| Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha. | Genetic analyses in mouse fibroblast and melanoma cells demonstrate novel roles for PDGF-AB ligand and PDGF receptor alpha.
Kadrmas JL, Beckerle MC, Yoshigi M., Free PMC Article | 05/8/2021 |
| CPEB2-activated PDGFRalpha mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis. | CPEB2-activated PDGFRα mRNA translation contributes to myofibroblast proliferation and pulmonary alveologenesis.
Lai YT, Chao HW, Lai AC, Lin SH, Chang YJ, Huang YS., Free PMC Article | 09/12/2020 |
| The authors' observations demonstrate the previously unappreciated postnatal role of PDGFA/PDGFRalpha in controlling elastogenic gene expression via a secondary tier of signaling networks composed of EGF and TGFbeta. | Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis.
Li C, Lee MK, Gao F, Webster S, Di H, Duan J, Yang CY, Bhopal N, Peinado N, Pryhuber G, Smith SM, Borok Z, Bellusci S, Minoo P., Free PMC Article | 06/27/2020 |
| PDGF signaling in primitive endoderm cell survival is mediated by PI3K-mTOR through p53-independent mechanism. | PDGF Signaling in Primitive Endoderm Cell Survival Is Mediated by PI3K-mTOR Through p53-Independent Mechanism.
Bessonnard S, Vandormael-Pournin S, Coqueran S, Cohen-Tannoudji M, Artus J. | 06/27/2020 |
| Strenuous running suppresses the synthesis of PDGF-AA in subchondral bone, leading to downregulated PDGF/Akt signal in articular cartilage and thus cartilage degeneration. | Reduced PDGF-AA in subchondral bone leads to articular cartilage degeneration after strenuous running.
Yao Z, Chen P, Wang S, Deng G, Hu Y, Lin Q, Zhang X, Yu B. | 05/30/2020 |
| In summary, the authors concluded that glycosylation-dependent Gal-1/NRP-1 interactions activate TGF-beta and PDGF-like signaling to promote the migration and activation of hepatic stellate cells. | Glycosylation-dependent galectin-1/neuropilin-1 interactions promote liver fibrosis through activation of TGF-β- and PDGF-like signals in hepatic stellate cells.
Wu MH, Chen YL, Lee KH, Chang CC, Cheng TM, Wu SY, Tu CC, Tsui WL., Free PMC Article | 06/8/2019 |
| FSP1-expressiing fibroblasts maintain preadipocyte pool via PDGF signaling and regulate adipose homeostasis. | FSP1-positive fibroblasts are adipogenic niche and regulate adipose homeostasis.
Zhang R, Gao Y, Zhao X, Gao M, Wu Y, Han Y, Qiao Y, Luo Z, Yang L, Chen J, Ge G., Free PMC Article | 05/11/2019 |
| PDGF-A signaling is involved in myofibroblast proliferation and migration. | PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung.
Gouveia L, Betsholtz C, Andrae J. | 05/26/2018 |
| These studies uncover PI3K/AKT2 as a direct PDGFA target that is activated in adipocyte stem cells. | Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis.
Rivera-Gonzalez GC, Shook BA, Andrae J, Holtrup B, Bollag K, Betsholtz C, Rodeheffer MS, Horsley V., Free PMC Article | 07/22/2017 |
| stronger fibrotic effect generated by Platelet-derived growth factor alpha overexpression was mediated by Platelet-derived growth factor receptor alphalpha in cardiac interstitial mesenchymal cells | PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice.
Gallini R, Lindblom P, Bondjers C, Betsholtz C, Andrae J. | 05/20/2017 |
| PDGF-AA impairs endothelium-dependent vasodilation and PDGF-AA mediates BMP4-induced adverse effect on endothelial cell function through SMAD1/5- and SMAD4-dependent mechanisms. | Bone Morphogenic Protein 4-Smad-Induced Upregulation of Platelet-Derived Growth Factor AA Impairs Endothelial Function.
Hu W, Zhang Y, Wang L, Lau CW, Xu J, Luo JY, Gou L, Yao X, Chen ZY, Ma RC, Tian XY, Huang Y. | 07/16/2016 |
| Both cell proliferation and hair inductive activity in murine DPCs are maintained by the synergistic effect of fibroblast growth factor 2 and platelet-derived growth factor receptor alpha. | Synergistic effect of PDGF and FGF2 for cell proliferation and hair inductive activity in murine vibrissal dermal papilla in vitro.
Kiso M, Hamazaki TS, Itoh M, Kikuchi S, Nakagawa H, Okochi H. | 05/7/2016 |
| Primary high invasive Glioma initiating cells SU3 contribute to transformation of adjacent normal host glial cells in local tumor microenvironment possibly via PDGF/PDGFR signaling activation. | Glioma initiating cells contribute to malignant transformation of host glial cells during tumor tissue remodeling via PDGF signaling.
