| Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in Caenorhabditis elegans. | Whole genome profiling of short-term hypoxia induced genes and identification of HIF-1 binding sites provide insights into HIF-1 function in Caenorhabditis elegans.
Feng D, Qu L, Powell-Coffman JA., Free PMC Article | 06/3/2024 |
| The rhy-1 gene encodes a predicated O-acyltransferase enzyme that has previously been shown to negatively regulate HIF-1 activity. Our data indicate that RHY-1 has novel, hif-1 independent, function that promotes survival in H2S. | A Novel Mechanism To Prevent H(2)S Toxicity in Caenorhabditis elegans.
Horsman JW, Heinis FI, Miller DL., Free PMC Article | 02/15/2020 |
| The authors discovered that a HIF target, the Caenorhabditis elegans gene cyp-36A1, is required for numerous HIF-dependent processes, including modulation of gene expression, stress resistance, and behavior. | Hypoxia-inducible factor cell non-autonomously regulates C. elegans stress responses and behavior via a nuclear receptor.
Pender CL, Horvitz HR., Free PMC Article | 03/30/2019 |
| Our results suggest that these detoxification pathways are mediated by the hypoxia inducible factor HIF-1. Finally, we show that sulfide resistance varies among wild C. elegans and other nematode species, suggesting that tolerance to sulfide was naturally selected in certain habitats. | Mechanisms of defense against products of cysteine catabolism in the nematode Caenorhabditis elegans.
Livshits L, Chatterjee AK, Karbian N, Abergel R, Abergel Z, Gross E. | 12/16/2017 |
| blocking HIF-1 activity may promote survival in cells with compromised mitochondrial function. | Loss of hif-1 promotes resistance to the exogenous mitochondrial stressor ethidium bromide in Caenorhabditis elegans.
Kamal M, D'Amora DR, Kubiseski TJ., Free PMC Article | 06/3/2017 |
| HIF-1-mediated activation of 5-HT signalling promotes axon regeneration by activating both the RhoA and cAMP pathways. | Axotomy-induced HIF-serotonin signalling axis promotes axon regeneration in C. elegans.
Alam T, Maruyama H, Li C, Pastuhov SI, Nix P, Bastiani M, Hisamoto N, Matsumoto K., Free PMC Article | 06/11/2016 |
| this study reports that neuronal stabilization of HIF-1 mediates these effects in Caenorhabditis elegans through a cell nonautonomous signal to the intestine, which results in activation of the xenobiotic detoxification enzyme flavin-containing monooxygenase-2 (FMO-2). | Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.
Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M., Free PMC Article | 01/16/2016 |
| AMPK and HIF-1 may control immunity and longevity tightly by acting as feedback regulators of ROS | Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans.
Hwang AB, Ryu EA, Artan M, Chang HW, Kabir MH, Nam HJ, Lee D, Yang JS, Kim S, Mair WB, Lee C, Lee SS, Lee SJ., Free PMC Article | 04/25/2015 |
| Growth in hypoxia increases longevity in wild-type worms but not in animals lacking HIF-1 or DAF-16. Conversely, hypoxia shortens life span in combination with overexpression of the antioxidant stress response protein SKN-1. | Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1.
Leiser SF, Fletcher M, Begun A, Kaeberlein M., Free PMC Article | 12/7/2013 |
| HIF can function either as a gene-specific inducer or repressor of host defense, providing a molecular mechanism by which HIF can have apparently opposing roles in defense and inflammation. | EGL-9 controls C. elegans host defense specificity through prolyl hydroxylation-dependent and -independent HIF-1 pathways.
Luhachack LG, Visvikis O, Wollenberg AC, Lacy-Hulbert A, Stuart LM, Irazoqui JE., Free PMC Article | 02/2/2013 |
| Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae. | Increased levels of hydrogen peroxide induce a HIF-1-dependent modification of lipid metabolism in AMPK compromised C. elegans dauer larvae.
Xie M, Roy R. | 01/12/2013 |
| These data show that HIF-1 regulates intestinal iron homeostasis during iron deficiency by activating and inhibiting genes involved in iron uptake and storage. | HIF-1 regulates iron homeostasis in Caenorhabditis elegans by activation and inhibition of genes involved in iron uptake and storage.
Romney SJ, Newman BS, Thacker C, Leibold EA., Free PMC Article | 03/24/2012 |
| Data indicate that genes sqrd-1, ethe-1, cysl-1, cysl-2 and HIF-1 are involved in survival to hydrogen sulfide and hydrogen cyanide. | The response of Caenorhabditis elegans to hydrogen sulfide and hydrogen cyanide.
