| Activation of ventral tegmental area neurotensin Receptor-1 neurons promotes weight loss. | Activation of ventral tegmental area neurotensin Receptor-1 neurons promotes weight loss.
Perez-Bonilla P, Santiago-Colon K, Matasovsky J, Ramirez-Virella J, Khan R, Garver H, Fink G, Dorrance AM, Leinninger GM., Free PMC Article | 01/29/2022 |
| Anorexia and Fat Aversion Induced by Vertical Sleeve Gastrectomy Is Attenuated in Neurotensin Receptor 1-Deficient Mice. | Anorexia and Fat Aversion Induced by Vertical Sleeve Gastrectomy Is Attenuated in Neurotensin Receptor 1-Deficient Mice.
Ratner C, Shin JH, Dwibedi C, Tremaroli V, Bjerregaard A, Hartmann B, Bäckhed F, Leinninger G, Seeley RJ, Holst B., Free PMC Article | 11/27/2021 |
| Differential allosteric modulation within dopamine D2R - neurotensin NTS1R and D2R - serotonin 5-HT2AR receptor complexes gives bias to intracellular calcium signalling. | Differential allosteric modulation within dopamine D(2)R - neurotensin NTS1R and D(2)R - serotonin 5-HT(2A)R receptor complexes gives bias to intracellular calcium signalling.
Plach M, Schäfer T, Borroto-Escuela DO, Weikert D, Gmeiner P, Fuxe K, Friedland K., Free PMC Article | 11/21/2020 |
| Collectively, this work reveals a cellular mechanism by which neurotensi can directly engage neurotensin receptor 1-expressing DA neurons to modify dopamine signaling. | Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan.
Woodworth HL, Perez-Bonilla PA, Beekly BG, Lewis TJ, Leinninger GM., Free PMC Article | 01/12/2019 |
| The weight loss behaviors are mediated by distinct signaling pathways: Nts action via NtsR1 is essential for the anorectic effect of the lateral hypothalamic Nts circuit, but not for regulation of locomotor or drinking behavior. | Lateral Hypothalamic Neurotensin Neurons Orchestrate Dual Weight Loss Behaviors via Distinct Mechanisms.
Woodworth HL, Beekly BG, Batchelor HM, Bugescu R, Perez-Bonilla P, Schroeder LE, Leinninger GM., Free PMC Article | 07/28/2018 |
| Authors identified a specific subset of VTA DA neurons that express neurotensin receptor-1 (NtsR1) and preferentially comprise mesolimbic, but not mesocortical, DA neurons. | Neurotensin Receptor-1 Identifies a Subset of Ventral Tegmental Dopamine Neurons that Coordinates Energy Balance.
Woodworth HL, Batchelor HM, Beekly BG, Bugescu R, Brown JA, Kurt G, Fuller PM, Leinninger GM., Free PMC Article | 05/19/2018 |
| Data demonstrate that the NTR1 can modulate the methamphetamine-induced striatal neuronal apoptosis independent of body temperature regulation. Possible mechanisms of NTR1 modulating methamphetamine-induced apoptosis include the regulation of dopamine and glutamate neurotransmission in the striatum. | Pharmacological activation of the neurotensin receptor 1 abrogates the methamphetamine-induced striatal apoptosis in the mouse brain.
Liu Q, Hazan A, Grinman E, Angulo JA. | 08/12/2017 |
| The roles of neurotensin and its receptor NTR-1 on sperm capacitation and acrosome reaction in mice are reported. | Neurotensin enhances sperm capacitation and acrosome reaction in mice.
Hiradate Y, Inoue H, Kobayashi N, Shirakata Y, Suzuki Y, Gotoh A, Roh SG, Uchida T, Katoh K, Yoshida M, Sato E, Tanemura K. | 05/14/2016 |
| endogenous changes occur in NT and its receptors across multiple brain regions, and these likely support the emergence of some maternal behaviors. | Endogenous CNS expression of neurotensin and neurotensin receptors is altered during the postpartum period in outbred mice.
Driessen TM, Zhao C, Whittlinger A, Williams H, Gammie SC., Free PMC Article | 09/13/2014 |
| sleep traits and a relationship between Ntsr1 and anxiety and despair behaviors in knockout mice | Altered sleep and affect in the neurotensin receptor 1 knockout mouse.
Fitzpatrick K, Winrow CJ, Gotter AL, Millstein J, Arbuzova J, Brunner J, Kasarskis A, Vitaterna MH, Renger JJ, Turek FW., Free PMC Article | 11/17/2012 |
| Data show that targeted disruption of the neurotensin receptor-1 (Ntsr1) gene reduces susceptibility to colon tumorigenesis. | The neurotensin receptor-1 promotes tumor development in a sporadic but not an inflammation-associated mouse model of colon cancer.
