| Age-dependent mechanical properties of tail tendons in wild-type and mimecan gene-knockout mice - A preliminary study. | Age-dependent mechanical properties of tail tendons in wild-type and mimecan gene-knockout mice - A preliminary study.
Boote C, Ma Q, Goh KL. | 02/14/2023 |
| Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial-mesenchymal transformation in a mouse model of myocarditis. | Osteoglycin silencing exerts inhibitory effects on myocardial fibrosis and epithelial/endothelial-mesenchymal transformation in a mouse model of myocarditis.
Fang Y, Chang Z, Xu Z, Hu J, Zhou H, Yu S, Wan X. | 10/2/2021 |
| Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin. | Overexpressed microRNA-140 inhibits pulmonary fibrosis in interstitial lung disease via the Wnt signaling pathway by downregulating osteoglycin.
Shi S, Li H. | 12/19/2020 |
| Osteoglycin negatively regulates cardiac fibrotic remodelling by attenuating myofibroblast proliferation and migration through LPA3-mediated and Rho/ROCK-dependent inhibition of MT1-MMP translocation, MMP2 activation and EGFR transactivation. | Osteoglycin attenuates cardiac fibrosis by suppressing cardiac myofibroblast proliferation and migration through antagonizing lysophosphatidic acid 3/matrix metalloproteinase 2/epidermal growth factor receptor signalling.
Zuo C, Li X, Huang J, Chen D, Ji K, Yang Y, Xu T, Zhu D, Yan C, Gao P. | 08/3/2019 |
| NK cells promote fetal development through the secretion of growth-promoting factors, pleiotrophin and osteoglycin. | Natural Killer Cells Promote Fetal Development through the Secretion of Growth-Promoting Factors.
Fu B, Zhou Y, Ni X, Tong X, Xu X, Dong Z, Sun R, Tian Z, Wei H. | 12/30/2017 |
| These results reveal a novel pathway in which miR-155 inhibits Ogn expression to regulate proliferation and differentiation of C2C12 myoblast cells. | Osteoglycin inhibition by microRNA miR-155 impairs myogenesis.
Freire PP, Cury SS, de Oliveira G, Fernandez GJ, Moraes LN, da Silva Duran BO, Ferreira JH, Fuziwara CS, Kimura ET, Dal-Pai-Silva M, Carvalho RF., Free PMC Article | 12/9/2017 |
| elevated LIP/LAP ratio robustly increased Ogn expression and cell death under stress by modulating the mitogen-activated protein kinase/activator protein 1 pathway (MAPK/AP-1). | C/EBPβ LIP augments cell death by inducing osteoglycin.
Wassermann-Dozorets R, Rubinstein M., Free PMC Article | 11/25/2017 |
| OGN plays a critical role in negatively regulating ischaemia-induced angiogenesis by inhibiting VEGF-VEGFR2 signalling and thereby attenuating endothelial cells tube formation, proliferation, and migration. | Loss of osteoglycin promotes angiogenesis in limb ischaemia mouse models via modulation of vascular endothelial growth factor and vascular endothelial growth factor receptor 2 signalling pathway.
Wu QH, Ma Y, Ruan CC, Yang Y, Liu XH, Ge Q, Kong LR, Zhang JW, Yan C, Gao PJ. | 10/7/2017 |
| The current study discovered a novel 72-kDa chondroitin sulfate-OGN that is specific for innate immune cells. This variant is able to bind and activate TLR4. | A novel 72-kDa leukocyte-derived osteoglycin enhances the activation of toll-like receptor 4 and exacerbates cardiac inflammation during viral myocarditis.
Rienks M, Papageorgiou A, Wouters K, Verhesen W, Leeuwen RV, Carai P, Summer G, Westermann D, Heymans S., Free PMC Article | 08/19/2017 |
| mimecan is a satiety hormone in adipose tissue, and that mimecan inhibits food intake independently of leptin signaling by inducing IL-1beta and IL-6 expression in the hypothalamus. | Mimecan, a Hormone Abundantly Expressed in Adipose Tissue, Reduced Food Intake Independently of Leptin Signaling.
