| Data indicate that APL1-D2 binds Cu(I) and Cu(II) too weakly to sustain catalysis which suggests that it plays no significant role in copper handling in C. elegans. | Quantification of copper binding to amyloid precursor protein domain 2 and its Caenorhabditis elegans ortholog. Implications for biological function.
Leong SL, Young TR, Barnham KJ, Wedd AG, Hinds MG, Xiao Z, Cappai R. | 08/16/2014 |
| present hypothetical models as to how sAPL-1 signaling influences metabolic and developmental pathways. | The secreted Alzheimer-related amyloid precursor protein fragment has an essential role in C. elegans.
Ewald CY, Li C., Free PMC Article | 08/31/2013 |
| [review] Either loss or overexpression of APL-1 will result in lethality, demonstrating the importance of maintaining APL-1 within homeostatic levels, particularly within neurons. | Caenorhabditis elegans as a model organism to study APP function.
Ewald CY, Li C., Free PMC Article | 12/22/2012 |
| Pan-neuronal expression of APL-1, the Caenorhabditis elegans ortholog of APP, disrupts several behaviors, such as olfactory and gustatory learning behavior and touch habituation. | Pan-neuronal expression of APL-1, an APP-related protein, disrupts olfactory, gustatory, and touch plasticity in Caenorhabditis elegans.
Ewald CY, Cheng R, Tolen L, Shah V, Gillani A, Nasrin A, Li C., Free PMC Article | 11/3/2012 |
| signaling of the released APL-1 fragment modulates multiple metabolic states and that APL-1 is required throughout development. | APL-1, the Alzheimer's Amyloid precursor protein in Caenorhabditis elegans, modulates multiple metabolic pathways throughout development.
Ewald CY, Raps DA, Li C., Free PMC Article | 10/27/2012 |
| Cholesterol and lrp-1 are involved in the regulation of synaptic transmission, similar to apl-1. | Regulation of neuronal APL-1 expression by cholesterol starvation.
Wiese M, Antebi A, Zheng H., Free PMC Article | 06/30/2012 |
| a critical cis-regulatory element of apl-1 transcription | Identification of a spatio-temporal enhancer element for the Alzheimer's amyloid precursor protein-like-1 gene in the nematode Caenorhabditis elegans.
Niwa R, Hada K. | 04/2/2011 |
| Loss of apl-1 leads to neurotransmission defects. | Intracellular trafficking and synaptic function of APL-1 in Caenorhabditis elegans.
Wiese M, Antebi A, Zheng H., Free PMC Article | 02/26/2011 |
| the x-ray structure of the E2 domain of APL-1 | Structural characterization of the E2 domain of APL-1, a Caenorhabditis elegans homolog of human amyloid precursor protein, and its heparin binding site.
Hoopes JT, Liu X, Xu X, Demeler B, Folta-Stogniew E, Li C, Ha Y., Free PMC Article | 02/15/2010 |
| apl-1 expression is upregulated during the last larval stage in hypodermal seam cells which is transcriptionally regulated by hbl-1, lin-41 and lin-42. | The expression of the Alzheimer's amyloid precursor protein-like gene is regulated by developmental timing microRNAs and their targets in Caenorhabditis elegans.
Niwa R, Zhou F, Li C, Slack FJ., Free PMC Article | 01/21/2010 |
| APL-1 acts non-cell-autonomously during development. | APL-1, a Caenorhabditis elegans protein related to the human beta-amyloid precursor protein, is essential for viability.
Hornsten A, Lieberthal J, Fadia S, Malins R, Ha L, Xu X, Daigle I, Markowitz M, O'Connor G, Plasterk R, Li C., Free PMC Article | 01/21/2010 |
| The 5' UTR of the Aplp1 gene lacks any type of CAGA box. | Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
Maloney B, Ge YW, Greig N, Lahiri DK. | 01/21/2010 |