| SerpinB2 deficiency is associated with delayed mammary tumor development and decreased pro-tumorigenic macrophage polarization. | SerpinB2 deficiency is associated with delayed mammary tumor development and decreased pro-tumorigenic macrophage polarization.
Piao YJ, Kim HS, Kim H, Shen J, Moon WK., Free PMC Article | 07/25/2024 |
| Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model. | Plasminogen activator inhibitor-2 (PAI-2) overexpression supports bladder cancer development in PAI-1 knockout mice in N-butyl-N- (4-hydroxybutyl)-nitrosamine- induced bladder cancer mouse model.
Furuya H, Hayashi K, Shimizu Y, Kim N, Tsukikawa Y, Chen R, Sun Y, Chan OTM, Pagano I, Peres R, Hokutan K, Igari F, Chan KS, Rosser CJ., Free PMC Article | 06/26/2021 |
| SerpinB2 Regulates Immune Response in Kidney Injury and Aging. | SerpinB2 Regulates Immune Response in Kidney Injury and Aging.
Sen P, Helmke A, Liao CM, Sörensen-Zender I, Rong S, Bräsen JH, Melk A, Haller H, von Vietinghoff S, Schmitt R., Free PMC Article | 01/2/2021 |
| SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages. | SerpinB2 inhibits migration and promotes a resolution phase signature in large peritoneal macrophages.
Schroder WA, Hirata TD, Le TT, Gardner J, Boyle GM, Ellis J, Nakayama E, Pathirana D, Nakaya HI, Suhrbier A., Free PMC Article | 10/24/2020 |
| Stem cell senescence may enhance SERPINB2 expression, which in turn mediates the effect of SHH on alleviating senescence-induced endometrial stem cell dysfunctions, suggesting that SERPINB2 is a master regulator of SHH signaling during the aging process. | An Endogenous Anti-aging Factor, Sonic Hedgehog, Suppresses Endometrial Stem Cell Aging through SERPINB2.
Cho A, Park SR, Kim SR, Nam S, Lim S, Park CH, Lee HY, Hong IS., Free PMC Article | 02/29/2020 |
| although SerpinB2 has classically been associated with inhibition of uPA-mediated fibrinolysis, we illustrate herein that SerpinB2 (at least in mice) has an unexpected platelet-associated activity in the regulation clot formation. | SerpinB2 deficiency in mice reduces bleeding times via dysregulated platelet activation.
Schroder WA, Le TT, Gardner J, Andrews RK, Gardiner EE, Callaway L, Suhrbier A. | 11/16/2019 |
| The observed reduction of the infarct volume was comparable to the protection obtained by intracerebroventricular injection of recombinant Activin A or SerpinB2 or by stereotactic delivery 3 weeks prior to the injury of a recombinant adeno-associated virus containing an expression cassette for the potent neuroprotective transcription factor Npas4 | Post-injury Nose-to-Brain Delivery of Activin A and SerpinB2 Reduces Brain Damage in a Mouse Stroke Model.
Buchthal B, Weiss U, Bading H., Free PMC Article | 08/17/2019 |
| This study establishes a novel role for SerpinB2 in the stromal compartment in pancreatic ductal adenocarcinoma invasion through regulation of stromal remodelling | SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer.
Harris NLE, Vennin C, Conway JRW, Vine KL, Pinese M, Cowley MJ, Shearer RF, Lucas MC, Herrmann D, Allam AH, Pajic M, Morton JP, Australian Pancreatic Cancer Genome Initiative, Biankin AV, Ranson M, Timpson P, Saunders DN., Free PMC Article | 09/30/2017 |
| Data suggest that the function of keratinocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of urokinase, thereby maintaining the integrity and barrier function of the stratum corneum, particularly during times of skin inflammation | SerpinB2 Deficiency Results in a Stratum Corneum Defect and Increased Sensitivity to Topically Applied Inflammatory Agents.
Schroder WA, Anraku I, Le TT, Hirata TD, Nakaya HI, Major L, Ellis JJ, Suhrbier A. | 05/13/2017 |
| SerpinB2 plays an important role in proteostas | SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation.
Lee JA, Yerbury JJ, Farrawell N, Shearer RF, Constantinescu P, Hatters DM, Schroder WA, Suhrbier A, Wilson MR, Saunders DN, Ranson M., Free PMC Article | 04/30/2016 |
| PAI-2 is a novel regulator of venous thrombus resolution, which modulates several pathways involving both inflammatory and uPA activity mechanisms, distinct from PAI-1 | Enhanced venous thrombus resolution in plasminogen activator inhibitor type-2 deficient mice.