Budde MW, Roth MB., Free PMC Article | 02/18/2012 |
| Data show that stabilization of HIF-1 increases life span robustly under all conditions tested; however, deletion of hif-1 increases life span in a temperature-dependent manner. | HIF-1 modulates longevity and healthspan in a temperature-dependent manner.
Leiser SF, Begun A, Kaeberlein M., Free PMC Article | 07/9/2011 |
| Data show that that reactive oxygen species (ROS) are increased in respiration mutants and that mild increases in ROS can stimulate HIF-1 to activate gene expression and promote longevity. | Inhibition of respiration extends C. elegans life span via reactive oxygen species that increase HIF-1 activity.
Lee SJ, Hwang AB, Kenyon C., Free PMC Article | 03/19/2011 |
| These data support a model in which SWAN-1, MBK-1 and EGL-9 regulate HIF-1 transcriptional activity and modulate C. elegans resistance to P. aeruginosa PAO1 fast killing. | C. elegans SWAN-1 Binds to EGL-9 and regulates HIF-1-mediated resistance to the bacterial pathogen Pseudomonas aeruginosa PAO1.
Shao Z, Zhang Y, Ye Q, Saldanha JN, Powell-Coffman JA., Free PMC Article | 12/4/2010 |
| transgerminal neuroectodermal conversion of hMSCs into NSC-like cells is accompanied by extensive changes of their global gene expression profile, which might be controlled in part by transcription factor networks related to HIF-1 and miR-124a | Genome-wide expression profiling and functional network analysis upon neuroectodermal conversion of human mesenchymal stem cells suggest HIF-1 and miR-124a as important regulators.
Maisel M, Habisch HJ, Royer L, Herr A, Milosevic J, Hermann A, Liebau S, Brenner R, Schwarz J, Schroeder M, Storch A. | 11/13/2010 |
| The antiapoptotic property of HIF-1 is mediated by means of transcriptional upregulation of the tyrosinase family member TYR-2 in the ASJ sensory neurons | HIF-1 antagonizes p53-mediated apoptosis through a secreted neuronal tyrosinase.
Sendoel A, Kohler I, Fellmann C, Lowe SW, Hengartner MO., Free PMC Article | 07/19/2010 |
| Data show that EGL-9 inhibits HIF-1 transcriptional activity via a pathway that has little or no requirement for hydroxylase activity or for the EGL-9 MYND domain. | Two distinct roles for EGL-9 in the regulation of HIF-1-mediated gene expression in Caenorhabditis elegans.
Shao Z, Zhang Y, Powell-Coffman JA., Free PMC Article | 04/19/2010 |
| C. elegans are protected from lethal hypoxia by an embryonic diapause, and neuronal HIF-1 activity in the adult dictates the O(2) tension at which the diapause is engaged. | C. elegans are protected from lethal hypoxia by an embryonic diapause.
Miller DL, Roth MB., Free PMC Article | 01/21/2010 |
| data establish HIF-1 as one of the key stress-responsive transcription factors that modulate longevity in C. elegans and advance our understanding of the regulatory networks that link oxygen homeostasis and aging | The HIF-1 hypoxia-inducible factor modulates lifespan in C. elegans.
Zhang Y, Shao Z, Zhai Z, Shen C, Powell-Coffman JA., Free PMC Article | 01/21/2010 |
| HIF-1 deficiency results in extended lifespan, which overlaps with that by inhibition of the RSKS-1/S6 kinase, a key component of the TOR pathway. | HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans.
Chen D, Thomas EL, Kapahi P., Free PMC Article | 01/21/2010 |
| loss of VHL-1 increased life span; deletion of HIF-1 was epistatic to VHL-1, indicating HIF-1 acts downstream of VHL-1 to modulate aging; VHL-1 & HIF-1 control longevity by a mechanism distinct from dietary restriction & insulin-like signaling | Proteasomal regulation of the hypoxic response modulates aging in C. elegans.
Mehta R, Steinkraus KA, Sutphin GL, Ramos FJ, Shamieh LS, Huh A, Davis C, Chandler-Brown D, Kaeberlein M., Free PMC Article | 01/21/2010 |
| Data show that the mutants with a reduced progeny production survive long-term anoxia in a daf-16- and hif-1-independent manner. | Reduction in ovulation or male sex phenotype increases long-term anoxia survival in a daf-16-independent manner in Caenorhabditis elegans.
Mendenhall AR, LeBlanc MG, Mohan DP, Padilla PA., Free PMC Article | 01/21/2010 |
| Hypoxia caused specific axon pathfinding and neuronal migration defects in C. elegans that result from the stabilization of the transcription factor HIF-1 (hypoxia-inducible factor 1) in neurons and muscle. | Oxygen levels affect axon guidance and neuronal migration in Caenorhabditis elegans.
Pocock R, Hobert O. | 01/21/2010 |