Bugni JM, Rabadi LA, Jubbal K, Karagiannides I, Lawson G, Pothoulakis C., Free PMC Article | 05/26/2012 |
| Data show that NTS1(-/-) mouse is an animal model of schizophrenia, particularly for the dysfunction of the prefrontal cortex. | Similarities in the behavior and molecular deficits in the frontal cortex between the neurotensin receptor subtype 1 knockout mice and chronic phencyclidine-treated mice: relevance to schizophrenia.
Li Z, Boules M, Williams K, Gordillo A, Li S, Richelson E., Free PMC Article | 01/15/2011 |
| Ntsr1 knockout mice showed a higher freezing rate than wild type mice at both first and second exposures under the condition where a relatively weak unconditioned stimulus (footshock) | Lack of neurotensin type 1 receptor facilitates contextual fear memory depending on the memory strength.
Yamada D, Wada E, Amano T, Wada K, Sekiguchi M. | 10/30/2010 |
| Ntsr1 receptor subtype is necessary for normal dopaminergic function. | Hyperactivity of the dopaminergic system in NTS1 and NTS2 null mice.
Liang Y, Boules M, Li Z, Williams K, Miura T, Oliveros A, Richelson E., Free PMC Article | 07/19/2010 |
| These findings support the role for Ntsr1 in the mediation of the metabolic effect of xenin as well as neurotensin. | Role of neurotensin receptor 1 in the regulation of food intake by neuromedins and neuromedin-related peptides.
Kim ER, Mizuno TM. | 03/8/2010 |
| NTR1 does not play a major role in the control of basal thermoregulation, nociception or psychomotor stimulation in mice | Involvement of the neurotensin receptor 1 in the behavioral effects of two neurotensin agonists, NT-2 and NT69L: lack of hypothermic, antinociceptive and antipsychotic actions in receptor knockout mice.
Mechanic JA, Sutton JE, Berson AE, Wu X, Kwan J, Schreiber R, Pang Z, Button DC. | 01/21/2010 |
| These results suggest that, without Ntsr1, synaptic responses from the LA to BLA pyramidal neurons undergo LTP in response to tetanus stimulation through facilitation of D(2)-like receptor-induced activation of NMDA receptors. | Heightened amygdala long-term potentiation in neurotensin receptor type-1 knockout mice.
Amano T, Wada E, Yamada D, Zushida K, Maeno H, Noda M, Wada K, Sekiguchi M. | 01/21/2010 |
| Our data also suggest that the lack of Ntsr1 reduces sensitivity to the anorectic action of leptin, causing hyperphagia and abnormal weight gain. | Impaired anorectic effect of leptin in neurotensin receptor 1-deficient mice.
Kim ER, Leckstrom A, Mizuno TM. | 01/21/2010 |
| [(99m)Tc]Demotensin 6 shows a favourable preclinical profile and further testing in patients is warranted to monitor its eventual applicability as a radiotracer in the diagnostic imaging of NTS1-R-positive tumours. | [99mTc]Demotensin 5 and 6 in the NTS1-R-targeted imaging of tumours: synthesis and preclinical results.
Maina T, Nikolopoulou A, Stathopoulou E, Galanis AS, Cordopatis P, Nock BA. | 01/21/2010 |
| NT and NTR1 are part of network activated after mucosal injuries, and NT stimulates epithelial restitution, at least in part, through a COX-2 dependent pathway. | Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation.
Brun P, Mastrotto C, Beggiao E, Stefani A, Barzon L, Sturniolo GC, Palù G, Castagliuolo I. | 01/21/2010 |
| Neurotensin type 1 receptor does not play a role in NT-induced analgesia, but that it is clearly implicated in thermal and feeding regulation, weight control, and NT-induced hypolocomotion. | Targeted inactivation of the neurotensin type 1 receptor reveals its role in body temperature control and feeding behavior but not in analgesia.
Remaury A, Vita N, Gendreau S, Jung M, Arnone M, Poncelet M, Culouscou JM, Le Fur G, Soubrié P, Caput D, Shire D, Kopf M, Ferrara P. | 01/21/2010 |
| constant activation of NT1 receptor generates an oncogenic regulation | Receptor trafficking via the perinuclear recycling compartment accompanied by cell division is necessary for permanent neurotensin cell sensitization and leads to chronic mitogen-activated protein kinase activation.
Toy-Miou-Leong M, Cortes CL, Beaudet A, Rostène W, Forgez P. | 01/21/2010 |