| The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells. | The Xbp1-regulated transcription factor Mist1 restricts antibody secretion by restraining Blimp1 expression in plasma cells.
Wöhner M, Pinter T, Bönelt P, Hagelkruys A, Kostanova-Poliakova D, Stadlmann J, Konieczny SF, Fischer M, Jaritz M, Busslinger M., Free PMC Article | 01/14/2023 |
| MIST1 plays an important role in organization of the Paneth cell secretory apparatus and managing endoplasmic reticulum stress. This role occurs downstream of Paneth cell lineage allocation. | Mist1 Expression Is Required for Paneth Cell Maturation.
Dekaney CM, King S, Sheahan B, Cortes JE., Free PMC Article | 07/25/2020 |
| Mist1 induces maturation of mouse fetal hepatoblasts. | The basic helix-loop-helix transcription factor, Mist1, induces maturation of mouse fetal hepatoblasts.
Chikada H, Ito K, Yanagida A, Nakauchi H, Kamiya A., Free PMC Article | 08/27/2016 |
| the transient silencing of Mist1 expression is critical for acinar cells to survive an acute pancreatitis episode. | Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis.
Karki A, Humphrey SE, Steele RE, Hess DA, Taparowsky EJ, Konieczny SF., Free PMC Article | 07/2/2016 |
| Mist1 expressing gastric stem cells maintain the normal/neoplastic gastric epithelium and are supported by a perivascular stem cell niche. | Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche.
Hayakawa Y, Ariyama H, Stancikova J, Sakitani K, Asfaha S, Renz BW, Dubeykovskaya ZA, Shibata W, Wang H, Westphalen CB, Chen X, Takemoto Y, Kim W, Khurana SS, Tailor Y, Nagar K, Tomita H, Hara A, Sepulveda AR, Setlik W, Gershon MD, Saha S, Ding L, Shen Z, Fox JG, Friedman RA, Konieczny SF, Worthley DL, Korinek V, Wang TC., Free PMC Article | 04/23/2016 |
| A total of 1,555 and 3,057 differentially expressed genes were identified in the wild type and Mist1 knock-out mice with caerulein-induced pancreatitis. | Identification of key transcription factors in caerulein-induced pancreatitis through expression profiling data.
Qi D, Wu B, Tong D, Pan Y, Chen W., Free PMC Article | 03/5/2016 |
| Mist1 deficiency predicts the molecular response to experimental pancreatitis. | Epigenetic reprogramming in Mist1(-/-) mice predicts the molecular response to cerulein-induced pancreatitis.
Mehmood R, Varga G, Mohanty SQ, Laing SW, Lu Y, Johnson CL, Kharitonenkov A, Pin CL., Free PMC Article | 11/8/2014 |
| Chromatin immunopreciptation indicated that the loss of Fgf21 in the Mist1(-/-) pancreas is due, in part, to epigenetic silencing. | Silencing of the Fibroblast growth factor 21 gene is an underlying cause of acinar cell injury in mice lacking MIST1.
Johnson CL, Mehmood R, Laing SW, Stepniak CV, Kharitonenkov A, Pin CL. | 06/7/2014 |
| These results suggest that maintaining MIST1 activity in Kras(G12D)-expressing acinar cells can partially mitigate the transformation activity of oncogenic KRAS. | Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia.
Shi G, DiRenzo D, Qu C, Barney D, Miley D, Konieczny SF., Free PMC Article | 06/22/2013 |
| Activation of protein kinase Cdelta leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1. | Activation of protein kinase Cδ leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.
Johnson CL, Peat JM, Volante SN, Wang R, McLean CA, Pin CL. | 01/12/2013 |
| The exocrine pancreas of adult mice can be remodeled by re-expression of the transcription factor MIST1. MIST1 regulates acinar cell maturation and might be used to repair damaged pancreata in patients with pancreatic disorders. | Induced Mist1 expression promotes remodeling of mouse pancreatic acinar cells.
Direnzo D, Hess DA, Damsz B, Hallett JE, Marshall B, Goswami C, Liu Y, Deering T, Macdonald RJ, Konieczny SF., Free PMC Article | 10/6/2012 |
| findings suggest that an absence of MIST1 increases the sensitivity to ethanol that correlated with decreased activity of the unfolded protein response | The absence of MIST1 leads to increased ethanol sensitivity and decreased activity of the unfolded protein response in mouse pancreatic acinar cells.
Alahari S, Mehmood R, Johnson CL, Pin CL., Free PMC Article | 05/26/2012 |
| MIST1 is enriched upon plasma cell differentiation. | Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells.
