| CCL21-Ser expression in melanoma cells recruits CCR7[+] naive T cells to tumor tissues and promotes tumor growth. | CCL21-Ser expression in melanoma cells recruits CCR7(+) naïve T cells to tumor tissues and promotes tumor growth.
Miyamoto M, Kawato Y, Fujie R, Kurowarabe K, Fujiwara K, Nobusawa R, Hayashi R, Iida K, Ohigashi I, Hayasaka H., Free PMC Article | 09/6/2023 |
| The Important Role of the Chemokine Axis CCR7-CCL19 and CCR7-CCL21 in the Pathophysiology of the Immuno-inflammatory Response in Dry Eye Disease. | The Important Role of the Chemokine Axis CCR7-CCL19 and CCR7-CCL21 in the Pathophysiology of the Immuno-inflammatory Response in Dry Eye Disease.
Wang T, Li W, Cheng H, Zhong L, Deng J, Ling S. | 12/4/2021 |
| ACKR4 restrains antitumor immunity by regulating CCL21. | ACKR4 restrains antitumor immunity by regulating CCL21.
Whyte CE, Osman M, Kara EE, Abbott C, Foeng J, McKenzie DR, Fenix KA, Harata-Lee Y, Foyle KL, Boyle ST, Kochetkova M, Aguilera AR, Hou J, Li XY, Armstrong MA, Pederson SM, Comerford I, Smyth MJ, McColl SR., Free PMC Article | 02/20/2021 |
| CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults. | CCL21/CCR7 axis regulating juvenile cartilage repair can enhance cartilage healing in adults.
Joutoku Z, Onodera T, Matsuoka M, Homan K, Momma D, Baba R, Hontani K, Hamasaki M, Matsubara S, Hishimura R, Iwasaki N., Free PMC Article | 10/3/2020 |
| Data indicate the nonredundant role of chemokine (C-C motif) ligand 21A (serine) (CCL21Ser)-encoding Ccl21a in the establishment of self-tolerance in T cells in the thymic medulla | Essential role of CCL21 in establishment of central self-tolerance in T cells.
Kozai M, Kubo Y, Katakai T, Kondo H, Kiyonari H, Schaeuble K, Luther SA, Ishimaru N, Ohigashi I, Takahama Y., Free PMC Article | 10/7/2017 |
| Results suggest that baicalin exerts an inhibitory effect on airway inflammation, and this effect may be associated with the inhibition of CCR7 and its ligands, CCL19 and CCL21, as well as on the nuclear factor-Kappa B (NF-kappaB) pathway in a mouse model of asthma. | Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21.
Liu J, Wei Y, Luo Q, Xu F, Zhao Z, Zhang H, Lu L, Sun J, Liu F, Du X, Li M, Wei K, Dong J. | 03/25/2017 |
| Intralymphatic CCL21 promotes tissue egress of dendritic cells through afferent lymphatic vessels. | Intralymphatic CCL21 Promotes Tissue Egress of Dendritic Cells through Afferent Lymphatic Vessels.
Russo E, Teijeira A, Vaahtomeri K, Willrodt AH, Bloch JS, Nitschké M, Santambrogio L, Kerjaschki D, Sixt M, Halin C. | 11/12/2016 |
| the graft site microenvironment plays a critical role in alloimmunity by determining DC trafficking through the CCR7-CCL19/21 axis. | Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis.
Hua J, Stevenson W, Dohlman TH, Inomata T, Tahvildari M, Calcagno N, Pirmadjid N, Sadrai Z, Chauhan SK, Dana R., Free PMC Article | 07/30/2016 |
| Loss of CCL21 signaling and dendritic cell migration is required for development of ileitis in SAMP mice. | SAMP1/YitFc mice develop ileitis via loss of CCL21 and defects in dendritic cell migration.
Mikulski Z, Johnson R, Shaked I, Kim G, Nowyhed H, Goodman W, Chodaczek G, Pizarro TT, Cominelli F, Ley K., Free PMC Article | 05/30/2015 |
| found that lymph node fringes indeed contained physiological gradients of the chemokine CCL21, which depended on the expression of CCRL1, the atypical receptor for the CCR7 ligands CCL19 and CCL21 | The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes.
Ulvmar MH, Werth K, Braun A, Kelay P, Hub E, Eller K, Chan L, Lucas B, Novitzky-Basso I, Nakamura K, Rülicke T, Nibbs RJ, Worbs T, Förster R, Rot A. | 08/9/2014 |
| The data show that CCL21 and CXCR3 have dichotomous functions in traumatic and autoimmune encephalomyelitis-evoked neuropathic pain suggesting | Dichotomy of CCL21 and CXCR3 in nerve injury-evoked and autoimmunity-evoked hyperalgesia.
Schmitz K, Pickert G, Wijnvoord N, Häussler A, Tegeder I. | 02/1/2014 |
| CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells. | CCL21 attenuates HSV-induced inflammation through up-regulation of CD8+ memory cells.
Choi B, Lim HC, Lee ES, Anower AK, Sohn S. | 08/31/2013 |
| These results demonstrate in vivo that the CCL21-CCR7 axis plays a dual role in DC mobilization: promoting both chemotaxis and arrest of DCs on lymphatic endothelium. | DC mobilization from the skin requires docking to immobilized CCL21 on lymphatic endothelium and intralymphatic crawling.
