| Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development. | Distinct Requirements for Adaptor Proteins NCK1 and NCK2 in Mammary Gland Development.
Golding AP, Ferrier B, New LA, Lu P, Martin CE, Shata E, Jones RA, Moorehead RA, Jones N., Free PMC Article | 07/24/2023 |
| NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation. | NCK1 Modulates Neuronal Actin Dynamics and Promotes Dendritic Spine, Synapse, and Memory Formation.
Diab AM, Wigerius M, Quinn DP, Qi J, Shahin I, Paffile J, Krueger K, Karten B, Krueger SR, Fawcett JP., Free PMC Article | 02/15/2023 |
| Activation of the PDGFRalpha-Nrf2 pathway mediates impaired adipocyte differentiation in bone marrow mesenchymal stem cells lacking Nck1. | Activation of the PDGFRα-Nrf2 pathway mediates impaired adipocyte differentiation in bone marrow mesenchymal stem cells lacking Nck1.
Haider N, Larose L., Free PMC Article | 07/10/2021 |
| Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability. | Nck1, But Not Nck2, Mediates Disturbed Flow-Induced p21-Activated Kinase Activation and Endothelial Permeability.
Alfaidi M, Bhattarai U, Orr AW., Free PMC Article | 03/13/2021 |
| Selective role of Nck1 in atherogenic inflammation and plaque formation. | Selective role of Nck1 in atherogenic inflammation and plaque formation.
Alfaidi M, Acosta CH, Wang D, Traylor JG, Orr AW., Free PMC Article | 02/6/2021 |
| SHIP interacts with adaptor protein Nck and restricts actin turnover in B cells. | SHIP interacts with adaptor protein Nck and restricts actin turnover in B cells.
Pauls SD, Hou S, Marshall AJ. | 12/26/2020 |
| Nck1 silencing in pancreatic beta cells promotes PERK activation and signaling to protect beta cells against pathological stresses. | Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling.
Yamani L, Li B, Larose L. | 09/24/2016 |
| In mice with Nck1/2 deletions, endothelial cells fail to develop front-rear polarized vessel sprouts. | Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.
Dubrac A, Genet G, Ola R, Zhang F, Pibouin-Fragner L, Han J, Zhang J, Thomas JL, Chedotal A, Schwartz MA, Eichmann A., Free PMC Article | 06/28/2016 |
| These results reveal that Nck regulates preosteoblastic/osteoblastic migration and bone mass. | Nck influences preosteoblastic/osteoblastic migration and bone mass.
Aryal A C S, Miyai K, Izu Y, Hayata T, Notomi T, Noda M, Ezura Y., Free PMC Article | 05/14/2016 |
| we show that the non-catalytic region of tyrosine kinase adaptor (NCK) proteins 1 and 2 are distributed in the developing spinal cord | NCK is critical for the development of deleted in colorectal cancer (DCC) sensitive spinal circuits.
Lane C, Qi J, Fawcett JP. | 12/19/2015 |
| Nck proteins not only participate in thymic selection and generation of the peripheral T cell repertoire but also are involved in the differentiation and effector functions of CD4(+) T cells. | Nck adaptor proteins modulate differentiation and effector function of T cells.
Lu KH, Keppler S, Leithäuser F, Mattfeldt T, Castello A, Kostezka U, Küblbeck G, Schmitt S, Klevenz A, Prokosch S, Pougialis G, Pawson T, Batista F, Tafuri A, Arnold B. | 11/28/2015 |
| these data identify Nck as an important mediator of oxidative stress-induced inflammation and a potential therapeutic target for ischemia/reperfusion injury. | Recruitment of the adaptor protein Nck to PECAM-1 couples oxidative stress to canonical NF-κB signaling and inflammation.
Chen J, Leskov IL, Yurdagul A Jr, Thiel B, Kevil CG, Stokes KY, Orr AW., Free PMC Article | 11/21/2015 |
| Nck may function as an effector of T-cell receptor conformational changes during T cell development. | Conformational changes in the T cell receptor differentially determine T cell subset development in mice.
Blanco R, Borroto A, Schamel W, Pereira P, Alarcon B. | 07/25/2015 |
| Mouse embryos lacking endothelial Nck1/2 expression develop extensive angiogenic defects that result in lethality at about embryonic day 10. | Requisite role for Nck adaptors in cardiovascular development, endothelial-to-mesenchymal transition, and directed cell migration.
