| COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells. | COP9 signalosome component CSN-5 stabilizes PUF proteins FBF-1 and FBF-2 in Caenorhabditis elegans germline stem and progenitor cells.
Osterli E, Ellenbecker M, Wang X, Terzo M, Jacobson K, Cuello D, Voronina E., | 06/3/2024 |
| Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2. | Antagonistic control of Caenorhabditis elegans germline stem cell proliferation and differentiation by PUF proteins FBF-1 and FBF-2.
Wang X, Ellenbecker M, Hickey B, Day NJ, Osterli E, Terzo M, Voronina E., Free PMC Article | 02/13/2021 |
| LST-1 weakens FBF-2 binding affinity for short and long motifs, which may increase target selectivity. | A crystal structure of a collaborative RNA regulatory complex reveals mechanisms to refine target specificity.
Qiu C, Bhat VD, Rajeev S, Zhang C, Lasley AE, Wine RN, Campbell ZT, Hall TMT., Free PMC Article | 02/8/2020 |
| Data indicate that a 10-amino-acid region in germline development defective-3 (GLD-3) is required for fem-3 binding factor (FBF) binding, while a 7-amino-acid loop in FBF between PUF repeats 7 and 8 is necessary for GLD-3 binding. | A protein.protein interaction platform involved in recruitment of GLD-3 to the FBF.fem-3 mRNA complex.
Wu J, Campbell ZT, Menichelli E, Wickens M, Williamson JR., Free PMC Article | 04/6/2013 |
| Data show that CPB-1 (cytoplasmic polyadenylation element binding protein homolog-1) alters the affinity of FBF (fem-3 mRNA binding factor) for specific RNA sequences. | Biochemical characterization of the Caenorhabditis elegans FBF.CPB-1 translational regulation complex identifies conserved protein interaction hotspots.
Menichelli E, Wu J, Campbell ZT, Wickens M, Williamson JR., Free PMC Article | 04/6/2013 |
| findings show FBF-1 and FBF-2 have different effects on target mRNAs; FBF-2 prevents translation; FBF-2 activity depends on PGL-1; PGL-1 is required to localize FBF-2 to perinuclear P granules and for efficient binding of FBF-2 to its mRNA targets | The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells.
Voronina E, Paix A, Seydoux G., Free PMC Article | 12/8/2012 |
| Data suggest that the FBF-2/GLD-2 protein directed polyadenylation of the endogenous mRNA, compensating for that mRNA's natural deadenylation. | Targeted translational regulation using the PUF protein family scaffold.
Cooke A, Prigge A, Opperman L, Wickens M., Free PMC Article | 12/17/2011 |
| The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells. | The Puf RNA-binding proteins FBF-1 and FBF-2 inhibit the expression of synaptonemal complex proteins in germline stem cells.
Merritt C, Seydoux G., Free PMC Article | 06/14/2010 |
| fbf-2 regulates the size of the mitotic region in helminth germ cells. | FBF-1 and FBF-2 regulate the size of the mitotic region in the C. elegans germline.
Lamont LB, Crittenden SL, Bernstein D, Wickens M, Kimble J. | 01/21/2010 |
| FBF may coordinately repress sperm-specifying mRNAs to direct oogenesis and it represses the fog-1 mRNA to maintain FOG-1 at a low level appropriate for proliferation | Dose-dependent control of proliferation and sperm specification by FOG-1/CPEB.
Thompson BE, Bernstein DS, Bachorik JL, Petcherski AG, Wickens M, Kimble J., Free PMC Article | 01/21/2010 |
| Fbf-2 redundantly inhibits primary vulval cell fate specification in two distinct pathways acting in the soma and in the germline | Distinct roles of the Pumilio and FBF translational repressors during C. elegans vulval development.
Walser CB, Battu G, Hoier EF, Hajnal A. | 01/21/2010 |