| Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment. | Pla2g5 contributes to viral-like-induced lung inflammation through macrophage proliferation and LA/Ffar1 lung cell recruitment.
Koganesawa M, Dwyer DF, Alhallak K, Nagai J, Zaleski K, Samuchiwal S, Hiroaki H, Nishida A, Hirsch TI, Brennan PJ, Puder M, Balestrieri B., | 04/5/2024 |
| Group V Phospholipase A2 Mediates Endothelial Dysfunction and Acute Lung Injury Caused by Methicillin-Resistant Staphylococcus Aureus. | Group V Phospholipase A(2) Mediates Endothelial Dysfunction and Acute Lung Injury Caused by Methicillin-Resistant Staphylococcus Aureus.
Htwe YM, Wang H, Belvitch P, Meliton L, Bandela M, Letsiou E, Dudek SM., Free PMC Article | 10/30/2021 |
| Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A2. | Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A(2).
Koganesawa M, Yamaguchi M, Samuchiwal SK, Balestrieri B., Free PMC Article | 09/11/2021 |
| Lysosome-mediated autophagy pathway contributes to gVPLA2 clearance from lung endothelial cells. | Degradation of group V secretory phospholipase A(2) in lung endothelium is mediated by autophagy.
Meliton LN, Zhu X, Brown M, Epshtein Y, Kawasaki T, Letsiou E, Dudek SM., Free PMC Article | 07/25/2020 |
| macrophage-associated Pla2g5 contributes significantly to type-2 immunity through regulation of IL-33 induction and free fatty acids-driven group 2 innate lymphoid cell activation | Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms.
Yamaguchi M, Samuchiwal SK, Quehenberger O, Boyce JA, Balestrieri B., Free PMC Article | 12/22/2018 |
| Deficiency of GV sPLA2 results in diminished glucose-stimulated insulin secretion in isolated pancreatic beta-cells | The dual role of group V secretory phospholipase A(2) in pancreatic β-cells.
Shridas P, Noffsinger VP, Trumbauer AC, Webb NR., Free PMC Article | 08/4/2018 |
| GV sPLA2 is involved in the maintenance of tubular cell function and integrity, promoting sodium retention through increased cortical (Na+ + K+)-ATPase expression and activity. | Group V Secretory Phospholipase A2 Is Involved in Tubular Integrity and Sodium Handling in the Kidney.
Silva-Filho JL, Peruchetti DB, Moraes-Santos F, Landgraf SS, Silva LS, Sirtoli GM, Zamith-Miranda D, Takiya CM, Pinheiro AA, Diaz BL, Caruso-Neves C., Free PMC Article | 07/16/2016 |
| AdPLA2 plays an important role in promoting tumorigenesis and disease progression by modulating the production of prostaglandins and may serve as a potential therapeutic target in TSC and LAM. | Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis.
Li C, Zhang E, Sun Y, Lee PS, Zhan Y, Guo Y, Osorio JC, Rosas IO, Xu KF, Kwiatkowski DJ, Yu JJ., Free PMC Article | 06/27/2015 |
| PLA2G5 hydrolyzed phosphatidylcholine in fat-overladen low-density lipoprotein to release unsaturated fatty acids, which prevented palmitate-induced M1 macrophage polarization. | The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity.
Sato H, Taketomi Y, Ushida A, Isogai Y, Kojima T, Hirabayashi T, Miki Y, Yamamoto K, Nishito Y, Kobayashi T, Ikeda K, Taguchi R, Hara S, Ida S, Miyamoto Y, Watanabe M, Baba H, Miyata K, Oike Y, Gelb MH, Murakami M., Free PMC Article | 02/14/2015 |
| Key Data shows the role of group v secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling. | Key role of group v secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling.
Henderson WR Jr, Ye X, Lai Y, Ni Z, Bollinger JG, Tien YT, Chi EY, Gelb MH., Free PMC Article | 09/7/2013 |
| Our studies identified a unique function of gV-sPLA2 in activation of macrophages | Group V secretory phospholipase A2 is involved in macrophage activation and is sufficient for macrophage effector functions in allergic pulmonary inflammation.
Ohta S, Imamura M, Xing W, Boyce JA, Balestrieri B., Free PMC Article | 08/31/2013 |
| The impact of group V sPLA(2) deficiency on angiotensin (Ang) II-induced cardiac fibrosis in apoE deficient mice was investigated. | Group V secretory phospholipase A2 enhances the progression of angiotensin II-induced abdominal aortic aneurysms but confers protection against angiotensin II-induced cardiac fibrosis in apoE-deficient mice.
Boyanovsky BB, Bailey W, Dixon L, Shridas P, Webb NR., Free PMC Article | 11/17/2012 |
| The results indicate that the PLA(2) activity also plays a substantial role in protecting cells against oxidant stress caused by an exogenous hydroperoxide. | The roles of peroxidase and phospholipase A2 activities of peroxiredoxin 6 in protecting pulmonary microvascular endothelial cells against peroxidative stress.
Lien YC, Feinstein SI, Dodia C, Fisher AB., Free PMC Article | 09/15/2012 |
| GV sPLA(2) in bone marrow-derived myeloid cells as well as non-myeloid cells, which are likely bronchial epithelial cells, participate in the regulation of the innate immune response to pulmonary infection with E. coli. | Group V phospholipase A2 in bone marrow-derived myeloid cells and bronchial epithelial cells promotes bacterial clearance after Escherichia coli pneumonia.
