| Expression of Pfkfb isoenzymes during in vitro differentiation of mouse embryonic stem cells into insulin-producing cells. | Expression of Pfkfb isoenzymes during in vitro differentiation of mouse embryonic stem cells into insulin-producing cells.
Güzel S, Yalçin A, Gürpinar Y, Güler S., Free PMC Article | 06/6/2024 |
| Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart. | Loss of Cardiac PFKFB2 Drives Metabolic, Functional, and Electrophysiological Remodeling in the Heart.
Harold KM, Matsuzaki S, Pranay A, Loveland BL, Batushansky A, Mendez Garcia MF, Eyster C, Stavrakis S, Chiao YA, Kinter M, Humphries KM., Free PMC Article | 04/12/2024 |
| mTORC2-AKT signaling to PFKFB2 activates glycolysis that enhances stemness and tumorigenicity of intestinal epithelial cells. | mTORC2-AKT signaling to PFKFB2 activates glycolysis that enhances stemness and tumorigenicity of intestinal epithelial cells.
Li M, Wu X, Pan Y, Song M, Yang X, Xu J, Plikus MV, Lv C, Yu L, Yu Z. | 03/14/2024 |
| PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation. | PFKFB2 Inhibits Ferroptosis in Myocardial Ischemia/Reperfusion Injury Through Adenosine Monophosphate-Activated Protein Kinase Activation.
Fu C, Yu S, Liu Z, Wang J, Liu P, Su G. | 08/10/2023 |
| PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages. | PFKFB2-mediated glycolysis promotes lactate-driven continual efferocytosis by macrophages.
Schilperoort M, Ngai D, Katerelos M, Power DA, Tabas I., Free PMC Article | 03/30/2023 |
| Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney. | Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney.
Harley G, Katerelos M, Gleich K, Lee M, Mount PF, Power DA., Free PMC Article | 02/15/2023 |
| HIF-1/AKT Signaling-Activated PFKFB2 Alleviates Cardiac Dysfunction and Cardiomyocyte Apoptosis in Response to Hypoxia. | HIF-1/AKT Signaling-Activated PFKFB2 Alleviates Cardiac Dysfunction and Cardiomyocyte Apoptosis in Response to Hypoxia.
Gao J, Feng W, Lv W, Liu W, Fu C. | 04/13/2021 |
| PP2Acalpha inhibits PFKFB2-induced glycolysis to promote termination of liver regeneration. | PP2Acα inhibits PFKFB2-induced glycolysis to promote termination of liver regeneration.
Tang N, Zhang J, Fu X, Xie W, Qiu Y. | 11/28/2020 |
| In diabetes mellitus type 1 loss of myocardial PFK-2 content as a result of reduced insulin signaling impairs the capacity to dynamically regulate glycolysis and elevates the levels of early glycolytic intermediates. | Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity.
Bockus LB, Matsuzaki S, Vadvalkar SS, Young ZT, Giorgione JR, Newhardt MF, Kinter M, Humphries KM., Free PMC Article | 07/21/2018 |
| he dysfunction at disease onset was accompanied by increased expression of the rate-limiting glycolytic enzyme phosphofructokinase-2 in activated astrocytes, and by selective reduction in spinal mitochondrial complex I activity | Mitochondrial dysfunction is an important cause of neurological deficits in an inflammatory model of multiple sclerosis.
Sadeghian M, Mastrolia V, Rezaei Haddad A, Mosley A, Mullali G, Schiza D, Sajic M, Hargreaves I, Heales S, Duchen MR, Smith KJ., Free PMC Article | 06/2/2018 |
| SGK3 is not required for insulin-induced PFK-2 activation and that this effect is likely mediated by PKBalpha. | Heart 6-phosphofructo-2-kinase activation by insulin requires PKB (protein kinase B), but not SGK3 (serum- and glucocorticoid-induced protein kinase 3).
Mouton V, Toussaint L, Vertommen D, Gueuning MA, Maisin L, Havaux X, Sanchez-Canedo C, Bertrand L, Dequiedt F, Hemmings BA, Hue L, Rider MH. | 10/23/2010 |
| mouse islets expressed PFKFB2 at the mRNA level; PFK-2/FBPase-2 protein rather than its product fructose 2,6-P(2) is the over-riding determinant of glucose-induced insulin secretion through regulation of glucokinase activity or subcellular targeting. | A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.
Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L. | 01/21/2010 |
| Our results demonstrate that in diet-induced obesity, high Fru-2,6-P2 levels in transgenic livers caused changes in hepatic gene expression profiles for key gluconeogenic and lipogenic enzymes. | Overexpression of ubiquitous 6-phosphofructo-2-kinase in the liver of transgenic mice results in weight gain.
Duran J, Navarro-Sabate A, Pujol A, Perales JC, Manzano A, Obach M, Gómez M, Bartrons R. | 01/21/2010 |