Siefert SA, Chabasse C, Mukhopadhyay S, Hoofnagle MH, Strickland DK, Sarkar R, Antalis TM., Free PMC Article | 07/25/2015 |
| SerpinB2 has previously been implicated as a mediator of DMBA/TPA-induced skin carcinogenesis | Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression.
Rushworth LK, Kidger AM, Delavaine L, Stewart G, van Schelven S, Davidson J, Bryant CJ, Caddye E, East P, Caunt CJ, Keyse SM., Free PMC Article | 04/18/2015 |
| The presence of SerpinB2 on the surface of MPs provides a physiological mechanism whereby cancer cell SerpinB2 can reach the extracellular milieu and access urokinase plasminogen activator (uPA). | Tumor cell-expressed SerpinB2 is present on microparticles and inhibits metastasis.
Schroder WA, Major LD, Le TT, Gardner J, Sweet MJ, Janciauskiene S, Suhrbier A., Free PMC Article | 02/14/2015 |
| Brain metastatic cells from lung cancer and breast cancer express high levels of anti-plasminogen activator (PA) serpins, including neuroserpin and serpin B2, to prevent plasmin generation and its metastasis-suppressive effects. | Serpins promote cancer cell survival and vascular co-option in brain metastasis.
Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, Chaft JE, Kris MG, Huse JT, Brogi E, Massagué J., Free PMC Article | 05/31/2014 |
| C/EBP-beta mediates both constitutive and LPS-induced serpinB2 mRNA expression in mouse embryonic fibroblasts and inflammatory primary macrophages. | The transcription factor C/EBP-β mediates constitutive and LPS-inducible transcription of murine SerpinB2.
Udofa EA, Stringer BW, Gade P, Mahony D, Buzza MS, Kalvakolanu DV, Antalis TM., Free PMC Article | 12/7/2013 |
| Depletion PAI-2 resulted in NLRP3- and ASC-dependent caspase-1 activation and IL-1beta secretion in macrophages upon Toll-like receptor 2 (TLR2) and TLR4 engagement. | TLR-induced PAI-2 expression suppresses IL-1β processing via increasing autophagy and NLRP3 degradation.
Chuang SY, Yang CH, Chou CC, Chiang YP, Chuang TH, Hsu LC., Free PMC Article | 12/7/2013 |
| SerpinB2 can be induced by lentiviral infection in vivo. | Induction of SerpinB2 and Th1/Th2 modulation by SerpinB2 during lentiviral infections in vivo.
Major LD, Partridge TS, Gardner J, Kent SJ, de Rose R, Suhrbier A, Schroder WA., Free PMC Article | 09/7/2013 |
| immune regulation of SerpinB2 expression plays a critical role in the development of Th2-mediated protective immunity against nematode infection by a mechanism involving CCL2 production and macrophage infiltration. | SerpinB2 is critical to Th2 immunity against enteric nematode infection.
Zhao A, Yang Z, Sun R, Grinchuk V, Netzel-Arnett S, Anglin IE, Driesbaugh KH, Notari L, Bohl JA, Madden KB, Urban JF Jr, Antalis TM, Shea-Donohue T., Free PMC Article | 07/27/2013 |
| PAI-2 and TG2 are downstream mediators in the antiapoptotic response triggered upon TBK1 activation. | TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M., Free PMC Article | 03/31/2012 |
| Data show that regulation of Th1 responses thus appears to be a physiological function of inflammation-associated SerpinB2. | A physiological function of inflammation-associated SerpinB2 is regulation of adaptive immunity.
Schroder WA, Le TT, Major L, Street S, Gardner J, Lambley E, Markey K, MacDonald KP, Fish RJ, Thomas R, Suhrbier A. | 05/10/2010 |
| Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver.( | Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver.
Kopitz C, Gerg M, Gansbacher B, Krüger A. | 01/21/2010 |
| SerpinB2 is a cell survival factor that modulates Rb repression of proapoptotic signal transduction | SerpinB2 protection of retinoblastoma protein from calpain enhances tumor cell survival.
Tonnetti L, Netzel-Arnett S, Darnell GA, Hayes T, Buzza MS, Anglin IE, Suhrbier A, Antalis TM., Free PMC Article | 01/21/2010 |
| PAI-2 promotes adipose tissue development in mice via a mechanism independent of its antifibrinolytic effect | Deficiency of plasminogen activator inhibitor-2 impairs nutritionally induced murine adipose tissue development.
Lijnen HR, Frederix L, Scroyen I. | 01/21/2010 |
| during differentiation of epidermal keratinocyte, PAI-2 expresses mainly in the more differentiated keratinocytes and may protect the terminal differentiated keratinocytes from prematuration through inhibiting involucrin expression in cornified envelope | Plasminogen activator inhibitor 2: expression and role in differentiation of epidermal keratinocyte.
Lian X, Yang T. | 01/21/2010 |