| Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx. | Genetic deficiency of the transcription factor NFAT1 confers protection against fibrogenic responses independent of immune influx.
Vittal R, Walker NM, McLinden AP, Braeuer RR, Ke F, Fattahi F, Combs MP, Misumi K, Aoki Y, Wheeler DS, Wilke CA, Huang SK, Moore BB, Cao P, Lama VN., | 01/7/2024 |
| NFAT1 and NFkappaB regulates expression of the common gamma-chain cytokine receptor in activated T cells. | NFAT1 and NFκB regulates expression of the common γ-chain cytokine receptor in activated T cells.
Shim JA, Lee SM, Jeong JW, Kim H, Son WJ, Park JH, Song P, Im SH, Bae S, Park JH, Jo Y, Hong C., Free PMC Article | 11/3/2023 |
| Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation. | Glycogen synthase kinase 3 controls T-cell exhaustion by regulating NFAT activation.
Fu Y, Wang J, Liu C, Liao K, Gao X, Tang R, Fan B, Hong Y, Xiao N, Xiao C, Liu WH., Free PMC Article | 10/5/2023 |
| WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway. | WNT16b promotes the proliferation and self-renewal of human limbal epithelial stem/progenitor cells via activating the calcium/calcineurin A/NFATC2 pathway.
Wan X, Zhao S, Dai Y, Zhang J, Shen Y, Gong L, Le Q., Free PMC Article | 10/4/2023 |
| Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation. | Macrophage P2Y6 Receptor Signaling Selectively Activates NFATC2 and Suppresses Allergic Lung Inflammation.
Nagai J, Lin J, Boyce JA., Free PMC Article | 12/17/2022 |
| Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice. | Genetic inhibition of nuclear factor of activated T-cell c2 prevents atrial fibrillation in CREM transgenic mice.
Ni L, Lahiri SK, Nie J, Pan X, Abu-Taha I, Reynolds JO, Campbell HM, Wang H, Kamler M, Schmitz W, Müller FU, Li N, Wei X, Wang DW, Dobrev D, Wehrens XHT., Free PMC Article | 10/29/2022 |
| Thalidomide attenuates oral epithelial cell apoptosis and pro-inflammatory cytokines secretion induced by radiotherapy via the miR-9-3p/NFATC2/NF-kappaB axis. | Thalidomide attenuates oral epithelial cell apoptosis and pro-inflammatory cytokines secretion induced by radiotherapy via the miR-9-3p/NFATC2/NF-κB axis.
Liang L, Chen L, Liu G, Jiang L, Que L, Chen J, Wang R, Zhu H. | 05/7/2022 |
| Identification of direct transcriptional targets of NFATC2 that promote beta cell proliferation. | Identification of direct transcriptional targets of NFATC2 that promote β cell proliferation.
Simonett SP, Shin S, Herring JA, Bacher R, Smith LA, Dong C, Rabaglia ME, Stapleton DS, Schueler KL, Choi J, Bernstein MN, Turkewitz DR, Perez-Cervantes C, Spaeth J, Stein R, Tessem JS, Kendziorski C, Keleş S, Moskowitz IP, Keller MP, Attie AD., Free PMC Article | 12/11/2021 |
| Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription. | Nitric oxide attenuates microglia proliferation by sequentially facilitating calcium influx through TRPV2 channels, activating NFATC2, and increasing p21 transcription.
Maksoud MJE, Tellios V, Lu WY., Free PMC Article | 12/4/2021 |
| Rapid and Efficient Gene Editing for Direct Transplantation of Naive Murine Cas9(+) T Cells. | Rapid and Efficient Gene Editing for Direct Transplantation of Naive Murine Cas9(+) T Cells.
Majumder S, Jugovic I, Saul D, Bell L, Hundhausen N, Seal R, Beilhack A, Rosenwald A, Mougiakakos D, Berberich-Siebelt F., Free PMC Article | 10/30/2021 |
| Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway. | Testicular Lmcd1 regulates phagocytosis by Sertoli cells through modulation of NFAT1/Txlna signaling pathway.
Jin X, Zhang S, Ding T, Zhao P, Zhang C, Zhang Y, Li W., Free PMC Article | 08/28/2021 |
| LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies. | LRRK2 mediates microglial neurotoxicity via NFATc2 in rodent models of synucleinopathies.
Kim C, Beilina A, Smith N, Li Y, Kim M, Kumaran R, Kaganovich A, Mamais A, Adame A, Iba M, Kwon S, Lee WJ, Shin SJ, Rissman RA, You S, Lee SJ, Singleton AB, Cookson MR, Masliah E., Free PMC Article | 08/14/2021 |
| Genetic inhibition of NFATC2 attenuates asparaginase hypersensitivity in mice. | Genetic inhibition of NFATC2 attenuates asparaginase hypersensitivity in mice.
Rathod S, Ramsey M, Finkelman FD, Fernandez CA., Free PMC Article | 07/10/2021 |
| In Activated Murine Mast Cells, NFATc2 Is Critical for the Production of Autocrine IL-3, Thereby Promoting the Expression of IL-9. | In Activated Murine Mast Cells, NFATc2 Is Critical for the Production of Autocrine IL-3, Thereby Promoting the Expression of IL-9.
