| Microglia-mediated demyelination protects against CD8[+] T cell-driven axon degeneration in mice carrying PLP defects. | Microglia-mediated demyelination protects against CD8(+) T cell-driven axon degeneration in mice carrying PLP defects.
Groh J, Abdelwahab T, Kattimani Y, Hörner M, Loserth S, Gudi V, Adalbert R, Imdahl F, Saliba AE, Coleman M, Stangel M, Simons M, Martini R., Free PMC Article | 11/3/2023 |
| Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse. | Proteolipid protein 1 is involved in the regulation of intestinal motility and barrier function in the mouse.
Woods C, Flockton AR, Wallace LE, Keenan CM, Macklin WB, Sharkey KA, Belkind-Gerson J. | 02/23/2023 |
| Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag. | Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag.
Steyer AM, Buscham TJ, Lorenz C, Hümmert S, Eichel-Vogel MA, Schadt LC, Edgar JM, Köster S, Möbius W, Nave KA, Werner HB. | 01/28/2023 |
| Identifying oligodendrocyte enhancers governing Plp1 expression. | Identifying oligodendrocyte enhancers governing Plp1 expression.
Kim D, An H, Fan C, Park Y., Free PMC Article | 04/2/2022 |
| Identity and lineage fate of proteolipid protein 1 gene (Plp1)-expressing cells in the embryonic murine spinal cord. | Identity and lineage fate of proteolipid protein 1 gene (Plp1)-expressing cells in the embryonic murine spinal cord.
Guo S, Wang Y, Wang A. | 09/4/2021 |
| Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease. | Suppression of proteolipid protein rescues Pelizaeus-Merzbacher disease.
Elitt MS, Barbar L, Shick HE, Powers BE, Maeno-Hikichi Y, Madhavan M, Allan KC, Nawash BS, Gevorgyan AS, Hung S, Nevin ZS, Olsen HE, Hitomi M, Schlatzer DM, Zhao HT, Swayze A, LePage DF, Jiang W, Conlon RA, Rigo F, Tesar PJ., Free PMC Article | 10/31/2020 |
| Young adult Plp1-null mice exhibited subtle but substantial behavioral alterations, indicative of an early impact of mild myelin disruption. | Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone.
Gould EA, Busquet N, Shepherd D, Dietz RM, Herson PS, Simoes de Souza FM, Li A, George NM, Restrepo D, Macklin WB., Free PMC Article | 08/3/2019 |
| This report the mouse model in which maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons. | Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons.
Lüders KA, Nessler S, Kusch K, Patzig J, Jung RB, Möbius W, Nave KA, Werner HB. | 06/15/2019 |
| These results suggest that colitis promotes rapid enteric neurogenesis in adult mice and humans through differentiation of Sox2- and PLP1-expressing cells, which represent enteric glia and/or neural progenitors | Colitis promotes neuronal differentiation of Sox2+ and PLP1+ enteric cells.
Belkind-Gerson J, Graham HK, Reynolds J, Hotta R, Nagy N, Cheng L, Kamionek M, Shi HN, Aherne CM, Goldstein AM., Free PMC Article | 12/22/2018 |
| This study demonstrated that Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2. | Genetic dissection of oligodendroglial and neuronal Plp1 function in a novel mouse model of spastic paraplegia type 2.
Lüders KA, Patzig J, Simons M, Nave KA, Werner HB. | 05/19/2018 |
| The rumpshaker missense mutation in the Plp1 gene gives rise to subcortical myoclonus | Dimethyl fumarate ameliorates myoclonus stemming from protein misfolding in oligodendrocytes.
Southwood CM, Garshott DM, Richardson CR, Seraji-Bozorgzad N, Fribley AM, Gow A. | 03/19/2018 |
| axonal mitochondria, smooth endoplasmic reticulum, and microtubules were characterized in rodent optic nerves where PLP is replaced by the peripheral nerve myelin protein, P0. | Proteolipid protein-deficient myelin promotes axonal mitochondrial dysfunction via altered metabolic coupling.
Yin X, Kidd GJ, Ohno N, Perkins GA, Ellisman MH, Bastian C, Brunet S, Baltan S, Trapp BD., Free PMC Article | 06/3/2017 |
| The observations collectively support the idea that GST-pi(Nuc)/DM-20 mRNA-expressing cells are the progeny of NG2-positive OPCs rather than a novel type of oligodendrocyte-lineage progenitor cells and that DM-20 mRNA expression is dynamically regulated during differentiation of OPCs into oligodendrocytes. | Regulation of DM-20 mRNA expression and intracellular translocation of glutathione-S-transferase pi isoform during oligodendrocyte differentiation in the adult rat spinal cord.
