| A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging. | A dual-color PAX7 and MYF5 in vivo reporter to investigate muscle stem cell heterogeneity in regeneration and aging.
Ancel S, Michaud J, Sizzano F, Tauzin L, Oliveira M, Migliavacca E, Schüler SC, Raja S, Dammone G, Karaz S, Sánchez-García JL, Metairon S, Jacot G, Bentzinger CF, Feige JN, Stuelsatz P., Free PMC Article | 08/6/2024 |
| Interplay between Pitx2 and Pax7 temporally governs specification of extraocular muscle stem cells. | Interplay between Pitx2 and Pax7 temporally governs specification of extraocular muscle stem cells.
Kuriki M, Korb A, Comai G, Tajbakhsh S., Free PMC Article | 06/28/2024 |
| High-mobility group box-1 impedes skeletal muscle regeneration via downregulation of Pax-7 synthesis by increasing miR-342-5p expression. | High-mobility group box-1 impedes skeletal muscle regeneration via downregulation of Pax-7 synthesis by increasing miR-342-5p expression.
Ho TL, Lai YL, Hsu CJ, Su CM, Tang CH., Free PMC Article | 03/14/2024 |
| Melatonin improves muscle injury and differentiation by increasing Pax7 expression. | Melatonin improves muscle injury and differentiation by increasing Pax7 expression.
Su CM, Tsai CH, Chen HT, Wu YS, Chang JW, Yang SF, Tang CH., Free PMC Article | 03/21/2023 |
| PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs. | PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs.
Florkowska A, Meszka I, Nowacka J, Granica M, Jablonska Z, Zawada M, Truszkowski L, Ciemerych MA, Grabowska I., Free PMC Article | 11/22/2021 |
| Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity. | Synthetic essentiality between PTEN and core dependency factor PAX7 dictates rhabdomyosarcoma identity.
Langdon CG, Gadek KE, Garcia MR, Evans MK, Reed KB, Bush M, Hanna JA, Drummond CJ, Maguire MC, Leavey PJ, Finkelstein D, Jin H, Schreiner PA, Rehg JE, Hatley ME., Free PMC Article | 10/16/2021 |
| Epigenetic effects induced by the ectopic expression of Pax7 in 3T3-L1. | Epigenetic effects induced by the ectopic expression of Pax7 in 3T3-L1.
Elgaabari A, Miyawaki-Kuwakado A, Tomimatsu K, Wu Q, Tokunaga K, Izumi W, Suzuki T, Tatsumi R, Nakamura M. | 10/2/2021 |
| Pax7 pioneer factor action requires both paired and homeo DNA binding domains. | Pax7 pioneer factor action requires both paired and homeo DNA binding domains.
Pelletier A, Mayran A, Gouhier A, Omichinski JG, Balsalobre A, Drouin J., Free PMC Article | 08/14/2021 |
| Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas. | Pax7 as molecular switch regulating early and advanced stages of myogenic mouse ESC differentiation in teratomas.
Florkowska A, Meszka I, Zawada M, Legutko D, Proszynski TJ, Janczyk-Ilach K, Streminska W, Ciemerych MA, Grabowska I., Free PMC Article | 06/26/2021 |
| Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice. | Acetylation of PAX7 controls muscle stem cell self-renewal and differentiation potential in mice.
Sincennes MC, Brun CE, Lin AYT, Rosembert T, Datzkiw D, Saber J, Ming H, Kawabe YI, Rudnicki MA., Free PMC Article | 06/12/2021 |
| Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells. | Metformin alleviates muscle wasting post-thermal injury by increasing Pax7-positive muscle progenitor cells.
Yousuf Y, Datu A, Barnes B, Amini-Nik S, Jeschke MG., Free PMC Article | 12/26/2020 |
| Wnt/beta-catenin signaling induces the myomiRs miR-133b and miR-206 to suppress Pax7 and induce the myogenic differentiation program. | Wnt/β-catenin signaling induces the myomiRs miR-133b and miR-206 to suppress Pax7 and induce the myogenic differentiation program.
Cui S, Li L, Mubarokah SN, Meech R. | 08/15/2020 |
| Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD | Pax7, Pax3 and Mamstr genes are involved in skeletal muscle impaired regeneration of dy2J/dy2J mouse model of Lama2-CMD.
Yanay N, Elbaz M, Konikov-Rozenman J, Elgavish S, Nevo Y, Fellig Y, Rabie M, Mitrani-Rosenbaum S, Nevo Y. | 05/23/2020 |
| PAX7, but not MLL1, is required for Myf5 transcriptional activation in committed myoblasts. | MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.