Degousee N, Kelvin DJ, Geisslinger G, Hwang DM, Stefanski E, Wang XH, Danesh A, Angioni C, Schmidt H, Lindsay TF, Gelb MH, Bollinger J, Payré C, Lambeau G, Arm JP, Keating A, Rubin BB., Free PMC Article | 12/17/2011 |
| Data from cuprizone-induced model of multiple sclerosis suggest that sPLA2 down-regulation during remyelination can limit release of AA and consequent production of pro-inflammatory PGs/TXB2 (which are increased during demyelination). | Time-dependent changes in the brain arachidonic acid cascade during cuprizone-induced demyelination and remyelination.
Palumbo S, Toscano CD, Parente L, Weigert R, Bosetti F., Free PMC Article | 10/1/2011 |
| sPLA(2)-V plays an important role in the pathogenesis of myocardial ischemia reperfusion injury partly in concert with the activation of cPLA(2) | Group V secretory phospholipase A2 plays a pathogenic role in myocardial ischaemia-reperfusion injury.
Yano T, Fujioka D, Saito Y, Kobayashi T, Nakamura T, Obata JE, Kawabata K, Watanabe K, Watanabe Y, Mishina H, Tamaru S, Kugiyama K. | 08/20/2011 |
| agonist-induced MAPK activation leads to Prdx6 phosphorylation and translocation to the cell membrane, where its PLA(2) activity facilitates assembly of the NOX2 complex and activation of the oxidase. | Peroxiredoxin 6 phosphorylation and subsequent phospholipase A2 activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages.
Chatterjee S, Feinstein SI, Dodia C, Sorokina E, Lien YC, Nguyen S, Debolt K, Speicher D, Fisher AB., Free PMC Article | 06/4/2011 |
| expression of group V sPLA(2) in antigen-presenting cells regulates Ag processing and maturation of dendritc cells and contributes to pulmonary inflammation and immune response against D. farinae. | Group V secretory phospholipase A2 reveals its role in house dust mite-induced allergic pulmonary inflammation by regulation of dendritic cell function.
Giannattasio G, Fujioka D, Xing W, Katz HR, Boyce JA, Balestrieri B., Free PMC Article | 10/23/2010 |
| J-774 cells incubated with Group V secretory phospholipase A(2) hydrolyzed-LDL produced more TNF-alpha and IL-6 compared to cells incubated with control-LDL. | Bioactive products generated by group V sPLA(2) hydrolysis of LDL activate macrophages to secrete pro-inflammatory cytokines.
Boyanovsky BB, Li X, Shridas P, Sunkara M, Morris AJ, Webb NR., Free PMC Article | 05/31/2010 |
| Demonstrate the role of sPLA(2)-V in lipopolysaccharide-induced ICAM-1 and VCAM-1 protein overexpression and leukocyte recruitment, supporting the contribution of sPLA(2)-V in the development of inflammatory innate immune responses. | Group V secreted phospholipase A2 contributes to LPS-induced leukocyte recruitment.
Lapointe S, Brkovic A, Cloutier I, Tanguay JF, Arm JP, Sirois MG. | 05/31/2010 |
| sPLA(2), either through pathways comprising Ras/Raf-1/MEK1/ERK1/2 or the classical PKC family, plays an essential role in Mtb-mediated ROS generation and inflammatory mediator release by microglial cells. | Secretory phospholipase A2 plays an essential role in microglial inflammatory responses to Mycobacterium tuberculosis.
Yang CS, Yuk JM, Shin DM, Kang J, Lee SJ, Jo EK. | 01/21/2010 |
| gVPLA(2) is an inducible protein in pla2g5(+/+) mice but not in pla2g5(-/-) mice within 24 h after lipopolysaccharide treatment | Secretory group V phospholipase A2 regulates acute lung injury and neutrophilic inflammation caused by LPS in mice.
Muñoz NM, Meliton AY, Meliton LN, Dudek SM, Leff AR., Free PMC Article | 01/21/2010 |
| role for syndecan-4 in mediating the uptake of LDL modified by group V secretory phospholipase A2, a process implicated in atherosclerotic lesion progression | Syndecan-4 mediates macrophage uptake of group V secretory phospholipase A2-modified LDL.
Boyanovsky BB, Shridas P, Simons M, van der Westhuyzen DR, Webb NR., Free PMC Article | 01/21/2010 |
| group V sPLA(2) regulates phagocytosis through major phagocytic receptors and contributes to the innate immune response against C. albicans by regulating phagocytosis and killing through a mechanism that is likely dependent on phagolysosome fusion | Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans.
Balestrieri B, Maekawa A, Xing W, Gelb MH, Katz HR, Arm JP., Free PMC Article | 01/21/2010 |
| The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo. | The capacity of group V sPLA2 to increase atherogenicity of ApoE-/- and LDLR-/- mouse LDL in vitro predicts its atherogenic role in vivo.
Boyanovsky B, Zack M, Forrest K, Webb NR., Free PMC Article | 01/21/2010 |