Sabbaghi F, Ullner L, Bohn T, Hahlbrock J, Bopp T, Schmitt E, Klein M, Stassen M. | 05/22/2021 |
| All-trans-retinoic acid shifts Th1 towards Th2 cell differentiation by targeting NFAT1 signalling to ameliorate immune-mediated aplastic anaemia. | All-trans-retinoic acid shifts Th1 towards Th2 cell differentiation by targeting NFAT1 signalling to ameliorate immune-mediated aplastic anaemia.
Tang D, Liu S, Sun H, Qin X, Zhou N, Zheng W, Zhang M, Zhou H, Tuersunayi A, Duan C, Chen J. | 03/27/2021 |
| Augmented O-GlcNAcylation attenuates intermittent hypoxia-induced cardiac remodeling through the suppression of NFAT and NF-kappaB activities in mice. | Augmented O-GlcNAcylation attenuates intermittent hypoxia-induced cardiac remodeling through the suppression of NFAT and NF-κB activities in mice.
Nakagawa T, Furukawa Y, Hayashi T, Nomura A, Yokoe S, Moriwaki K, Kato R, Ijiri Y, Yamaguchi T, Izumi Y, Yoshiyama M, Asahi M. | 11/21/2020 |
| Our results suggest that NFAT1 and NFAT2 have distinct roles in mediating CD8(+) T cell differentiation and function | NFAT1 and NFAT2 Differentially Regulate CTL Differentiation Upon Acute Viral Infection.
Xu T, Keller A, Martinez GJ., Free PMC Article | 01/18/2020 |
| These findings have provided underlying molecular details for the aggressive behavior of basal-like breast cancer (BLBC). The Snail-mediated downregulation of ABAT expression in BLBC provides tumorigenic and metastatic advantages by activating GABA-mediated Ca(2+)-NFAT1 axis. | Loss of ABAT-Mediated GABAergic System Promotes Basal-Like Breast Cancer Progression by Activating Ca(2+)-NFAT1 Axis.
Chen X, Cao Q, Liao R, Wu X, Xun S, Huang J, Dong C., Free PMC Article | 12/7/2019 |
| NFATc2 is necessary for optimal osteoclastogenesis in vitro, but its downregulation in the myeloid lineage has no consequences in skeletal remodeling in vivo. | Nuclear factor of activated T cells 2 is required for osteoclast differentiation and function in vitro but not in vivo.
Yu J, Zanotti S, Schilling L, Canalis E., Free PMC Article | 10/12/2019 |
| NFATc2 isoform was the most highly expressed in murine microglia cultures, and inhibition or deletion of NFATc2 was sufficient to attenuate the ability of the microglia to secrete cytokines. AbetaPP/PS1 (Alzheimer's disease model) x NFATc2-/- mice had attenuated cytokine levels compared to AbetaPP/PS1 mice as well as reduced microgliosis and astrogliosis with no effect on plaque load. | NFATc2 Modulates Microglial Activation in the AβPP/PS1 Mouse Model of Alzheimer's Disease.
Manocha GD, Ghatak A, Puig KL, Kraner SD, Norris CM, Combs CK., Free PMC Article | 03/24/2018 |
| data suggest that NFAT1 may limit the hyperactivation of the NF-kappaB-mediated proinflammatory response in DCs and suppress autoimmunity by serving as a key regulator of DC tolerance. | NFAT1 Regulates Systemic Autoimmunity through the Modulation of a Dendritic Cell Property.
Chae CS, Kim GC, Park ES, Lee CG, Verma R, Cho HL, Jun CD, Yoo YJ, Im SH. | 10/28/2017 |
| These results support the idea that NFAT1 is necessary to fully suppress effector responses during Plasmodium-induced CD4(+) T cell exhaustion. | The Transcription Factor NFAT1 Participates in the Induction of CD4(+) T Cell Functional Exhaustion during Plasmodium yoelii Infection.
Ames RY, Ting LM, Gendlina I, Kim K, Macian F., Free PMC Article | 09/9/2017 |
| These results demonstrate a repressor role for NFAT1 in cell cycle progression and Cyclin E expression in B lymphocytes, and suggest a potential function for NFAT1 protein in B cell malignancies. | NFAT1 transcription factor regulates cell cycle progression and cyclin E expression in B lymphocytes.
Teixeira LK, Carrossini N, Sécca C, Kroll JE, DaCunha DC, Faget DV, Carvalho LD, de Souza SJ, Viola JP., Free PMC Article | 06/24/2017 |
| Overexpression of either ca-Nfatc2 or ca-Nfatc1 in mouse islets enhanced insulin secretion, whereas only ca-Nfatc2 was able to promote b-cell proliferation, suggesting distinct molecular pathways mediating insulin secretion vs. b-cell proliferation are regulated by NFAT | The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.
Keller MP, Paul PK, Rabaglia ME, Stapleton DS, Schueler KL, Broman AT, Ye SI, Leng N, Brandon CJ, Neto EC, Plaisier CL, Simonett SP, Kebede MA, Sheynkman GM, Klein MA, Baliga NS, Smith LM, Broman KW, Yandell BS, Kendziorski C, Attie AD., Free PMC Article | 05/13/2017 |
| our results suggest the NFAT1 plays a pivotal role as a genetic switch in CD4(+)/CD8(+) T cell tolerance by regulating AICD process in the T cell mediated skin inflammation. | Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.
Kwon HK, Kim GC, Hwang JS, Kim Y, Chae CS, Nam JH, Jun CD, Rudra D, Surh CD, Im SH., Free PMC Article | 12/31/2016 |