Kitada M, Takeda K, Dezawa M. | 05/13/2017 |
| In the absence of P0, thus, PLP also contributes to myelination by Schwann cells and to the preservation of peripheral axons | Proteolipid protein modulates preservation of peripheral axons and premature death when myelin protein zero is lacking.
Patzig J, Kusch K, Fledrich R, Eichel MA, Lüders KA, Möbius W, Sereda MW, Nave KA, Martini R, Werner HB. | 10/22/2016 |
| while PLP can co-exist with P0 in peripheral nervous system(PNS) myelin, PLP cannot replace P0 as the major structural protein of PNS myelin. | Proteolipid protein cannot replace P0 protein as the major structural protein of peripheral nervous system myelin.
Yin X, Kiryu-Seo S, Kidd GJ, Feltri ML, Wrabetz L, Trapp BD., Free PMC Article | 09/26/2015 |
| Both extracellular and intracellular epitopes of PLP contribute to the pathogenesis of MP4-induced experimental autoimmune encephalomyelitis already in the setting of intact myelin. | Four different synthetic peptides of proteolipid protein induce a distinct antibody response in MP4-induced experimental autoimmune encephalomyelitis.
Recks MS, Grether NB, van der Broeck F, Ganscher A, Wagner N, Henke E, Ergün S, Schroeter M, Kuerten S. | 08/29/2015 |
| The insertion of native PLP into Olg mitochondria of animals with PLP1/Plp1 regulates extracellular pH and adenosine triphosphate. | Insertion of proteolipid protein into oligodendrocyte mitochondria regulates extracellular pH and adenosine triphosphate.
Appikatla S, Bessert D, Lee I, Hüttemann M, Mullins C, Somayajulu-Nitu M, Yao F, Skoff RP., Free PMC Article | 01/10/2015 |
| This study shows for the first time that Plp-null mice exhibit severe early-onset thermal hyperalgesia that is not associated with changes in thermal allodynic behavior. | Mice with a deletion of the major central myelin protein exhibit hypersensitivity to noxious thermal stimuli: involvement of central sensitization.
Petit B, Giraudet F, Béchon C, Bardin L, Avan P, Boespflug-Tanguy O, Bégou M. | 11/22/2014 |
| A novel mechanism sheds light on the immune regulation by which sulfatide-reactive type II natural killer (NK)T cells suppress inflammatory class II histocompatibility-restricted pathogenic CD4+ T cell responses in a T cell-mediated autoimmune disease. | Dendritic cells and anergic type I NKT cells play a crucial role in sulfatide-mediated immune regulation in experimental autoimmune encephalomyelitis.
Maricic I, Halder R, Bischof F, Kumar V., Free PMC Article | 09/20/2014 |
| that an early reactive glia response occurs following mutations in the PLP gene | Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain.
Bachstetter AD, Webster SJ, Van Eldik LJ, Cambi F., Free PMC Article | 06/28/2014 |
| Result suggest that plp1 plays a role either in the structural integrity of oligodendrocyte progenitor cell processes or in their response to extracellular cues that orient process outgrowth. | Expression of proteolipid protein gene in spinal cord stem cells and early oligodendrocyte progenitor cells is dispensable for normal cell migration and myelination.
Harlow DE, Saul KE, Culp CM, Vesely EM, Macklin WB., Free PMC Article | 03/15/2014 |
| PLP significantly suppresses both models of experimental autoimmune encephalitis (EAE)even when there is some evidence of epitope spreading in the myelin oligodendrocyte (MOG)38-50-induced EAE model. | Suppression of MOG- and PLP-induced experimental autoimmune encephalomyelitis using a novel multivalent bifunctional peptide inhibitor.
Badawi AH, Siahaan TJ., Free PMC Article | 11/30/2013 |
| PLP contributes to the high cholesterol content of myelin by association and co-transport in the central nervous system. | A critical role for the cholesterol-associated proteolipids PLP and M6B in myelination of the central nervous system.
Werner HB, Krämer-Albers EM, Strenzke N, Saher G, Tenzer S, Ohno-Iwashita Y, De Monasterio-Schrader P, Möbius W, Moser T, Griffiths IR, Nave KA. | 11/2/2013 |
| Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum. | Olig2/Plp-positive progenitor cells give rise to Bergmann glia in the cerebellum.
Chung SH, Guo F, Jiang P, Pleasure DE, Deng W., Free PMC Article | 08/31/2013 |
| PLP1 mutants inhibit Golgi apparatus to endoplasmic reticulum trafficking and have a role in pathogenesis of Pelizaeus-Merzbacher disease | Depletion of molecular chaperones from the endoplasmic reticulum and fragmentation of the Golgi apparatus associated with pathogenesis in Pelizaeus-Merzbacher disease.
Numata Y, Morimura T, Nakamura S, Hirano E, Kure S, Goto YI, Inoue K., Free PMC Article | 05/18/2013 |