Cao HM, Ye XP, Ma JH, Jiang H, Li SX, Li RY, Li XS, Guo CC, Wang ZQ, Zhan M, Zuo CL, Pan CM, Zhao SX, Zheng CX, Song HD., Free PMC Article | 11/5/2016 |
| lack of the proteoglycan OGN does not affect the progression of atherosclerosis in mice | Osteoglycin deficiency does not affect atherosclerosis in mice.
Moncayo-Arlandi J, López-García A, Fernández MC, Durán AC, Fernández B. | 08/22/2015 |
| The expression of osteoglycin decreased in the medial, basolateral, and central amygdala regions after chronic immobilization stress in mice. | Decreased expression of extracellular matrix proteins and trophic factors in the amygdala complex of depressed mice after chronic immobilization stress.
Jung S, Lee Y, Kim G, Son H, Lee DH, Roh GS, Kang SS, Cho GJ, Choi WS, Kim HJ., Free PMC Article | 12/22/2012 |
| Osteoglycin may be a crucial humoral bone anabolic factor that is produced by muscle tissues. | Role of osteoglycin in the linkage between muscle and bone.
Tanaka K, Matsumoto E, Higashimaki Y, Katagiri T, Sugimoto T, Seino S, Kaji H., Free PMC Article | 06/9/2012 |
| The temporal-spatial specific pattern and unique co-localization of Dspp, Mepe, Mimecan and Versican suggest they play complementary roles during odontogenesis. | Developmental changes and regional localization of Dspp, Mepe, Mimecan and Versican in postnatal developing mouse teeth.
Hou C, Liu ZX, Tang KL, Wang MG, Sun J, Wang J, Li S. | 05/19/2012 |
| even though there are 3-5 glucocorticoid response elements in the mimecan promoter, glucocorticoid may regulate mimecan transcription indirectly through the synthesis of intermediate proteins | The mechanism of mimecan transcription induced by glucocorticoid in pituitary corticotroph cells.
Zhang XN, Xue LQ, Jiang H, Yang SY, Song HD, Ma QY. | 03/24/2012 |
| Mimecan in pituitary corticotroph cells may regulate adrenocorticotrophic hormone secretion and the hypothalamo-pituitary-adrenal axis | Mimecan in pituitary corticotroph cells may regulate ACTH secretion and the HPAA.
Ma QY, Zhang XN, Jiang H, Wang ZQ, Zhang HJ, Xue LQ, Chen MD, Song HD. | 12/10/2011 |
| High expression of osteoglycin decreases the gelatinase activity of hepatocarcinoma Hca-F cells cultured with extract of lymph node. | High expression of osteoglycin decreases gelatinase activity of murine hepatocarcinoma Hca-F cells.
Cui XN, Tang JW, Song B, Wang B, Chen SY, Hou L., Free PMC Article | 03/22/2010 |
| Ogn-deficient mice, when analyzed by auditory brainstem response and distortion product otoacoustic emissions, have normal hearing thresholds | Expression studies of osteoglycin/mimecan (OGN) in the cochlea and auditory phenotype of Ogn-deficient mice.
Williamson RE, Darrow KN, Giersch AB, Resendes BL, Huang M, Conrad GW, Chen ZY, Liberman MC, Morton CC, Tasheva ES., Free PMC Article | 01/21/2010 |
| In summary, high expression of osteoglycin decreases the metastatic capability of Hca-F to lymph nodes. | High expression of osteoglycin decreases the metastatic capability of mouse hepatocarcinoma Hca-F cells to lymph nodes.
Cui X, Song B, Hou L, Wei Z, Tang J. | 01/21/2010 |
| processing of the prodomain of OGN by BMP-1 potentiates the ability of OGN to modulate the formation of collagen fibrils | Bone morphogenetic protein-1/tolloid-related metalloproteinases process osteoglycin and enhance its ability to regulate collagen fibrillogenesis.
Ge G, Seo NS, Liang X, Hopkins DR, Höök M, Greenspan DS. | 01/21/2010 |