| DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis. | DNA methylation-mediated differential expression of DLX4 isoforms has opposing roles in leukemogenesis.
Zhou JD, Zhao YJ, Leng JY, Gu Y, Xu ZJ, Ma JC, Wen XM, Lin J, Zhang TJ, Qian J., Free PMC Article | 07/30/2022 |
| Homeodomain protein DLX4 facilitates nasopharyngeal carcinoma progression via up-regulation of YB-1. | Homeodomain protein DLX4 facilitates nasopharyngeal carcinoma progression via up-regulation of YB-1.
Ling Z, Long X, Li J, Feng M. | 11/21/2020 |
| indicated the hypothesis that DLX4 variants contributing to nonsyndromic orofacial cleft risk should be interpreted with caution | Association Between DLX4 Polymorphisms and Nonsyndromic Orofacial Clefts in a Chinese Han Population.
He M, Bian Z. | 01/18/2020 |
| the role of BP1 protein in tumorigenesis of breast cancer and four other malignancies | BP1, a potential biomarker for breast cancer prognosis.
Lou Y, Fallah Y, Yamane K, Berg PE. | 07/27/2019 |
| Results demonstrate that high expression of BP1 is associated with poor prognosis in patients with endometrial cancer and promotes cell proliferation and migration. | Overexpression of BP1, an isoform of Homeobox Gene DLX4, promotes cell proliferation, migration and predicts poor prognosis in endometrial cancer.
Zhang L, Wan Y, Jiang Y, Zhang Z, Shu S, Cheng W, Lang J. | 06/29/2019 |
| Beta protein 1 (BP1) binds to and regulates estrogen receptor. | Beta protein 1 homeoprotein induces cell growth and estrogen-independent tumorigenesis by binding to the estrogen receptor in breast cancer.
Fu SW, Kirolikar SP, Ginsburg E, Tan X, Schwartz A, Simmens SJ, Man YG, Pinzone JJ, Teal C, Awate S, Vonderhaar BK, Berg PE., Free PMC Article | 02/3/2018 |
| study indicated that DLX4 hypermethylation was a frequent event and acted as an independent prognostic biomarker in de novo myelodysplastic syndrome patients | Hypermethylation of DLX4 predicts poor clinical outcome in patients with myelodysplastic syndrome.
Zhang TJ, Zhou JD, Yang DQ, Wang YX, Yao DM, Ma JC, Wen XM, Guo H, Lin J, Qian J. | 02/18/2017 |
| Our study reveals that BP1 overexpression serves as an independent risk factor in de novo AML patients. | BP1 overexpression is associated with adverse prognosis in de novo acute myeloid leukemia.
Zhou JD, Yang J, Guo H, Deng ZQ, Wen XM, Yang L, Yin JY, Xiao GF, Lin J, Qian J. | 12/17/2016 |
| Collectively, our findings indicate that DLX4 exerts opposing effects on the megakaryocytic and erythroid lineages in part by inducing IL-1beta and NF-kappaB signaling. | The homeobox gene DLX4 regulates erythro-megakaryocytic differentiation by stimulating IL-1β and NF-κB signaling.
Trinh BQ, Barengo N, Kim SB, Lee JS, Zweidler-McKay PA, Naora H., Free PMC Article | 06/4/2016 |
| DLX4 induces CD44 by stimulating IL-1beta-mediated NF-kappaB activity, thereby promoting peritoneal metastasis of ovarian cancer | The homeoprotein DLX4 stimulates NF-κB activation and CD44-mediated tumor-mesothelial cell interactions in ovarian cancer.
Haria D, Trinh BQ, Ko SY, Barengo N, Liu J, Naora H., Free PMC Article | 05/28/2016 |
| This first finding of a DLX4 mutation in a family with Cleft lip and/or palate establishes DLX4 as a potential cause of human clefts | DLX4 is associated with orofacial clefting and abnormal jaw development.
Wu D, Mandal S, Choi A, Anderson A, Prochazkova M, Perry H, Gil-Da-Silva-Lopes VL, Lao R, Wan E, Tang PL, Kwok PY, Klein O, Zhuan B, Slavotinek AM., Free PMC Article | 05/21/2016 |
| DLX4 promotes ovarian tumor angiogenesis in part by stimulating iNOS expression. | The homeoprotein DLX4 controls inducible nitric oxide synthase-mediated angiogenesis in ovarian cancer.
Trinh B, Ko SY, Haria D, Barengo N, Naora H., Free PMC Article | 02/6/2016 |
| Aberrant DNA methylation of the DLX4 and SIM1 genes may be a novel progression marker for uterine cervical low-grade squamous intraepithelial lesions. | Aberrant DNA methylation of DLX4 and SIM1 is a predictive marker for disease progression of uterine cervical low-grade squamous intraepithelial lesion.