Capoccia BJ, Lennerz JK, Bredemeyer AJ, Klco JM, Frater JL, Mills JC., Free PMC Article | 07/30/2011 |
| XBP1 controls the transcriptional regulation of zymogenic cell structural development; it expands the lamellar rough endoplasmic reticulum and induces MIST1 expression to regulate formation of large granules | XBP1 controls maturation of gastric zymogenic cells by induction of MIST1 and expansion of the rough endoplasmic reticulum.
Huh WJ, Esen E, Geahlen JH, Bredemeyer AJ, Lee AH, Shi G, Konieczny SF, Glimcher LH, Mills JC., Free PMC Article | 01/8/2011 |
| Atp2c2 transcription is regulated by MIST1 | MIST1 regulates the pancreatic acinar cell expression of Atp2c2, the gene encoding secretory pathway calcium ATPase 2.
Garside VC, Kowalik AS, Johnson CL, DiRenzo D, Konieczny SF, Pin CL., Free PMC Article | 11/13/2010 |
| MIST1 binds to highly conserved CATATG E-boxes to directly activate transcription of 6 genes, including those encoding the small GTPases RAB26 and RAB3D. | RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation.
Tian X, Jin RU, Bredemeyer AJ, Oates EJ, Błazewska KM, McKenna CE, Mills JC., Free PMC Article | 03/29/2010 |
| Convergence of EGFR, Notch, and Kras pathways in acinar cells lacking Mist1 leads to enhanced pancreatic intraepithelial neoplasia formation. | Loss of the acinar-restricted transcription factor Mist1 accelerates Kras-induced pancreatic intraepithelial neoplasia.
Shi G, Zhu L, Sun Y, Bettencourt R, Damsz B, Hruban RH, Konieczny SF., Free PMC Article | 01/21/2010 |
| Mist1 has a dual role in the development of the exocrine pancreas: controlling cell proliferation and promoting terminal differentiation. | Mist1 regulates pancreatic acinar cell proliferation through p21 CIP1/WAF1.
Jia D, Sun Y, Konieczny SF., Free PMC Article | 01/21/2010 |
| This study identified BHLHB8 as a regulator in establishing and stabilizing the secreting epithelial cells of the seminal vesicle. | Identification of a transcription factor, BHLHB8, involved in mouse seminal vesicle epithelium differentiation and function.
Pin CL, Johnson CL, Rade B, Kowalik AS, Garside VC, Everest ME. | 01/21/2010 |
| Spasmolytic polypeptide/trefoil factor family 2 (TFF2)-expressing metaplasia (SPEM)was immunoreactive for TFF2, Mist1 and intrinsic factor, suggesting that SPEM derived from transdifferentiation of chief cells. | A molecular signature of gastric metaplasia arising in response to acute parietal cell loss.
Nozaki K, Ogawa M, Williams JA, Lafleur BJ, Ng V, Drapkin RI, Mills JC, Konieczny SF, Nomura S, Goldenring JR., Free PMC Article | 01/21/2010 |
| Mist1 functions as a positive regulator of Cx32 gene expression and, sustans acinar cell gap junctions and intercellular communication pathways | Exocrine specific expression of Connexin32 is dependent on the basic helix-loop-helix transcription factor Mist1.
Rukstalis JM, Kowalik A, Zhu L, Lidington D, Pin CL, Konieczny SF. | 01/21/2010 |
| Mist1 is necessary for complete differentiation and maturation of serous exocrine cells through the combined regulation of several exocrine specific genes. | Mist1 is necessary for the establishment of granule organization in serous exocrine cells of the gastrointestinal tract.
Johnson CL, Kowalik AS, Rajakumar N, Pin CL. | 01/21/2010 |
| Mist1 is critical to normal organelle localization in exocrine cells | Aberrant localization of intracellular organelles, Ca2+ signaling, and exocytosis in Mist1 null mice.
Luo X, Shin DM, Wang X, Konieczny SF, Muallem S. | 01/21/2010 |
| The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1. | The maturation of mucus-secreting gastric epithelial progenitors into digestive-enzyme secreting zymogenic cells requires Mist1.
Ramsey VG, Doherty JM, Chen CC, Stappenbeck TS, Konieczny SF, Mills JC. | 01/21/2010 |
| Mist1 knock out islets have increased resistance to strepttozotocin,likely due to a decreased accumulation of Glut-2 | Mist1-null mice are resistant to streptozotocin-induced beta cell damage.
Fazio EN, Pin CL. | 01/21/2010 |