| PLCbeta2 Promotes VEGF-Induced Vascular Permeability. | PLCβ2 Promotes VEGF-Induced Vascular Permeability.
Phoenix KN, Yue Z, Yue L, Cronin CG, Liang BT, Hoeppner LH, Claffey KP., Free PMC Article | 10/8/2022 |
| Mash1-expressing cells may be relevant to type III cells and a subset of PLCbeta2-positive cell differentiation in adult mouse taste buds. | Mash1-expressing cells may be relevant to type III cells and a subset of PLCβ2-positive cell differentiation in adult mouse taste buds.
Hsu CC, Seta Y, Matsuyama K, Kataoka S, Nakatomi M, Toyono T, Gunjigake KK, Kuroishi KN, Kawamoto T. | 09/25/2021 |
| Results show that phospholipase C beta 2 (PLCbeta2) inhibits the virus-induced expression of pro-inflammatory cytokines by interacting with and inhibiting transforming growth factor-beta-activated kinase 1 (TAK1) activation. | PLCβ2 negatively regulates the inflammatory response to virus infection by inhibiting phosphoinositide-mediated activation of TAK1.
Wang L, Zhou Y, Chen Z, Sun L, Wu J, Li H, Liu F, Wang F, Yang C, Yang J, Leng Q, Zhang Q, Xu A, Shen L, Sun J, Wu D, Fang C, Lu H, Yan D, Ge B., Free PMC Article | 04/13/2019 |
| Data suggest the a decrease in migration of hematopoietic stem progenitor cells (HSPCs) can be explained by impaired calcium release in phospholipase C-beta2 (PLC-beta2) knockout (KO) mice and a high baseline level of heme oxygenase 1 (HO-1), an enzyme that negatively regulates cell migration. | The Involvment of Hematopoietic-Specific PLC -β2 in Homing and Engraftment of Hematopoietic Stem/Progenitor Cells.
Adamiak M, Suszynska M, Abdel-Latif A, Abdelbaset-Ismail A, Ratajczak J, Ratajczak MZ., Free PMC Article | 11/11/2017 |
| tristetraprolin is not involved in LPS-mediated destabilization of PLCbeta-2 mRNA in macrophages | 3'UTR AU-Rich Elements (AREs) and the RNA-Binding Protein Tristetraprolin (TTP) Are Not Required for the LPS-Mediated Destabilization of Phospholipase-Cβ-2 mRNA in Murine Macrophages.
Shukla S, Elson G, Blackshear PJ, Lutz CS, Leibovich SJ., Free PMC Article | 05/6/2017 |
| Gnb isoforms control a signaling pathway comprising Rac1, Plcbeta2, and Plcbeta3 leading to LFA-1 activation and neutrophil arrest in vivo | Gnb isoforms control a signaling pathway comprising Rac1, Plcβ2, and Plcβ3 leading to LFA-1 activation and neutrophil arrest in vivo.
Block H, Stadtmann A, Riad D, Rossaint J, Sohlbach C, Germena G, Wu D, Simon SI, Ley K, Zarbock A., Free PMC Article | 06/11/2016 |
| Galphaq-coupled Lpar1 regulates cell proliferation and migration by activating two distinct PLC-beta isozymes, PLC-beta1 and PLC-beta2, respectively. | Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure.
Lee SJ, Leoni G, Neumann PA, Chun J, Nusrat A, Yun CC., Free PMC Article | 06/22/2013 |
| GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4. | GPCR activation of Ras and PI3Kc in neutrophils depends on PLCb2/b3 and the RasGEF RasGRP4.
Suire S, Lécureuil C, Anderson KE, Damoulakis G, Niewczas I, Davidson K, Guillou H, Pan D, Jonathan Clark, Phillip T Hawkins, Stephens L., Free PMC Article | 09/29/2012 |
| A PLCbeta/PI3Kgamma-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis. | A PLCβ/PI3Kγ-GSK3 signaling pathway regulates cofilin phosphatase slingshot2 and neutrophil polarization and chemotaxis.
Tang W, Zhang Y, Xu W, Harden TK, Sondek J, Sun L, Li L, Wu D., Free PMC Article | 02/18/2012 |
| The beta2 isoform mediates close to one-half the chemokine-induced calcium signal in resting and anti-IgM-activated B cells. | Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-β2.
Shirakawa AK, Liao F, Zhang HH, Hedrick MN, Singh SP, Wu D, Farber JM., Free PMC Article | 03/5/2011 |
| Taurine supplementation increases insulin secretion, favouring both influx and internal mobilisation of Ca2+; these effects seem to involve multiple pathways. | Taurine supplementation: involvement of cholinergic/phospholipase C and protein kinase A pathways in potentiation of insulin secretion and Ca2+ handling in mouse pancreatic islets.
Ribeiro RA, Vanzela EC, Oliveira CA, Bonfleur ML, Boschero AC, Carneiro EM. | 11/6/2010 |
| suppression of PLCbeta2 plays an important role in switching M1 macrophages into an M2-like state. | Suppression of PLCbeta2 by endotoxin plays a role in the adenosine A(2A) receptor-mediated switch of macrophages from an inflammatory to an angiogenic phenotype.
Grinberg S, Hasko G, Wu D, Leibovich SJ., Free PMC Article | 03/1/2010 |
| Essential sensory transduction component from taste GPCRs for sweet, bitter, umami tastes | Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.
Zhang Y, Hoon MA, Chandrashekar J, Mueller KL, Cook B, Wu D, Zuker CS, Ryba NJ. | 06/26/2008 |
| Transgenic PLCb2-GFP mice label taste bud cells and olfactory microvillar cells. Immune cells not examined. | Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells.
Kim JW, Roberts C, Maruyama Y, Berg S, Roper S, Chaudhari N. | 06/26/2008 |
| loss of PLCbeta2 and PLCbeta3 significantly impaired T cell migration. | Phospholipase cbeta is critical for T cell chemotaxis.
Bach TL, Chen QM, Kerr WT, Wang Y, Lian L, Choi JK, Wu D, Kazanietz MG, Koretzky GA, Zigmond S, Abrams CS., Free PMC Article | 01/21/2010 |
| Expression of Plcb2 was studied in a cell line during myoblast differentiation. | Expression of phospholipase C beta family isoenzymes in C2C12 myoblasts during terminal differentiation.
Faenza I, Bavelloni A, Fiume R, Santi P, Martelli AM, Maria Billi A, Lo Vasco VR, Manzoli L, Cocco L. | 01/21/2010 |
| confirm role for PLCbeta2 in taste responsiveness to sucrose and to low- to midrange concentrations of quinine and denatonium, and suggest that higher concentrations of the latter two compounds can engage a PLCbeta2-independent taste transduction pathway | PLCbeta2-independent behavioral avoidance of prototypical bitter-tasting ligands.
Dotson CD, Roper SD, Spector AC., Free PMC Article | 01/21/2010 |
| both PLCbeta2/beta3 and PI3Kgamma play vital roles in platelet cytoskeletal dynamics | The relative role of PLCbeta and PI3Kgamma in platelet activation.
Lian L, Wang Y, Draznin J, Eslin D, Bennett JS, Poncz M, Wu D, Abrams CS., Free PMC Article | 01/21/2010 |
| Expesssed by ssensory cells in the olfactory neuroepithelium. | Phosphatidyl-inositide signalling proteins in a novel class of sensory cells in the mammalian olfactory epithelium.
Elsaesser R, Montani G, Tirindelli R, Paysan J. | 01/21/2010 |