| Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFkappaBeta pathway inhibition. | Matrix metalloproteinase-10 deficiency has protective effects against peritoneal inflammation and fibrosis via transcription factor NFκΒ pathway inhibition.
Ishimura T, Ishii A, Yamada H, Osaki K, Toda N, Mori KP, Ohno S, Kato Y, Handa T, Sugioka S, Ikushima A, Nishio H, Yanagita M, Yokoi H. | 12/15/2023 |
| MMP10 alleviates non-alcoholic steatohepatitis by regulating macrophage M2 polarization. | MMP10 alleviates non-alcoholic steatohepatitis by regulating macrophage M2 polarization.
Chang L, Gao J, Yu Y, Liao B, Zhou Y, Zhang J, Ma X, Hou W, Zhou T, Xu Q. | 11/3/2023 |
| Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer. | Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer.
Dharavath B, Butle A, Pal A, Desai S, Upadhyay P, Rane A, Khandelwal R, Manavalan S, Thorat R, Sonawane K, Vaish R, Gera P, Bal M, D'Cruz AK, Nair S, Dutt A., Free PMC Article | 01/21/2023 |
| Expression of matrix metalloproteinase-3 and -10 is up-regulated in the periodontal tissues of aged mice. | Expression of matrix metalloproteinase-3 and -10 is up-regulated in the periodontal tissues of aged mice.
Kageyama Y, Nakamura M, Igari Y, Yamaguchi S, Oguchi A, Murakawa Y, Hattori Y, Sasano Y., Free PMC Article | 07/30/2022 |
| Elevated MMP10/13 mediated barrier disruption and NF-kappaB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice. | Elevated MMP10/13 mediated barrier disruption and NF-κB activation aggravate colitis and colon tumorigenesis in both individual or full miR-148/152 family knockout mice.
Tang K, Wu Z, Sun M, Huang X, Sun J, Shi J, Wang X, Miao Z, Gao P, Song Y, Wang Z. | 02/26/2022 |
| Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice. | Molecular and Cellular Mechanisms of Delayed Fracture Healing in Mmp10 (Stromelysin 2) Knockout Mice.
Valdés-Fernández J, López-Martínez T, Ripalda-Cemboráin P, Calvo IA, Sáez B, Romero-Torrecilla JA, Aldazabal J, Muiños-López E, Montiel V, Orbe J, Rodríguez JA, Páramo JA, Prósper F, Granero-Moltó F. | 01/1/2022 |
| Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria. | Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria.
Zuo Y, Wang C, Sun X, Hu C, Liu J, Hong X, Shen W, Nie J, Hou FF, Zhou L, Liu Y. | 10/23/2021 |
| Our results suggest that MMP-10 facilitates H. pylori persistence and promotes gastritis. | Helicobacter pylori-induced matrix metallopeptidase-10 promotes gastric bacterial colonization and gastritis.
Lv YP, Cheng P, Zhang JY, Mao FY, Teng YS, Liu YG, Kong H, Wu XL, Hao CJ, Han B, Ma Q, Yang SM, Chen W, Peng LS, Wang TT, Zou QM, Zhuang Y., Free PMC Article | 05/2/2020 |
| MMP10 plays a role in atherosclerosis, favoring inflammation, development and complication of the plaque | Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification.
Purroy A, Roncal C, Orbe J, Meilhac O, Belzunce M, Zalba G, Villa-Bellosta R, Andrés V, Parks WC, Páramo JA, Rodríguez JA. | 11/23/2019 |
| These results indicate that MMP10 serves a beneficial role in response to acute infection by moderating the proinflammatory response of resident and infiltrating macrophages. | Stromelysin-2 (MMP10) Moderates Inflammation by Controlling Macrophage Activation.
McMahan RS, Birkland TP, Smigiel KS, Vandivort TC, Rohani MG, Manicone AM, McGuire JK, Gharib SA, Parks WC., Free PMC Article | 08/12/2017 |
| MMP-10 facilitates the clearance of multiwalled carbon nanotubesand moderates the pro-inflammatory response of exposed alveolar and infiltrated macrophages. | Stromelysin-2 (MMP-10) facilitates clearance and moderates inflammation and cell death following lung exposure to long multiwalled carbon nanotubes.
Vandivort TC, Birkland TP, Domiciano TP, Mitra S, Kavanagh TJ, Parks WC., Free PMC Article | 04/22/2017 |
| crosstalk between MMP10 and the CXCR4/SDF1 axis contributes to hepatocarcinogenesis | Matrix metalloproteinase 10 contributes to hepatocarcinogenesis in a novel crosstalk with the stromal derived factor 1/C-X-C chemokine receptor 4 axis.
García-Irigoyen O, Latasa MU, Carotti S, Uriarte I, Elizalde M, Urtasun R, Vespasiani-Gentilucci U, Morini S, Benito P, Ladero JM, Rodriguez JA, Prieto J, Orbe J, Páramo JA, Fernández-Barrena MG, Berasain C, Avila MA. | 09/26/2015 |
| Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair. | Matrix metalloproteinase-10 expression is induced during hepatic injury and plays a fundamental role in liver tissue repair.
