| TRIM55 promotes noncanonical NF-kappaB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing. | TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing.
Lin L, Yu H, Li L, Yang W, Chen X, Gong Y, Lei Q, Li Z, Zhou Z, Dai L, Zhang H, Hu H. | 11/2/2023 |
| HDAC5-Mediated Acetylation of p100 Suppresses Its Processing. | HDAC5-Mediated Acetylation of p100 Suppresses Its Processing.
Wang J, Wu S, Liu L, Pang Y, Li Z, Mu H., Free PMC Article | 06/23/2023 |
| Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa. | Nfkb2 deficiency and its impact on plasma cells and immunoglobulin expression in murine small intestinal mucosa.
Papoutsopoulou S, Tang J, Elramli AH, Williams JM, Gupta N, Ikuomola FI, Sheibani-Tezerji R, Alam MT, Hernández-Fernaud JR, Caamaño JH, Probert CS, Muller W, Duckworth CA, Pritchard DM., Free PMC Article | 10/1/2022 |
| Trim14 promotes osteoclastogenesis and noncanonical NF-kappaB activation by targeting p100/p52 in chronic periodontitis. | Trim14 promotes osteoclastogenesis and noncanonical NF-κB activation by targeting p100/p52 in chronic periodontitis.
Zhang J, Lin X, Sun Y, Wei J, Wu J. | 10/1/2022 |
| TiO2 nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2. | TiO(2) nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2.
Li S, Yan D, Huang C, Yang F, Cao Y. | 01/29/2022 |
| An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-kappaB module. | An epithelial Nfkb2 pathway exacerbates intestinal inflammation by supplementing latent RelA dimers to the canonical NF-κB module.
Chawla M, Mukherjee T, Deka A, Chatterjee B, Sarkar UA, Singh AK, Kedia S, Lum J, Dhillon MK, Banoth B, Biswas SK, Ahuja V, Basak S., Free PMC Article | 12/4/2021 |
| Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility. | Nfkb2 variants reveal a p100-degradation threshold that defines autoimmune susceptibility.
Wirasinha RC, Davies AR, Srivastava M, Sheridan JM, Sng XYX, Delmonte OM, Dobbs K, Loh KL, Miosge LA, Lee CE, Chand R, Chan A, Yap JY, Keller MD, Chen K, Rossjohn J, La Gruta NL, Vinuesa CG, Reid HH, Lionakis MS, Notarangelo LD, Gray DHD, Goodnow CC, Cook MC, Daley SR., Free PMC Article | 09/11/2021 |
| NF-kappaB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells. | NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells.
Jones LG, Vaida A, Thompson LM, Ikuomola FI, Caamaño JH, Burkitt MD, Miyajima F, Williams JM, Campbell BJ, Pritchard DM, Duckworth CA., Free PMC Article | 09/5/2020 |
| Gene expression and chromatin accessibility analyses of in vivo- and ex vivo-generated LSD1-deficient MZB indicated that LSD1 regulated the downstream target genes of noncanonical NF-kappaB signaling. Additionally LSD1 was found to interact with the noncanonical NF-kappaB transcription factor p52. | LSD1 Cooperates with Noncanonical NF-κB Signaling to Regulate Marginal Zone B Cell Development.
Haines RR, Scharer CD, Lobby JL, Boss JM., Free PMC Article | 05/23/2020 |
| Inactivation of NF-kappaB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction. | Inactivation of NF-κB2 (p52) restrains hepatic glucagon response via preserving PDE4B induction.
Zhang WS, Pan A, Zhang X, Ying A, Ma G, Liu BL, Qi LW, Liu Q, Li P., Free PMC Article | 01/11/2020 |
| The study investigated the impact of non-canonical NF-kappaB signaling on lung carcinogenesis. p52 over-expression led to increased tumor number and progression after injection of the carcinogen urethane in mice. Gene expression analysis of lungs from transgenic mice combined with in vitro studies suggested that p52 promotes proliferation of lung epithelial cells through regulation of cell cycle-associated genes. | p52 expression enhances lung cancer progression.
Saxon JA, Yu H, Polosukhin VV, Stathopoulos GT, Gleaves LA, McLoed AG, Massion PP, Yull FE, Zhao Z, Blackwell TS., Free PMC Article | 10/12/2019 |
| in vivo bioluminescence imaging in a transgenic model of inflammation showed that luciferase activity coincided with endogenous p52/p100 Nfkb2 expression | Tracing the dynamic expression of the Nfκb2 gene during inflammatory processes by in vivo bioluminescence imaging in transgenic mice.
Yang X, Sun R, Ci L, Wang N, Yang S, Shi J, Yang H, Zhang M, Fei J. | 10/13/2018 |
| our studies for the first time establish p100 as a key tumor suppressor of bladder cancer growth | Inhibition of PHLPP2/cyclin D1 protein translation contributes to the tumor suppressive effect of NFκB2 (p100).
Xu J, Wang Y, Hua X, Xu J, Tian Z, Jin H, Li J, Wu XR, Huang C., Free PMC Article | 01/27/2018 |
| hyperresponsive promoter engaged the RelA:p52 dimer generated during costimulation of macrophages through TLR4 and LTbetaR to trigger synthesis of IkappaBalpha at late time points, which prevented the late-acting RelA cross-talk response. | Late-phase synthesis of IκBα insulates the TLR4-activated canonical NF-κB pathway from noncanonical NF-κB signaling in macrophages.
