| Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion. | Transmembrane serine protease 2 cleaves nidogen 1 and inhibits extrahepatic liver cancer cell migration and invasion.
Ma YB, Qiao JW, Hu X., Free PMC Article | 03/28/2023 |
| Obesity impairs skeletal muscle repair through NID-1 mediated extracellular matrix remodeling by mesenchymal progenitors. | Obesity impairs skeletal muscle repair through NID-1 mediated extracellular matrix remodeling by mesenchymal progenitors.
Pérez-Díaz S, Koumaiha Z, Borok MJ, Aurade F, Pini M, Periou B, Rouault C, Baba-Amer Y, Clément K, Derumeaux G, Authier FJ, Lafuste P, Relaix F. | 01/14/2023 |
| Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche. | Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche.
Balzano M, De Grandis M, Vu Manh TP, Chasson L, Bardin F, Farina A, Sergé A, Bidaut G, Charbord P, Hérault L, Bailly AL, Cartier-Michaud A, Boned A, Dalod M, Duprez E, Genever P, Coles M, Bajenoff M, Xerri L, Aurrand-Lions M, Schiff C, Mancini SJC. | 05/2/2020 |
| Analysis of nidogen-1 and laminin-gamma1 interaction reveals multiple binding modes. | Analysis of nidogen-1/laminin γ1 interaction by cross-linking, mass spectrometry, and computational modeling reveals multiple binding modes.
Lössl P, Kölbel K, Tänzler D, Nannemann D, Ihling CH, Keller MV, Schneider M, Zaucke F, Meiler J, Sinz A., Free PMC Article | 04/2/2016 |
| These studies provide strong evidence for a pathophysiological link between meprin beta and urinary excretion of cleaved nidogen-1 during cisplatin-induced acute kidney injury. | Basement membrane protein nidogen-1 is a target of meprin β in cisplatin nephrotoxicity.
Herzog C, Marisiddaiah R, Haun RS, Kaushal GP., Free PMC Article | 08/15/2015 |
| The C-terminal domains of mouse laminin gamma 1 and nidogen 1 mediate interactions complex formation. | Structural elucidation of full-length nidogen and the laminin-nidogen complex in solution.
Patel TR, Bernards C, Meier M, McEleney K, Winzor DJ, Koch M, Stetefeld J. | 10/18/2014 |
| nidogen-1 is essential to provide an anti-angiogenic environment of differentiated vessels. | Anti-angiogenic effect of the basement membrane protein nidogen-1 in a mouse model of choroidal neovascularization.
Semkova I, Kociok N, Karagiannis D, Nischt R, Smyth N, Paulsson M, Strauß O, Joussen AM. | 02/22/2014 |
| finding demonstrates that nidogens, although homologous proteins, exert their effect on BM assembly through different binding domains, which may in turn result in alterations of BM structure and functions | Different domains in nidogen-1 and nidogen-2 drive basement membrane formation in skin organotypic cocultures.
Bechtel M, Keller MV, Bloch W, Sasaki T, Boukamp P, Zaucke F, Paulsson M, Nischt R. | 12/29/2012 |
| show that loss of nidogen 2, but not of nidogen 1, promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane | Absence of the basement membrane component nidogen 2, but not of nidogen 1, results in increased lung metastasis in mice.
Mokkapati S, Bechtel M, Reibetanz M, Miosge N, Nischt R., Free PMC Article | 05/12/2012 |
| Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain. | Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
Mokkapati S, Fleger-Weckmann A, Bechtel M, Koch M, Breitkreutz D, Mayer U, Smyth N, Nischt R., Free PMC Article | 02/26/2011 |
| This study demonstrates that nidogen-1 is essential for maintenance of normal hippocampal excitability and synaptic plasticity. | Basement membrane protein nidogen-1 shapes hippocampal synaptic plasticity and excitability.
Vasudevan A, Ho MS, Weiergräber M, Nischt R, Schneider T, Lie A, Smyth N, Köhling R. | 08/16/2010 |
| Results suggest a non-structural role for nidogen 1 in wound repair. | Impaired wound healing in mice lacking the basement membrane protein nidogen 1.