Chen Y, Wang Z, Dai X, Fei X, Shen Y, Zhang M, Wang A, Li X, Wang Z, Huang Q, Dong J. | 10/3/2015 |
| Silencing the Col4-alpha1 gene or disrupting integrin engagement by blocking the antibody reduced the expression of platelet-derived growth factor A (PDGF-A), a potent chemotactic factor for fibroblasts. | Dependence of fibroblast infiltration in tumor stroma on type IV collagen-initiated integrin signal through induction of platelet-derived growth factor.
Chen SY, Lin JS, Lin HC, Shan YS, Cheng YJ, Yang BC. | 09/5/2015 |
| Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts. | Platelet-derived growth factor mediates interleukin-13-induced collagen I production in mouse airway fibroblasts.
Lu J, Zhu Y, Feng W, Pan Y, Li S, Han D, Liu L, Xie X, Wang G, Li M. | 04/18/2015 |
| senescent cells have a role in optimal wound healing through secretion of PDGF-AA | An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.
Demaria M, Ohtani N, Youssef SA, Rodier F, Toussaint W, Mitchell JR, Laberge RM, Vijg J, Van Steeg H, Dollé ME, Hoeijmakers JH, de Bruin A, Hara E, Campisi J., Free PMC Article | 03/21/2015 |
| leading to a PDGF-responsive SRF-driven transcriptional program in the midface | SRF regulates craniofacial development through selective recruitment of MRTF cofactors by PDGF signaling.
Vasudevan HN, Soriano P., Free PMC Article | 03/21/2015 |
| Platelet-derived growth factor plays an integral role in mediating TGF-beta1-dependent mesenchymal stem cell stiffening. | Integral role of platelet-derived growth factor in mediating transforming growth factor-β1-dependent mesenchymal stem cell stiffening.
Ghosh D, Lili L, McGrail DJ, Matyunina LV, McDonald JF, Dawson MR., Free PMC Article | 09/13/2014 |
| GPIbalpha blockade reverses production of interleukin (IL)-1alpha by microglia in response to cerebral ischemia in animals with Streptococcus pneumoniae infection. | Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ibα.
Dénes Á, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H, Francis S, Martinecz B, Nieswandt B, Rothwell NJ, Allan SM. | 08/16/2014 |
| these data uncover an early role of PDGF signaling in primitive endoderm cell survival. | PDGF signaling is required for primitive endoderm cell survival in the inner cell mass of the mouse blastocyst.
Artus J, Kang M, Cohen-Tannoudji M, Hadjantonakis AK., Free PMC Article | 05/10/2014 |
| PDGFA-long isoform plays a critical role in normal development of the lung, intestine, and vertebral column. | Analysis of mice lacking the heparin-binding splice isoform of platelet-derived growth factor A.
Andrae J, Ehrencrona H, Gallini R, Lal M, Ding H, Betsholtz C., Free PMC Article | 11/30/2013 |
| study examined lung fibroblasts (LF) to learn whether PDGFRalpha expression distinguished a population of precursor cells with enhanced proliferative and migratory capabilities; PDGF-A and Shh both increased cytokinesis and chemotaxis of LF but through different mechanisms | Platelet-derived growth factor-A and sonic hedgehog signaling direct lung fibroblast precursors during alveolar septal formation.
McGowan SE, McCoy DM. | 11/2/2013 |
| our studies establish that loss of SMAD1/5 leads to upregulation of PDGFA in ovarian granulosa cells | BMP-specific SMADs function as novel repressors of PDGFA and modulate its expression in ovarian granulosa cells and tumors.
Tripurani SK, Cook RW, Eldin KW, Pangas SA., Free PMC Article | 10/26/2013 |
| Nuclear localization of FoxO3a, an important regulator of p27(kip1) gene-expression, correlates with diminished proliferation of the PDGFRalpha-expressing LF subpopulation. | Platelet-derived growth factor-A regulates lung fibroblast S-phase entry through p27(kip1) and FoxO3a.
McGowan SE, McCoy DM., Free PMC Article | 10/19/2013 |
| PDGF and integrin alphavbeta3 coordinate to have an antagonistic effect in the reactive oxygen species production at focal adhesion sites to regulate cell adhesion and migration. | The antagonistic roles of PDGF and integrin αvβ3 in regulating ROS production at focal adhesions.
Lin LJ, Grimme JM, Sun J, Lu S, Gai L, Cropek DM, Wang Y., Free PMC Article | 09/7/2013 |