Chatterjee B, Banoth B, Mukherjee T, Taye N, Vijayaragavan B, Chattopadhyay S, Gomes J, Basak S., Free PMC Article | 11/26/2017 |
| results suggest that changes in the relative concentrations of RelB, NIK:IKK1, and p100 during noncanonical signaling modulate this transitional complex and are critical for maintaining the fine balance between the processing and protection of p100. | The NF-κB subunit RelB controls p100 processing by competing with the kinases NIK and IKK1 for binding to p100.
Fusco AJ, Mazumder A, Wang VY, Tao Z, Ware C, Ghosh G. | 11/25/2017 |
| Results suggest that the RelB/NF-kappaB2 pathway regulates T cell migration to autoimmune targets in Sjogren syndrome through TGFbeta/TGFbetaR-dependent regulation of CXCL12/CXCR4 signaling. | NF-κB2 Controls the Migratory Activity of Memory T Cells by Regulating Expression of CXCR4 in a Mouse Model of Sjögren's Syndrome.
Kurosawa M, Arakaki R, Yamada A, Tsunematsu T, Kudo Y, Sprent J, Ishimaru N. | 11/11/2017 |
| MKK4 activates non-canonical NFkappaB signaling by promoting NFkappaB2-p100 processing. | MKK4 activates non-canonical NFκB signaling by promoting NFκB2-p100 processing.
Kim JS, Kim EJ, Kim HS, Kurie JM, Ahn YH. | 08/26/2017 |
| the aberrant proliferative capacity of Brca1(-/-) luminal progenitor cells is linked to the replication-associated DNA damage response, where proliferation of mammary progenitors is perpetuated by damage-induced, autologous NF-kappaB signaling. | Persistent Activation of NF-κB in BRCA1-Deficient Mammary Progenitors Drives Aberrant Proliferation and Accumulation of DNA Damage.
Sau A, Lau R, Cabrita MA, Nolan E, Crooks PA, Visvader JE, Pratt MA., Free PMC Article | 07/22/2017 |
| RelB is processed by CO2 in a manner dependent on a key C-terminal domain located in its transactivation domain. Loss of the RelB transactivation domain alters NF-kappaB-dependent transcriptional activity, and loss of p100 alters sensitivity of RelB to CO2 | Carbon dioxide-dependent regulation of NF-κB family members RelB and p100 gives molecular insight into CO(2)-dependent immune regulation.
Keogh CE, Scholz CC, Rodriguez J, Selfridge AC, von Kriegsheim A, Cummins EP., Free PMC Article | 07/15/2017 |
| the individual functions of the NF-kappaB family members NF-kappaB1, NF-kappaB2 and c-REL in the various autoimmune pathologies of Fas(lpr/lpr) mutant mice, were investigated. | Impact of loss of NF-κB1, NF-κB2 or c-REL on SLE-like autoimmune disease and lymphadenopathy in Fas(lpr/lpr) mutant mice.
Low JT, Hughes P, Lin A, Siebenlist U, Jain R, Yaprianto K, Gray DH, Gerondakis S, Strasser A, O'Reilly LA. | 10/1/2016 |
| we identify in this study a critical role for the combined activity of the RELB and NF-kappaB2 subunits in B cell homeostasis that cannot be compensated for by the canonical NF-kappaB pathway under physiological conditions. | Impairment of Mature B Cell Maintenance upon Combined Deletion of the Alternative NF-κB Transcription Factors RELB and NF-κB2 in B Cells.
De Silva NS, Silva K, Anderson MM, Bhagat G, Klein U., Free PMC Article | 08/13/2016 |
| Mechanistically the LncRNA-HIT siRNA treatments impacted pro-chondrogenic gene expression by reducing H3K27ac or p100 activity, confirming that LncRNA-HIT is essential for chondrogenic differentiation in the limb mesenchyme | LncRNA-HIT Functions as an Epigenetic Regulator of Chondrogenesis through Its Recruitment of p100/CBP Complexes.
Carlson HL, Quinn JJ, Yang YW, Thornburg CK, Chang HY, Stadler HS., Free PMC Article | 06/11/2016 |
| Nfkb2 connected lymphotoxin signal within the intestinal niche in reinforcing epithelial innate inflammatory RelA/NF-kappaB response to Citrobacter rodentium infection, while Nfkb2(-/-) mice succumbed to gut infections owing to stromal defects. | Stimulus-selective crosstalk via the NF-κB signaling system reinforces innate immune response to alleviate gut infection.
Banoth B, Chatterjee B, Vijayaragavan B, Prasad MV, Roy P, Basak S., Free PMC Article | 01/30/2016 |
| Data indicate a coupled increase in the expression of renal, relA, NF-kB2, and p53 genes and proteins during folic acid induced acute kidney injury (AKI). | The restrained expression of NF-kB in renal tissue ameliorates folic acid induced acute kidney injury in mice.
Kumar D, Singla SK, Puri V, Puri S., Free PMC Article | 01/30/2016 |
| Loss of c-REL but not NF-kappaB2 prevents autoimmune disease driven by FasL mutation. | Loss of c-REL but not NF-κB2 prevents autoimmune disease driven by FasL mutation.
O'Reilly LA, Hughes P, Lin A, Waring P, Siebenlist U, Jain R, Gray DH, Gerondakis S, Strasser A., Free PMC Article | 12/26/2015 |