Clouthier DL, Harris CN, Harris RA, Martin CE, Puri MC, Jones N., Free PMC Article | 07/4/2015 |
| Nck1 negatively regulates PERK by interacting with PERK and protecting PERK from being dephosphorylated at its inhibitory site pY(561) and in this way affects pancreatic beta-cell proinsulin biogenesis. | Interaction of Nck1 and PERK phosphorylated at Y⁵⁶¹ negatively modulates PERK activity and PERK regulation of pancreatic β-cell proinsulin content.
Yamani L, Latreille M, Larose L., Free PMC Article | 11/29/2014 |
| that Nck recruitment to the TCR is fundamental to mount an efficient T cell response in vivo, and that the Nck-CD3epsilon interaction may represent a target for pharmacological modulation of the immune response. | Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.
Borroto A, Arellano I, Blanco R, Fuentes M, Orfao A, Dopfer EP, Prouza M, Suchànek M, Schamel WW, Alarcón B. | 04/19/2014 |
| Using mouse embryonic fibroblasts lacking Nck, WIP, or N-WASP, this study investigated whether an interaction of Nck with both WIP and N-WASP is required for their recruitment to vaccinia during Arp2/3-dependent actin assembly. | WIP provides an essential link between Nck and N-WASP during Arp2/3-dependent actin polymerization.
Donnelly SK, Weisswange I, Zettl M, Way M., Free PMC Article | 01/18/2014 |
| Nck1 gene deficiency accelerates mechanical unloading-induced bone loss, suggesting Nck1 to be a crucial molecule in mechanical stress mediated regulation in bone metabolism. | Nck1 deficiency accelerates unloading-induced bone loss.
Aryal AC, Miyai K, Hayata T, Notomi T, Nakamoto T, Pawson T, Ezura Y, Noda M. | 11/16/2013 |
| Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. | Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells.
Castello A, Gaya M, Tucholski J, Oellerich T, Lu KH, Tafuri A, Pawson T, Wienands J, Engelke M, Batista FD. | 11/2/2013 |
| The study identifies Nck as a key coordinator of cytoskeletal changes that enable cell polarization and directional migration, which are crucial processes in development and disease. | Nck enables directional cell migration through the coordination of polarized membrane protrusion with adhesion dynamics.
Chaki SP, Barhoumi R, Berginski ME, Sreenivasappa H, Trache A, Gomez SM, Rivera GM. | 11/2/2013 |
| Nck is recruited to the TCR in an inducible manner in CD4+/CD8+ thymocytes. This recruitment is required for the activation of early TCR-dependent events. | Nck recruitment to the TCR required for ZAP70 activation during thymic development.
Borroto A, Arellano I, Dopfer EP, Prouza M, Suchànek M, Fuentes M, Orfao A, Schamel WW, Alarcón B., Free PMC Article | 03/30/2013 |
| These data highlight similar pathogenic strategies shared by EPEC and vaccinia virus by demonstrating a requirement for both Nck and N-WASP, but not WIP or WIP family members in pathogen-induced actin assembly. | Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly.
Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB., Free PMC Article | 02/9/2013 |
| Nck and Cdc42 co-operate to recruit N-WASP to promote FcgammaR-mediated phagocytosis. | Nck and Cdc42 co-operate to recruit N-WASP to promote FcγR-mediated phagocytosis.
Dart AE, Donnelly SK, Holden DW, Way M, Caron E. | 01/26/2013 |
| our findings implicate Nck1 in regulating the unfolded protein response, which secondary to obesity impairs glucose homeostasis and insulin actions | Deletion of Nck1 attenuates hepatic ER stress signaling and improves glucose tolerance and insulin signaling in liver of obese mice.
Latreille M, Laberge MK, Bourret G, Yamani L, Larose L. | 04/23/2011 |
| Fine tuning of the threshold of T cell selection by the Nck adapters. | Fine tuning of the threshold of T cell selection by the Nck adapters.
Roy E, Togbe D, Holdorf A, Trubetskoy D, Nabti S, Küblbeck G, Schmitt S, Kopp-Schneider A, Leithäuser F, Möller P, Bladt F, Hämmerling GJ, Arnold B, Pawson T, Tafuri A. | 01/8/2011 |