| V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans. | V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans.
Li TY, Gao AW, Li X, Li H, Liu YJ, Lalou A, Neelagandan N, Naef F, Schoonjans K, Auwerx J., Free PMC Article | 11/5/2022 |
| The UPRmt preserves mitochondrial import to extend lifespan. | The UPRmt preserves mitochondrial import to extend lifespan.
Xin N, Durieux J, Yang C, Wolff S, Kim HE, Dillin A., Free PMC Article | 05/28/2022 |
| Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors. | Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors.
Soo SK, Traa A, Rudich PD, Mistry M, Van Raamsdonk JM., Free PMC Article | 03/26/2022 |
| FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation. | FNDC-1-mediated mitophagy and ATFS-1 coordinate to protect against hypoxia-reoxygenation.
Lim Y, Berry B, Viteri S, McCall M, Park EC, Rongo C, Brookes PS, Nehrke K., Free PMC Article | 03/26/2022 |
| LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria. | LONP-1 and ATFS-1 sustain deleterious heteroplasmy by promoting mtDNA replication in dysfunctional mitochondria.
Yang Q, Liu P, Anderson NS, Shpilka T, Du Y, Naresh NU, Li R, Zhu LJ, Luk K, Lavelle J, Zeinert RD, Chien P, Wolfe SA, Haynes CM., Free PMC Article | 03/5/2022 |
| Caenorhabditis elegans homologue of Fam210 is required for oogenesis and reproduction. | Caenorhabditis elegans homologue of Fam210 is required for oogenesis and reproduction.
Kang J, Zhou H, Sun F, Chen Y, Zhao J, Yang WJ, Xu S, Chen C. | 08/7/2021 |
| ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress. | ATP13A2-mediated endo-lysosomal polyamine export counters mitochondrial oxidative stress.
Vrijsen S, Besora-Casals L, van Veen S, Zielich J, Van den Haute C, Hamouda NN, Fischer C, Ghesquière B, Tournev I, Agostinis P, Baekelandt V, Eggermont J, Lambie E, Martin S, Vangheluwe P., Free PMC Article | 02/2/2021 |
| While loss of atfs-1 during adulthood does not affect lifespan in any of these strains, absence of atfs-1 during development prevents clk-1 and isp-1 worms from reaching adulthood and reduces the lifespan of nuo-6 mutants. | Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.
Wu Z, Senchuk MM, Dues DJ, Johnson BK, Cooper JF, Lew L, Machiela E, Schaar CE, DeJonge H, Blackwell TK, Van Raamsdonk JM., Free PMC Article | 05/4/2019 |
| Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the mitochondrial unfolded protein response. | Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPR(mt).
Nargund AM, Fiorese CJ, Pellegrino MW, Deng P, Haynes CM., Free PMC Article | 06/20/2015 |
| The bZip transcription factor ATFS-1 mediates mitochondrial stress-induced autophagy. | Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development.
Guo B, Huang X, Zhang P, Qi L, Liang Q, Zhang X, Huang J, Fang B, Hou W, Han J, Zhang H., Free PMC Article | 01/17/2015 |
| ATFS-1 has a role in protecting cells from inhibition of the mevalonate pathway | The mitochondrial unfolded protein response activator ATFS-1 protects cells from inhibition of the mevalonate pathway.
Rauthan M, Ranji P, Aguilera Pradenas N, Pitot C, Pilon M., Free PMC Article | 07/13/2013 |
| these results show that cells monitor mitochondrial import efficiency via ATFS-1 to coordinate the level of mitochondrial dysfunction with the protective transcriptional response. | Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation.
Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM., Free PMC Article | 09/15/2012 |
| Defective UPR(mt) signaling in the haf-1-deleted worms was associated with failure of the bZIP protein, ZC376.7, to localize to nuclei in worms with perturbed mitochondrial protein folding. | The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans.
Haynes CM, Yang Y, Blais SP, Neubert TA, Ron D., Free PMC Article | 03/29/2010 |