resulting from the POLB-Y265C mutation.
Rahim T, Levinson MA, Carufe KEW, Burak M, Meas R, Maher S, Bothwell ALM, Gades N, Sweasy JB., Free PMC Article | 05/14/2022 |
| DNA polymerase beta deficiency promotes the occurrence of esophageal precancerous lesions in mice. | DNA polymerase β deficiency promotes the occurrence of esophageal precancerous lesions in mice.
Qin J, Zhu Y, Ding Y, Niu T, Zhang Y, Wu H, Zhu L, Yuan B, Qiao Y, Lu J, Liu K, Dong Z, Jin G, Chen X, Zhao J., Free PMC Article | 01/22/2022 |
| DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model. | DNA glycosylase deficiency leads to decreased severity of lupus in the Polb-Y265C mouse model.
Paluri SL, Burak M, Senejani AG, Levinson M, Rahim T, Clairmont K, Kashgarian M, Alvarado-Cruz I, Meas R, Cardó-Vila M, Zeiss C, Maher S, Bothwell ALM, Coskun E, Kant M, Jaruga P, Dizdaroglu M, Stephen Lloyd R, Sweasy JB., Free PMC Article | 10/16/2021 |
| DNA polymerase beta outperforms DNA polymerase gamma in key mitochondrial base excision repair activities. | DNA polymerase β outperforms DNA polymerase γ in key mitochondrial base excision repair activities.
Baptiste BA, Baringer SL, Kulikowicz T, Sommers JA, Croteau DL, Brosh RM Jr, Bohr VA., Free PMC Article | 08/14/2021 |
| DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair | Deployment of DNA polymerases beta and lambda in single-nucleotide and multinucleotide pathways of mammalian base excision DNA repair.
Thapar U, Demple B., Free PMC Article | 07/20/2019 |
| The Polb/p53 double knockout animals exclusively developed medulloblastoma and no other type of brain tumor. | DNA polymerase β deficiency in the p53 null cerebellum leads to medulloblastoma formation.
Kim J, Kim J, Lee Y. | 05/11/2019 |
| To evaluate whether Polb might be causative in senescence induction, the study evaluated the impact of murine Polb nullizygosity on senescence. Unexposed DNA polymerase beta-null primary fibroblasts exhibit a robust increase in the number of senescent cells compared to wild-type (11-fold, P < 0.001), demonstrating that loss DNA polymerase betais sufficient to induce senescence. | Loss of DNA polymerase β induces cellular senescence.
Ahmed AA, Smoczer C, Pace B, Patterson D, Cress Cabelof D., Free PMC Article | 01/12/2019 |
| Mitochondria from pol beta-deficient mouse fibroblasts had compromised DNA repair and showed elevated levels of superoxide radicals after hydrogen peroxide treatment. Mitochondria in pol beta-deficient fibroblasts displayed altered morphology by electron microscopy. | DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria.
Prasad R, Çağlayan M, Dai DP, Nadalutti CA, Zhao ML, Gassman NR, Janoshazi AK, Stefanick DF, Horton JK, Krasich R, Longley MJ, Copeland WC, Griffith JD, Wilson SH., Free PMC Article | 12/30/2017 |
| pol beta contains a specific NLS sequence in the N-terminal lyase domain that promotes transport of the protein independent of its interaction partners. Active nuclear uptake allows development of a nuclear/cytosolic concentration gradient against a background of passive diffusion. | DNA polymerase β contains a functional nuclear localization signal at its N-terminus.
Kirby TW, Gassman NR, Smith CE, Zhao ML, Horton JK, Wilson SH, London RE., Free PMC Article | 10/7/2017 |
| Analyses of DNA damage and apoptosis revealed significantly greater degeneration of olfactory bulb neurons in transgenic Alzheimer's (3xTgAD)/Polbeta(+/-) mice compared to 3xTgAD mice. | DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease.
Misiak M, Vergara Greeno R, Baptiste BA, Sykora P, Liu D, Cordonnier S, Fang EF, Croteau DL, Mattson MP, Bohr VA., Free PMC Article | 06/10/2017 |
| pol beta plays an important role in bypassing a 5',8-cyclo-dA during DNA replication and repair. | Bypass of a 5',8-cyclopurine-2'-deoxynucleoside by DNA polymerase β during DNA replication and base excision repair leads to nucleotide misinsertions and DNA strand breaks.