Garcia-Irigoyen O, Carotti S, Latasa MU, Uriarte I, Fernández-Barrena MG, Elizalde M, Urtasun R, Vespasiani-Gentilucci U, Morini S, Banales JM, Parks WC, Rodriguez JA, Orbe J, Prieto J, Páramo JA, Berasain C, Ávila MA. | 05/30/2015 |
| our findings support a model in which MMP-10 activity modulates CXCR4/SDF1 signaling, which is essential for efficient skeletal muscle regeneration. | The CXCR4/SDF1 axis improves muscle regeneration through MMP-10 activity.
Bobadilla M, Sainz N, Abizanda G, Orbe J, Rodriguez JA, Páramo JA, Prósper F, Pérez-Ruiz A., Free PMC Article | 02/14/2015 |
| Dissection of the matrix metalloproteinase 10 (MMP10) substrate degradome in fibroblast secretomes. | Time-resolved analysis of the matrix metalloproteinase 10 substrate degradome.
Schlage P, Egli FE, Nanni P, Wang LW, Kizhakkedathu JN, Apte SS, auf dem Keller U., Free PMC Article | 10/11/2014 |
| Thus, our findings indicate that MMP-10 is critical for skeletal muscle maintenance and regeneration during injury and disease. | MMP-10 is required for efficient muscle regeneration in mouse models of injury and muscular dystrophy.
Bobadilla M, Sáinz N, Rodriguez JA, Abizanda G, Orbe J, de Martino A, García Verdugo JM, Páramo JA, Prósper F, Pérez-Ruiz A. | 09/20/2014 |
| MMP10 promotes macrophage movement | Macrophage migration and invasion is regulated by MMP10 expression.
Murray MY, Birkland TP, Howe JD, Rowan AD, Fidock M, Parks WC, Gavrilovic J., Free PMC Article | 01/4/2014 |
| Assessed MMP-10's role in a murine model of colonic tissue damage induced by dextran sulfate sodium(DSS) treatment, and conclude MMP10 is required for resolution of DSS-induced colonic damage, and in its absence, chronic inflammation and dysplasia occurs. | Lack of MMP10 exacerbates experimental colitis and promotes development of inflammation-associated colonic dysplasia.
Koller FL, Dozier EA, Nam KT, Swee M, Birkland TP, Parks WC, Fingleton B., Free PMC Article | 04/20/2013 |
| Mmp10 is required for maintenance of a highly tumorigenic, cancer-initiating, metastatic stem-like cell population in lung cancer. | Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential.
Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP., Free PMC Article | 09/1/2012 |
| MMP-10 was capable of enhancing tissue plasminogen activator-induced fibrinolysis via a thrombin-activatable fibrinolysis inhibitor inactivation-mediated mechanism. | Matrix metalloproteinase-10 effectively reduces infarct size in experimental stroke by enhancing fibrinolysis via a thrombin-activatable fibrinolysis inhibitor-mediated mechanism.
Orbe J, Barrenetxe J, Rodriguez JA, Vivien D, Orset C, Parks WC, Birkland TP, Serrano R, Purroy A, Martinez de Lizarrondo S, Angles-Cano E, Páramo JA. | 02/18/2012 |
| Data show that S100a9, Mmp10 and Ang2 were among the most downregulated genes, whereas Per3, Tef and Prdx6 were significantly upregulated in the DMH + Calcium group. | Calcium prevents tumorigenesis in a mouse model of colorectal cancer.
Wang JL, Lin YW, Chen HM, Kong X, Xiong H, Shen N, Hong J, Fang JY., Free PMC Article | 02/18/2012 |
| Mmp10 is overexpressed in lung tumors induced by either the smoke carcinogen urethane or oncogenic Kras. | Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation.
Regala RP, Justilien V, Walsh MP, Weems C, Khoor A, Murray NR, Fields AP., Free PMC Article | 02/18/2012 |
| These findings support the hypothesis that CHF1/Hey2 is an important regulator of MMP10 expression. | Regulation of MMP10 expression by the transcription factor CHF1/Hey2 is mediated by multiple E boxes.
Wu L, Chien WM, Hartman ME, Moussavi-Harami F, Liu Y, Chin MT., Free PMC Article | 01/28/2012 |
| Data demonstrate induction of MMP-10 by VEGF in HUVEC and support an angiogenic role for MMP-10 in response to VEGF stimulation in vitro and in vivo. | Expression profiling of ETS and MMP factors in VEGF-activated endothelial cells: role of MMP-10 in VEGF-induced angiogenesis.
Heo SH, Choi YJ, Ryoo HM, Cho JY. | 08/23/2010 |
| This study examined the hypothesis that the control of NADPH oxidase-2 (Nox2)-mediated reactive oxygen species (ROS) regulates the expression of matrix metalloproteinases (MMPs) and the migration of macrophages. | Role of NADPH oxidase-2 in lipopolysaccharide-induced matrix metalloproteinase expression and cell migration.
Kim SY, Lee JG, Cho WS, Cho KH, Sakong J, Kim JR, Chin BR, Baek SH. | 05/31/2010 |