Addicks GC, Brun CE, Sincennes MC, Saber J, Porter CJ, Francis Stewart A, Ernst P, Rudnicki MA., Free PMC Article | 01/4/2020 |
| this study finds that in vivo deployment of the melanotrope enhancer repertoire and chromatin opening requires both Pax7 and Tpit. | Pioneer and nonpioneer factor cooperation drives lineage specific chromatin opening.
Mayran A, Sochodolsky K, Khetchoumian K, Harris J, Gauthier Y, Bemmo A, Balsalobre A, Drouin J., Free PMC Article | 12/28/2019 |
| Asymmetrically dividing muscle stem cells in skeletal muscle give rise to committed cells, where the myogenic determination factor Myf5 is transcriptionally activated by Pax7. | The Dystrophin Glycoprotein Complex Regulates the Epigenetic Activation of Muscle Stem Cell Commitment.
Chang NC, Sincennes MC, Chevalier FP, Brun CE, Lacaria M, Segalés J, Muñoz-Cánoves P, Ming H, Rudnicki MA., Free PMC Article | 09/7/2019 |
| Enhancers opened by Pax7 show a loss of DNA methylation and acquire stable epigenetic memory, as evidenced by binding of nonpioneer factors after Pax7 withdrawal. Transient Pax7 expression is sufficient for stable specification of cell identity. | Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate.
Mayran A, Khetchoumian K, Hariri F, Pastinen T, Gauthier Y, Balsalobre A, Drouin J. | 05/18/2019 |
| Prepubertal depletion of satellite cells in Pax7(CreERT2/+) ; Rosa26(DTA/+) mice reduced myofiber size and myonuclear number, and caused force generation deficits to a similar extent in both fast and slow-contracting muscles. | Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution.
Bachman JF, Klose A, Liu W, Paris ND, Blanc RS, Schmalz M, Knapp E, Chakkalakal JV., Free PMC Article | 02/16/2019 |
| It inhibits adipogenesis. | Paired box 7 inhibits differentiation in 3T3-L1 preadipocytes.
Izumi W, Takuma Y, Ebihara R, Mizunoya W, Tatsumi R, Nakamura M. | 11/17/2018 |
| Transfection experiments showed that the PAX7 splice-site mutation putatively causes nonsense-mediated mRNA decay affecting onlyPAX7 isoform 3. | PAX7 mutation in a syndrome of failure to thrive, hypotonia, and global neurodevelopmental delay.
Proskorovski-Ohayon R, Kadir R, Michalowski A, Flusser H, Perez Y, Hershkovitz E, Sivan S, Birk OS. | 06/23/2018 |
| The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain. | The DUX4 homeodomains mediate inhibition of myogenesis and are functionally exchangeable with the Pax7 homeodomain.
Bosnakovski D, Toso EA, Hartweck LM, Magli A, Lee HA, Thompson ER, Dandapat A, Perlingeiro RCR, Kyba M., Free PMC Article | 06/16/2018 |
| Pax7 activates Zac1 to regulate GPR39 expression in myocytes. | Zac1/GPR39 phosphorylating CaMK-II contributes to the distinct roles of Pax3 and Pax7 in myogenic progression.
Yang Q, Li Y, Zhang X, Chen D. | 05/26/2018 |
| Barx2 and Pax7 regulate the canonical Wnt target gene Axin2, which mediates critical feedback to terminate the transcriptional response to Wnt signals. | Barx2 and Pax7 Regulate Axin2 Expression in Myoblasts by Interaction with β-Catenin and Chromatin Remodelling.
Hulin JA, Nguyen TD, Cui S, Marri S, Yu RT, Downes M, Evans RM, Makarenkova H, Meech R., Free PMC Article | 12/16/2017 |
| Stat3 regulates self-renewal of adult muscle satellite cells during injury-induced muscle regeneration through various partners, such as Pax7. | STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration.
Zhu H, Xiao F, Wang G, Wei X, Jiang L, Chen Y, Zhu L, Wang H, Diao Y, Wang H, Ip NY, Cheung TH, Wu Z. | 11/18/2017 |
| Lkb1 activates the Notch signaling pathway, which subsequently increases Pax7 expression and promotes self-renewal and proliferation while inhibiting differentiation. Mechanistic studies reveal that Lkb1 regulates Notch activation through AMPK-mTOR pathway in myoblasts. | Lkb1 deletion upregulates Pax7 expression through activating Notch signaling pathway in myoblasts.
Shan T, Zhang P, Xiong Y, Wang Y, Kuang S., Free PMC Article | 09/9/2017 |