| The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons. | The Janus face of endogenous neuronal tPA: promoting self-protection and worsening the death of neighboring neurons.
Prunotto P, Marie P, Lebouvier L, Hommet Y, Vivien D, Ali C., Free PMC Article | 04/17/2024 |
| Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via Plat. | Mechanical induction of osteoanabolic Wnt1 promotes osteoblast differentiation via Plat.
Ahmad M, Haffner-Luntzer M, Schoppa A, Najafova Z, Lukic T, Yorgan TA, Amling M, Schinke T, Ignatius A. | 02/28/2024 |
| Role of tPA in Corticosterone-Induced Apoptosis of Mouse Mural Granulosa and Oviductal Epithelial Cells. | Role of tPA in Corticosterone-Induced Apoptosis of Mouse Mural Granulosa and Oviductal Epithelial Cells.
Hua Q, Cheng H, Yang YQ, An JS, Zhang M, Gong S, Luo MJ, Tan JH., Free PMC Article | 02/16/2023 |
| Blood tissue Plasminogen Activator (tPA) of liver origin contributes to neurovascular coupling involving brain endothelial N-Methyl-D-Aspartate (NMDA) receptors. | Blood tissue Plasminogen Activator (tPA) of liver origin contributes to neurovascular coupling involving brain endothelial N-Methyl-D-Aspartate (NMDA) receptors.
Furon J, Yetim M, Pouettre E, Martinez de Lizarrondo S, Maubert E, Hommet Y, Lebouvier L, Zheng Z, Ali C, Vivien D., Free PMC Article | 02/11/2023 |
| tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-beta. | tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β.
Park L, Zhou J, Koizumi K, Wang G, Anfray A, Ahn SJ, Seo J, Zhou P, Zhao L, Paul S, Anrather J, Iadecola C., Free PMC Article | 02/6/2021 |
| Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity. | Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity.
Zheng Z, Nakamura K, Gershbaum S, Wang X, Thomas S, Bessler M, Schrope B, Krikhely A, Liu RM, Ozcan L, López JA, Tabas I., Free PMC Article | 02/6/2021 |
| This effect requires endothelial NMDAR and is t-PA-dependent. These neurodevelopmental data reinforce the debate regarding safety of molecules with NMDA-antagonist properties administered to preterm and term neonates. | Glutamate controls vessel-associated migration of GABA interneurons from the pial migratory route via NMDA receptors and endothelial protease activation.
Léger C, Dupré N, Aligny C, Bénard M, Lebon A, Henry V, Hauchecorne M, Galas L, Frebourg T, Leroux P, Vivien D, Lecointre M, Marret S, Gonzalez BJ., Free PMC Article | 05/30/2020 |
| Sata suggest that tissue-type plasminogen activator (tPA) regulates nocturnal wheel-running activity, and that tPA differentially affects suprachiasmatic nucleus-driven nocturnal activity rhythms and activity driven by fasting or temporal food restriction. | Regulation of Locomotor activity in fed, fasted, and food-restricted mice lacking tissue-type plasminogen activator.
Krizo JA, Moreland LE, Rastogi A, Mou X, Prosser RA, Mintz EM., Free PMC Article | 08/18/2018 |
| Our findings suggest that isoflurane pretreatment could attenuate tPA-exaggerated brain ischemic injury, by reducing tPA-induced LRP/NF-kappaB/Cox-2 in endothelial cells, endothelial MMP-2 and MMP-9 activation, and subsequent pro-apoptotic molecule in neurons after oxygen/glucose deprivation and reperfusion. | Isoflurane preconditioning inhibits the effects of tissue-type plasminogen activator on brain endothelial cell in an in vitro model of ischemic stroke.
Cheon SY, Kim SY, Kam EH, Lee JH, Kim JM, Kim EJ, Kim TW, Koo BN., Free PMC Article | 03/3/2018 |
| Tissue plasminogen activator was found to be restricted to subsets of excitatory pyramidal glutamatergic neurons. | Tissue Plasminogen Activator Expression Is Restricted to Subsets of Excitatory Pyramidal Glutamatergic Neurons.
Louessard M, Lacroix A, Martineau M, Mondielli G, Montagne A, Lesept F, Lambolez B, Cauli B, Mothet JP, Vivien D, Maubert E. | 01/20/2018 |
| analysis of mutations in genes co-segregating with the targeted Plat allele, including several potential null mutations | Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains.
Szabo R, Samson AL, Lawrence DA, Medcalf RL, Bugge TH., Free PMC Article | 01/6/2018 |
| By mediating the tPA response in macrophages, the NMDA-R provides a pathway by which the fibrinolysis system may regulate innate immunity. | Tissue-type plasminogen activator regulates macrophage activation and innate immunity.
Mantuano E, Azmoon P, Brifault C, Banki MA, Gilder AS, Campana WM, Gonias SL., Free PMC Article | 10/7/2017 |
| Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of intracranial aneurysms. | Vascular Tissue-Type Plasminogen Activator Promotes Intracranial Aneurysm Formation.