Tal O, Lim HY, Gurevich I, Milo I, Shipony Z, Ng LG, Angeli V, Shakhar G., Free PMC Article | 11/19/2011 |
| CCL21 has a role in sustaining antitumor activity and inhibit lung cancer growth | Novel CCL21-vault nanocapsule intratumoral delivery inhibits lung cancer growth.
Kar UK, Srivastava MK, Andersson A, Baratelli F, Huang M, Kickhoefer VA, Dubinett SM, Rome LH, Sharma S., Free PMC Article | 11/12/2011 |
| Role of CCL19/21 and its possible signaling through CXCR3 in development of metallophilic macrophages in the mouse thymus. | Role of CCL19/21 and its possible signaling through CXCR3 in development of metallophilic macrophages in the mouse thymus.
Milićević NM, Miljković MD, Milićević Z, Labudović-Borović M, Wang X, Laan M, Peterson P, Randall TD, Westermann J., Free PMC Article | 11/5/2011 |
| MAPK pathway is important for CCL21 expression by lymphatic endotheal cells in vitro and in vivo. | Blocking MAPK signaling downregulates CCL21 in lymphatic endothelial cells and impairs contact hypersensitivity responses.
Miyagaki T, Sugaya M, Okochi H, Asano Y, Tada Y, Kadono T, Blauvelt A, Tamaki K, Sato S. | 10/15/2011 |
| Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development. | Neuronal CCL21 up-regulates microglia P2X4 expression and initiates neuropathic pain development.
Biber K, Tsuda M, Tozaki-Saitoh H, Tsukamoto K, Toyomitsu E, Masuda T, Boddeke H, Inoue K., Free PMC Article | 07/9/2011 |
| CCL19 and CCL21 induce prompt Ab responses to antigen, and negatively regulate helper T cell responses in vivo. | Altered antibody production and helper T cell function in mice lacking chemokines CCL19 and CCL21-Ser.
Aritomi K, Kuwabara T, Tanaka Y, Nakano H, Yasuda T, Ishikawa F, Kurosawa H, Kakiuchi T. | 01/8/2011 |
| CCX-CKR(-/-) have a 5-fold increase in the level of CCL21 protein in blood, and 2- to 3-fold increases in CCL19 and CCL21 in peripheral lymph nodes. | The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses.
Comerford I, Nibbs RJ, Litchfield W, Bunting M, Harata-Lee Y, Haylock-Jacobs S, Forrow S, Korner H, McColl SR. | 01/1/2011 |
| In CCL19-deficient mice expressing various levels of CCL21, one copy of Ccl21-ser is sufficient to fully support DC migration during steady state conditions. It is the critical CCR7 ligand regulating DC homeostasis and function in vivo. | CCL21 is sufficient to mediate DC migration, maturation and function in the absence of CCL19.
Britschgi MR, Favre S, Luther SA. | 06/28/2010 |
| VEGFR-3 participates in immune cell traffic from peripheral tissues to secondary lymphoid organs by regulating allograft lymphatic vessel CCL21 production | Targeting lymphatic vessel activation and CCL21 production by vascular endothelial growth factor receptor-3 inhibition has novel immunomodulatory and antiarteriosclerotic effects in cardiac allografts.
Nykänen AI, Sandelin H, Krebs R, Keränen MA, Tuuminen R, Kärpänen T, Wu Y, Pytowski B, Koskinen PK, Ylä-Herttuala S, Alitalo K, Lemström KB. | 05/31/2010 |
| CCR7 ligands CCL19 and CCL21 have novel roles in the generation of T helper (Th)17 cells and in the induction of experimental autoimmune encephalitis. | CCR7 ligands are required for development of experimental autoimmune encephalomyelitis through generating IL-23-dependent Th17 cells.
Kuwabara T, Ishikawa F, Yasuda T, Aritomi K, Nakano H, Tanaka Y, Okada Y, Lipp M, Kakiuchi T. | 01/21/2010 |
| Scya21 induces larger, more organized infiltrates in pancreatic islets than Scya19, is found in lymph nodes and spleen at higher concentrations, and induces lymphotoxin alpha 1 beta 2 expression on naive CD4 T cells. | Differing activities of homeostatic chemokines CCL19, CCL21, and CXCL12 in lymphocyte and dendritic cell recruitment and lymphoid neogenesis.
Luther SA, Bidgol A, Hargreaves DC, Schmidt A, Xu Y, Paniyadi J, Matloubian M, Cyster JG. | 01/21/2010 |
| Secondary lymphoid organ chemokine gene CCL21b, expressed predominantly in nonlymphoid tissue, promotes lymphocyte recruitment to the pancreas of transgenic mice, where it induces formation of lymph node-like structures. | Ectopic expression of the murine chemokines CCL21a and CCL21b induces the formation of lymph node-like structures in pancreas, but not skin, of transgenic mice.
Chen SC, Vassileva G, Kinsley D, Holzmann S, Manfra D, Wiekowski MT, Romani N, Lira SA. | 01/21/2010 |
| Secondary lymphoid organ chemokine (SLC)-induced chloride current is essential for the chemotaxis response mediated by activation of CXCR3 but not CCR7 receptors, indicating that in brain SLC acts via a different receptor system than in lymphoid organs. | Secondary lymphoid tissue chemokine (CCL21) activates CXCR3 to trigger a Cl- current and chemotaxis in murine microglia.
Rappert A, Biber K, Nolte C, Lipp M, Schubel A, Lu B, Gerard NP, Gerard C, Boddeke HW, Kettenmann H. | 01/21/2010 |