Jiang Z, Xu M, Lai Y, Laverde EE, Terzidis MA, Masi A, Chatgilialoglu C, Liu Y., Free PMC Article | 05/7/2016 |
| we show here that heterozygosity for a Y265C mutation in Polbeta, a key polymerase in the BER pathway, is enough to significantly reduce both the number of expansions seen in paternal gametes and the extent of somatic expansion in some tissues | Heterozygosity for a hypomorphic Polβ mutation reduces the expansion frequency in a mouse model of the Fragile X-related disorders.
Lokanga RA, Senejani AG, Sweasy JB, Usdin K., Free PMC Article | 04/16/2016 |
| The aberrant DNA replication mediated by the PCNA-DNA pol-b complex induces p53-dependent neuronal cell death | Proliferating cell nuclear antigen binds DNA polymerase-β and mediates 1-methyl-4-phenylpyridinium-induced neuronal death.
Zhang Z, Zhang Z, Wang H, Zhang G, Hu D, Xiong J, Xiong N, Wang T, Cao X, Mao L., Free PMC Article | 05/16/2015 |
| Y265C POLB mutation leads to several pathologies associated with SLE and short CDR3 regions during VDJ recombination in B cells. | Mutation of POLB causes lupus in mice.
Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB., Free PMC Article | 09/27/2014 |
| Pol beta deficiency could enable ROS accumulation. | Involvement of DNA polymerase beta in repairing oxidative damages induced by antitumor drug adriamycin.
Liu S, Wu M, Zhang Z. | 08/9/2014 |
| Results show that deficiency of either DNA polymerases beta or lambda or both results in a modest but significant decrease in V region somatic hypermutation (SHM) with no effect on mutation specificity, suggesting no direct role in SHM. | DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.
Schrader CE, Linehan EK, Ucher AJ, Bertocci B, Stavnezer J., Free PMC Article | 07/19/2014 |
| Transient OGG1, APE1, PARP1 and Polbeta expression in an Alzheimer's disease mouse model. | Transient OGG1, APE1, PARP1 and Polβ expression in an Alzheimer's disease mouse model.
Lillenes MS, Støen M, Gómez-Muñoz M, Torp R, Günther CC, Nilsson LN, Tønjum T. | 07/12/2014 |
| Data indicate an association of ovarian stimulation with a downregulation of mRNAs encoding the base excision repair proteins APEX1 and POLB as well as the 5-methyl-CpG-binding domain protein MBD3 in individual morula embryos. | The impact of ovarian stimulation on the expression of candidate reprogramming genes in mouse preimplantation embryos.
Linke M, May A, Reifenberg K, Haaf T, Zechner U. | 04/6/2013 |
| Overexpression of Pol beta could reduce oxidative damage and protect cells from hydroquinone genotoxicity. | [Effects of DNA polymerase beta on certain genotoxicity of mouse fibroblast cell induced by hydroquinone].
Chen C, Lai Y, Wu M, Zhang Z. | 02/2/2013 |
| Polbeta could play a role in protecting cell lines from genotoxicity and genetic instability induced by benzo(a)pyrene. | [Effects of DNA polymerase beta on the genotoxicity and genetic instability induced by benzo(a)pyrene].
Yang M, Wu M, Cui J, Chen C, Zhang ZZ. | 01/12/2013 |
| Polbeta could protect cells from apoptosis induced by hydroquinone through decrease of ROS level and depolarization of mitochondria. | [Effect of DNA polymerase beta on apoptosis and mitochondrial membrane potential induced by hydroquinone, a metabolite of benzene].
Chen C, Yang M, Zhang ZZ, Wu M, Deng WW. | 09/15/2012 |
| SAF-A interacts with BRG1 and both components are required for RNA Polymerase II Mediated Transcription | SAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcription.
Vizlin-Hodzic D, Runnberg R, Ryme J, Simonsson S, Simonsson T., Free PMC Article | 07/21/2012 |