| Requirement of hepatic pyruvate carboxylase during fasting, high fat, and ketogenic diet. | Requirement of hepatic pyruvate carboxylase during fasting, high fat, and ketogenic diet.
Selen ES, Rodriguez S, Cavagnini KS, Kim HB, Na CH, Wolfgang MJ., Free PMC Article | 01/14/2023 |
| Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver. | Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.
Cappel DA, Deja S, Duarte JAG, Kucejova B, Iñigo M, Fletcher JA, Fu X, Berglund ED, Liu T, Elmquist JK, Hammer S, Mishra P, Browning JD, Burgess SC., Free PMC Article | 08/15/2020 |
| the MDM2-p53-PC signalling axis links mitochondrial metabolism to insulin secretion and glucose homeostasis, and could represent a therapeutic target in diabetes. | The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells.
Li X, Cheng KKY, Liu Z, Yang JK, Wang B, Jiang X, Zhou Y, Hallenborg P, Hoo RLC, Lam KSL, Ikeda Y, Gao X, Xu A., Free PMC Article | 09/8/2018 |
| These findings indicate that PC-mediated anaplerosis in early-stage NSCLC is required for tumor survival and proliferation. | Pyruvate carboxylase is critical for non-small-cell lung cancer proliferation.
Sellers K, Fox MP, Bousamra M 2nd, Slone SP, Higashi RM, Miller DM, Wang Y, Yan J, Yuneva MO, Deshpande R, Lane AN, Fan TW., Free PMC Article | 04/11/2015 |
| TR4-mediated enhancement of fatty acid synthesis in adipocytes requires increased expression of PC gene | TR4 promotes fatty acid synthesis in 3T3-L1 adipocytes by activation of pyruvate carboxylase expression.
Park SS, Kim SJ, Choi H, Chang C, Kim E. | 01/24/2015 |
| Repression of pyruvate carboxylase could be interpreted as a survival tactic of repressing anabolic pathways to support a redirection of limited carbon units to catabolism rather than storage | Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction.
De Pauw A, Demine S, Tejerina S, Dieu M, Delaive E, Kel A, Renard P, Raes M, Arnould T. | 08/4/2012 |
| Three GC boxes within the proximal promoter of the murine pyruvate carboxylase gene bind Sp1/Sp3 | Functional characterization of the proximal promoter of the murine pyruvate carboxylase gene in hepatocytes: role of multiple gc boxes.
Rojvirat P, Chavalit T, Muangsawat S, Thonpho A, Jitrapakdee S. | 11/26/2011 |
| CREB bind to -1639/-1631 cyclic AMP responsive element of mouse PC gene in vitro and in vivo, respectively. | Identification of the cyclic AMP responsive element (CRE) that mediates transcriptional regulation of the pyruvate carboxylase gene in HepG2 cells.
Thonpho A, Sereeruk C, Rojvirat P, Jitrapakdee S. | 05/3/2010 |
| Islet PC might play a role in the development of type 2 diabetes mellitus where reduction of PC activity might be a consequence of mild hyperglycemia and a cause for severe hyperglycemia. | Reduction of islet pyruvate carboxylase activity might be related to the development of type 2 diabetes mellitus in Agouti-K mice.
Han J, Liu YQ., Free PMC Article | 03/8/2010 |
| Focuses on cloning of human pyruvate carboxylase but also studies pyruvate carboxylase levels in mouse preadipocyte differentiation. | Molecular cloning of a cDNA for human pyruvate carboxylase. Structural relationship to other biotin-containing carboxylases and regulation of mRNA content in differentiating preadipocytes.
Freytag SO, Collier KJ. | 07/1/2009 |
| PPARgamma binds to the functional PPAR-response element of the PC promoter. Impaired in vitro differentiation of white adipocytes of PPARgamma2 knock-out mice was also associated with a marked reduction of PC mRNA | The peroxisome proliferator-activated receptor-gamma regulates murine pyruvate carboxylase gene expression in vivo and in vitro.
Jitrapakdee S, Slawik M, Medina-Gomez G, Campbell M, Wallace JC, Sethi JK, O'rahilly S, Vidal-Puig AJ., Free PMC Article | 01/21/2010 |
| Genomic structure of the pyruvate carboxylase gene is determined. The transcripts are highly expressed in kidney and liver, moderately expressed in heart and testis, and expressed at a low level in spleen. | Structural and promoter regions of the murine pyruvate carboxylase gene.
Jitrapakdee S, Petchamphai N, Sunyakumthorn P, Wallace JC, Boonsaeng V. | 10/11/2001 |