Baranowsky A, Mokkapati S, Bechtel M, Krügel J, Miosge N, Wickenhauser C, Smyth N, Nischt R. | 04/12/2010 |
| In capillaries, basement membrane formation is severely impaired in the absence of nidogen-1 and -2, showing an irregular, patchy distribution and a dramatically reduced deposition of collagen IV, perlecan, and particularly laminin-411. | Basement membranes in skin are differently affected by lack of nidogen 1 and 2.
Mokkapati S, Baranowsky A, Mirancea N, Smyth N, Breitkreutz D, Nischt R. | 01/21/2010 |
| structure of the interacting domains reveals a six-bladed Tyr-Trp-Thr-Asp (YWTD) beta-propeller domain in nidogen bound to laminin epidermal-growth-factor-like (LE) modules III3-5 in laminin (LE3-5) | Complex between nidogen and laminin fragments reveals a paradigmatic beta-propeller interface.
Takagi J, Yang Y, Liu JH, Wang JH, Springer TA. | 01/21/2010 |
| nidogen-2 is equivalent to nidogen-1 in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone | Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture.
Nischt R, Schmidt C, Mirancea N, Baranowsky A, Mokkapati S, Smyth N, Woenne EC, Stark HJ, Boukamp P, Breitkreutz D. | 01/21/2010 |
| Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development. | Specific ablation of the nidogen-binding site in the laminin gamma1 chain interferes with kidney and lung development.
Willem M, Miosge N, Halfter W, Smyth N, Jannetti I, Burghart E, Timpl R, Mayer U. | 01/21/2010 |
| short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1, fibulin-1 and fibulin-2 | Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins.
Sasaki T, Göhring W, Mann K, Brakebusch C, Yamada Y, Fässler R, Timpl R. | 01/21/2010 |
| Three- to sevenfold increase in nidogen-2 was observed in heart and muscle of mice with nidogen-1 deficiency. Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 gene. | Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice.
Miosge N, Sasaki T, Timpl R. | 01/21/2010 |
| Nid1 is essential for late stages of lung development and for maintenance and/or integrity of cardiac tissue | Compound genetic ablation of nidogen 1 and 2 causes basement membrane defects and perinatal lethality in mice.
Bader BL, Smyth N, Nedbal S, Miosge N, Baranowsky A, Mokkapati S, Murshed M, Nischt R., Free PMC Article | 01/21/2010 |
| nidogen-1 and -2 have roles in development of the ectodermal basement membrane of the limb bud | Loss of nidogen-1 and -2 results in syndactyly and changes in limb development.
Böse K, Nischt R, Page A, Bader BL, Paulsson M, Smyth N. | 01/21/2010 |
| Laminin gamma3 chain, located in murine basement membranes, binds to nidogen | Laminin gamma3 chain binds to nidogen and is located in murine basement membranes.
Gersdorff N, Kohfeldt E, Sasaki T, Timpl R, Miosge N. | 01/21/2010 |
| expression of the entactin-1 dramatically declined in myogenesis | Differential expression of entactin-1/nidogen-1 and entactin-2/nidogen-2 in myogenic differentiation.
Neu R, Adams S, Munz B. | 01/21/2010 |
| Expression may promote formation of sinusoids after partial hepatectomy. | Transient expression of laminin alpha1 chain in regenerating murine liver: restricted localization of laminin chains and nidogen-1.
Kikkawa Y, Mochizuki Y, Miner JH, Mitaka T. | 01/21/2010 |
| These findings revealed extensive coregulation of nidogen-1 and -2 expression and much more complementary functions of the two nidogens than previously recognized. | Binding of mouse nidogen-2 to basement membrane components and cells and its expression in embryonic and adult tissues suggest complementary functions of the two nidogens.
Salmivirta K, Talts JF, Olsson M, Sasaki T, Timpl R, Ekblom P. | 01/21/2010 |
| The lack of nidogen-1, nidogen-2, or both nidogens, plays no crucial role in the occurrence and localization of laminin-111, collagen type IV, and perlecan in murine tubular renal basement membranes. | The absence of one or both nidogens does not alter basement membrane composition in adult murine kidney.
Gersdorff N, Otto S, Roediger M, Kruegel J, Miosge N. | 01/21/2010 |