Labeyrie PE, Goulay R, Martinez de Lizarrondo S, Hébert M, Gauberti M, Maubert E, Delaunay B, Gory B, Signorelli F, Turjman F, Touzé E, Courthéoux P, Vivien D, Orset C. | 09/30/2017 |
| A model of sustained hyperfibrinolytic state can be obtained in mice by hydrodynamic transfection of a plasmid encoding for tissue-type plasminogen activator (tPA). | Hyperfibrinolysis increases blood-brain barrier permeability by a plasmin- and bradykinin-dependent mechanism.
Marcos-Contreras OA, Martinez de Lizarrondo S, Bardou I, Orset C, Pruvost M, Anfray A, Frigout Y, Hommet Y, Lebouvier L, Montaner J, Vivien D, Gauberti M. | 08/5/2017 |
| While the absence of t-PA confers a more deleterious form of Experimental Autoimmune Encephalomyelitis, neuronal over-expression of t-PA does not overtly protect against this condition with regards to symptom onset or severity of Experimental Autoimmune Encephalomyelitis. | The Influence of Differentially Expressed Tissue-Type Plasminogen Activator in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis.
Dahl LC, Nasa Z, Chung J, Niego B, Tarlac V, Ho H, Galle A, Petratos S, Lee JY, Alderuccio F, Medcalf RL., Free PMC Article | 07/29/2017 |
| mesenchymal stromal cells promote axonal outgrowth via neuronal tPA and synergistically with astrocytic tPA | Mesenchymal Stromal Cells Promote Axonal Outgrowth Alone and Synergistically with Astrocytes via tPA.
Qian JY, Chopp M, Liu Z., Free PMC Article | 07/15/2017 |
| administration of ADAMTS13 5 minutes after occlusion dose-dependently dissolved these t-PA-resistant thrombi resulting in fast restoration of MCA patency and consequently reduced cerebral infarct sizes | ADAMTS13-mediated thrombolysis of t-PA-resistant occlusions in ischemic stroke in mice.
Denorme F, Langhauser F, Desender L, Vandenbulcke A, Rottensteiner H, Plaimauer B, François O, Andersson T, Deckmyn H, Scheiflinger F, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF. | 06/24/2017 |
| strategies contributing to promote either endogenous production of tPA or its associated EGFR-linked signaling pathway may have beneficial effects following brain injuries such as stroke. | Stressed neurons protect themselves by a tissue-type plasminogen activator-mediated EGFR-dependent mechanism.
Lemarchand E, Maubert E, Haelewyn B, Ali C, Rubio M, Vivien D., Free PMC Article | 09/10/2016 |
| Plasminogen activation contributes to wound repair and suggest that adenosine A2A receptor activation promotes wound closure by a mechanism that depends on tPA. | Promotion of Wound Healing by an Agonist of Adenosine A2A Receptor Is Dependent on Tissue Plasminogen Activator.
Montesinos MC, Desai-Merchant A, Cronstein BN. | 08/27/2016 |
| Myeloid-derived Tissue-type plasminogen activator (tPA) promotes macrophage migration through a novel signaling cascade involving FAK, Rac-1, and NF-kappaB. | Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-κB pathways.
Lin L, Jin Y, Mars WM, Reeves WB, Hu K., Free PMC Article | 05/7/2016 |
| the protective effect of neuroserpin maybe independent from its canonical interaction with a tissue-type plasminogen activator | Retina Is Protected by Neuroserpin from Ischemic/Reperfusion-Induced Injury Independent of Tissue-Type Plasminogen Activator.
Gu RP, Fu LL, Jiang CH, Xu YF, Wang X, Yu J., Free PMC Article | 04/23/2016 |
| Erythropoietin protects mouse renal tubular basement membrane by promoting bone marrow cells to generate and secrete miR-144, which, in turn, inhibits activation of the tPA/MMP9-mediated proteolytic network. | Erythropoietin protects the tubular basement membrane by promoting the bone marrow to release extracellular vesicles containing tPA-targeting miR-144.
Zhou Y, Fang L, Yu Y, Niu J, Jiang L, Cao H, Sun Q, Zen K, Dai C, Yang J. | 04/16/2016 |
| tPA activity in V1 can be unmasked following 4 d of monocular deprivation when mice older than 2 months are raised in standard cages by the genetic removal of Lynx1, a negative regulator of adult plasticity. | Unmasking Proteolytic Activity for Adult Visual Cortex Plasticity by the Removal of Lynx1.
Bukhari N, Burman PN, Hussein A, Demars MP, Sadahiro M, Brady DM, Tsirka SE, Russo SJ, Morishita H., Free PMC Article | 01/16/2016 |
| Study shows that the competitive expression or activity of tPA and/or PAI-1, rather than an altered uPA expression, determines the plasmin-mediated Abeta proteolysis in brains affected by Alzheimer's disease | Impacts of aging and amyloid-β deposition on plasminogen activators and plasminogen activator inhibitor-1 in the Tg2576 mouse model of Alzheimer's disease.
Bi Oh S, Suh N, Kim I, Lee JY. | 11/28/2015 |
| Results demonstrate that synaptic potentiation results in tissue plasminogen activator-dependent reelin processing and suggest that extracellular proteolysis of reelin may regulate reelin signaling in the adult brain | Extracellular proteolysis of reelin by tissue plasminogen activator following synaptic potentiation.
Trotter JH, Lussier AL, Psilos KE, Mahoney HL, Sponaugle AE, Hoe HS, Rebeck GW, Weeber EJ., Free PMC Article | 10/17/2015 |