Sakane J, Taniyama K, Miyamoto K, Saito A, Kuraoka K, Nishimura T, Sentani K, Oue N, Yasui W. | 01/30/2016 |
| indicate that gains of DLX4 and ERBB2 occur in South African breast cancer patients irrespectively of their race and factors known to influence prognosis | Copy Number Analysis of the DLX4 and ERBB2 Genes in South African Breast Cancer Patients.
Langa BC, Oliveira MM, Pereira SR, Lupicki K, Marian C, Govender D, Panieri E, Hiss D, Cavalli IJ, Abdul-Rasool S, Cavalli LR. | 01/23/2016 |
| a DLX4 overexpression vector lacking the 3'UTR was shown to abolish miR-122-induced inhibition of proliferation in the HCC cell line Hep3B. | Regulation of the oncogenic function of distal-less 4 by microRNA-122 in hepatocellular carcinoma.
Xie XH, Xu XP, Sun CY, Yu ZJ. | 01/16/2016 |
| DLX4 can functionally replace c-MYC. | The homeobox gene DLX4 promotes generation of human induced pluripotent stem cells.
Tamaoki N, Takahashi K, Aoki H, Iida K, Kawaguchi T, Hatakeyama D, Inden M, Chosa N, Ishisaki A, Kunisada T, Shibata T, Goshima N, Yamanaka S, Tezuka K., Free PMC Article | 10/10/2015 |
| Methylated DLX4 is a potential biomarker that predicts poor prognosis after curative resection of pathologic stage I Non-Small Cell Lung Cancer. | Methylated DLX4 Predicts Response to Pathologic Stage I Non-Small Cell Lung Cancer Resection.
Harada H, Miyamoto K, Yamashita Y, Taniyama K, Ohdan H, Okada M. | 08/8/2015 |
| DLX4 increased copy number was observed in 21.6% of the primary breast tumors and 24.3% of the sentinel lymph node metastasis | Increased copy number of the DLX4 homeobox gene in breast axillary lymph node metastasis.
Torresan C, Oliveira MM, Pereira SR, Ribeiro EM, Marian C, Gusev Y, Lima RS, Urban CA, Berg PE, Haddad BR, Cavalli IJ, Cavalli LR., Free PMC Article | 10/11/2014 |
| The results suggest that high expression of DLX4 predicts hepatocellular carcinoma prognosis. | DLX4 as a prognostic marker for hepatocellular carcinoma.
Gao Y, Li Z, Guo X, Liu Y, Zhang K. | 09/27/2014 |
| All trans retinoic acid can inhibit the proliferation and the expression of BP1 in breast cancer cells. | [Effects of all trans retinoic acid on the expression alterations of beta-protein 1 in human breast cancer cell lines of MDA-MB-468 and MCF-7].
Su J, Li MQ, Zhong GS. | 09/7/2013 |
| DLX4 induces cancer cells to undergo epithelial to mesenchymal transition through TWIST, enhancing tumor migration, invasion and metastasis. | DLX4 upregulates TWIST and enhances tumor migration, invasion and metastasis.
Zhang L, Yang M, Gan L, He T, Xiao X, Stewart MD, Liu X, Yang L, Zhang T, Zhao Y, Fu J., Free PMC Article | 02/9/2013 |
| findings suggest that decreased expression of homeobox protein DLX-4 leads to the pathogenesis of preeclampsia by inhibiting epithelial-mesenchymal transition in trophoblasts | Regulation of epithelial-mesenchymal transition by homeobox gene DLX4 in JEG-3 trophoblast cells: a role in preeclampsia.
Sun YY, Lu M, Xi XW, Qiao QQ, Chen LL, Xu XM, Feng YJ. | 02/11/2012 |
| The ability of DLX4 to counteract key transcriptional control mechanisms of the TGF-beta cytostatic program could explain, in part, the resistance of tumors to the antiproliferative effect of TGF-beta. | Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-β cytostatic program and blocks the antiproliferative effect of TGF-β.
Trinh BQ, Barengo N, Naora H., Free PMC Article | 08/27/2011 |
| High BP1 expression is associated with inflammatory breast cancer and tumor aggressiveness | BP1, a putative signature marker for inflammatory breast cancer and tumor aggressiveness.
Man YG, Schwartz A, Levine PH, Teal C, Berg PE. | 01/21/2010 |
| BP1 is an important upstream factor in the carcinogenic pathway of prostate cancer and that the expression of BP1 may reflect or directly contribute to tumor progression and/or invasion. | BP1, a homeoprotein, is significantly expressed in prostate adenocarcinoma and is concordant with prostatic intraepithelial neoplasia.
Schwartz AM, Man YG, Rezaei MK, Simmens SJ, Berg PE. | 01/21/2010 |