| New observations from this study include altered expression of Pcp2 and Limp2 in Npc1 mutant mice relative to control, with Pcp2 exhibiting multiple isoforms and specific to the cerebella. This study provides valuable insight into pathways altered in the late-stage pathophysiology of NPC1 | Quantitative, Label-Free Proteomics in the Symptomatic Niemann-Pick, Type C1 Mouse Model Using Standard Flow Liquid Chromatography and Thermal Focusing Electrospray Ionization.
Pergande MR, Nguyen TTA, Haney-Ball C, Davidson CD, Cologna SM. | 05/2/2020 |
| A novel Pcp2 transcript is particular to mouse cerebellar Purkinje cells and retinal bipolar neurons. | Expression of a novel splicing variant of Pcp2 in closely related laboratory rodents.
Przybyła MA, Nowacka-Chmielewska MM, Barski JJ. | 02/25/2017 |
| Study describes alternative splicing of the pcp2/L7 gene; biochemical properties of short and long form differ | Developmental upregulation of an alternative form of pcp2 with reduced GDI activity.
Barski JJ, Denker BM, Guan J, Lauth M, Spreafico F, Fertala A, Meyer M., Free PMC Article | 09/13/2014 |
| The results of this study showed that L7-PP2B mice, which suffer from impaired intrinsic plasticity and synaptic potentiation of their Purkinje cells. | Cerebellar potentiation and learning a whisker-based object localization task with a time response window.
Rahmati N, Owens CB, Bosman LW, Spanke JK, Lindeman S, Gong W, Potters JW, Romano V, Voges K, Moscato L, Koekkoek SK, Negrello M, De Zeeuw CI., Free PMC Article | 04/5/2014 |
| This study characterized the Cre-positive retinal ganglion cells in a PCP2 (Purkinje cell protein 2)-cre mouse line. We found that all of the Cre-positive retinal ganglion cells were bistratified retinal ganglion cells. | Characterization of multiple bistratified retinal ganglion cells in a purkinje cell protein 2-Cre transgenic mouse line.
Ivanova E, Lee P, Pan ZH., Free PMC Article | 11/16/2013 |
| both L7 genotype and sex contribute to both acquisition and extinction of fear conditioning is affected in Pcp2(L7) mutants | Sex-dependent behavioral functions of the Purkinje cell-specific Gαi/o binding protein, Pcp2(L7).
Walton JC, Schilling K, Nelson RJ, Oberdick J., Free PMC Article | 04/27/2013 |
| Results suggest that the Pcp2(L7) protein acts as a sensorimotor damper that modulates time- and sense-dependent changes in motor responses. | Sensorimotor enhancement in mouse mutants lacking the Purkinje cell-specific Gi/o modulator, Pcp2(L7).
Iscru E, Serinagaoglu Y, Schilling K, Tian J, Bowers-Kidder SL, Zhang R, Morgan JI, DeVries AC, Nelson RJ, Zhu MX, Oberdick J., Free PMC Article | 01/21/2010 |
| We conclude that PCP2 facilitates cation channels closure in the dark, shortens the rise time of the light response directly, and accelerates the decay time indirectly via the inhibitory network. | Retinal ON bipolar cells express a new PCP2 splice variant that accelerates the light response.
Xu Y, Sulaiman P, Feddersen RM, Liu J, Smith RG, Vardi N., Free PMC Article | 01/21/2010 |
| Two mRNA forms predict two forms of the L7/Pcp-2 protein, which are both highly conserved across species.In mouse both mRNA forms are detectable in dendrites but their relative proportions change during development. | Conservation of the developmentally regulated dendritic localization of a Purkinje cell-specific mRNA that encodes a G-protein modulator: comparison of rodent and human Pcp2(L7) gene structure and expression.
Zhang X, Zhang H, Oberdick J. | 01/21/2010 |
| effect on expression of cre recombinase | L7/Pcp-2-specific expression of Cre recombinase using knock-in approach.
Saito H, Tsumura H, Otake S, Nishida A, Furukawa T, Suzuki N. | 01/21/2010 |
| Pcp2 induces differentiation in PC12 cells, in part through Gbetagamma-mediated Ras and p38 MAPK activation and suggest the potential for similar signalling mechanisms in Purkinje cells. | Purkinje cell protein-2 (Pcp2) stimulates differentiation in PC12 cells by Gbetagamma-mediated activation of Ras and p38 MAPK.
Guan J, Luo Y, Denker BM., Free PMC Article | 01/21/2010 |
| colocalization and association of Galpha(o) and Pcp2 in cerebellum suggest a functional role in regions of synaptic activity. | Association and colocalization of G protein alpha subunits and Purkinje cell protein 2 (Pcp2) in mammalian cerebellum.
Redd KJ, Oberdick J, McCoy J, Denker BM, Luo Y. | 01/21/2010 |
| BAC/Cre transgenic mice have exclusive Cre expression in Purkinje and bipolar cells | Highly restricted expression of Cre recombinase in cerebellar Purkinje cells.
Zhang XM, Ng AH, Tanner JA, Wu WT, Copeland NG, Jenkins NA, Huang JD. | 01/21/2010 |