| Deletion of beaded filament proteins or the C-terminal end of Aquaporin 0 causes analogous abnormal distortion aberrations in mouse lens. | Deletion of beaded filament proteins or the C-terminal end of Aquaporin 0 causes analogous abnormal distortion aberrations in mouse lens.
Varadaraj K, FitzGerald PG, Kumari SS., Free PMC Article | 12/4/2021 |
| Lenses expressing only C-terminally end-cleaved aquaporin-0 show loss of transparency. | A predominant form of C-terminally end-cleaved AQP0 functions as an open water channel and an adhesion protein in AQP0(ΔC/ΔC) mouse lens.
Kumari SS, Varadaraj K., Free PMC Article | 01/25/2020 |
| A specific distribution profile of intact and end-cleaved AQP0 from the outer cortex to the inner nucleus is required in the lens for establishing refractive index gradient to enable proper focusing without aberrations and for maintaining transparency. | Deletion of Seventeen Amino Acids at the C-Terminal End of Aquaporin 0 Causes Distortion Aberration and Cataract in the Lenses of AQP0ΔC/ΔC Mice.
Varadaraj K, Kumari S., Free PMC Article | 08/17/2019 |
| positively charged amino acids in the AQP0 extracellular loop domains interact with the negatively charged lipids in the plasma membrane to promote cell-to-cell adhesion for compaction of fiber cells. | Molecular mechanism of Aquaporin 0-induced fiber cell to fiber cell adhesion in the eye lens.
Varadaraj K, Kumari SS., Free PMC Article | 05/25/2019 |
| Cataractogenesis in Mip(Nat) mutants are caused by defects in MIP expression. | A novel missense mutation of Mip causes semi-dominant cataracts in the Nat mouse.
Takahashi G, Hasegawa S, Fukutomi Y, Harada C, Furugori M, Seki Y, Kikkawa Y, Wada K., Free PMC Article | 09/30/2017 |
| These data suggest that while relatively few genes ( approximately 1.5% of the transcriptome) were differentially regulated >2-fold in the Mip-/- lens, calpain hyper-activation acts as a terminal pathogenic event during lens fiber cell death and cataract formation. | Lens transcriptome profile during cataract development in Mip-null mice.
Bennett TM, Zhou Y, Shiels A., Free PMC Article | 06/3/2017 |
| hypothesize that AQP0, with its prolific expression at the fiber cell membrane, could provide anchorage for cytoskeletal structures like BFs and together they help to confer fiber cell shape, architecture and integrity | Role of Aquaporin 0 in lens biomechanics.
Sindhu Kumari S, Gupta N, Shiels A, FitzGerald PG, Menon AG, Mathias RT, Varadaraj K., Free PMC Article | 08/29/2015 |
| In summary, lens transparency, CTCA and compact packing of fiber cells were affected due to the loss of 50% AQP0 leading to larger extracellular space, more water content and SA, possibly due to alteration in RING. | Aquaporin 0 plays a pivotal role in refractive index gradient development in mammalian eye lens to prevent spherical aberration.
Kumari SS, Varadaraj K., Free PMC Article | 12/6/2014 |
| Post-translational truncation of N- or C-terminal end amino acids does not alter the basal water permeability of AQP0 or its adhesive functions. | Intact and N- or C-terminal end truncated AQP0 function as open water channels and cell-to-cell adhesion proteins: end truncation could be a prelude for adjusting the refractive index of the lens to prevent spherical aberration.
Sindhu Kumari S, Varadaraj K., Free PMC Article | 10/4/2014 |
| Data show that Ca(V) 1.2 and 1.3 channels are expressed in lens, regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins 50 and 46. | L-type calcium channels play a critical role in maintaining lens transparency by regulating phosphorylation of aquaporin-0 and myosin light chain and expression of connexins.
Maddala R, Nagendran T, de Ridder GG, Schey KL, Rao PV., Free PMC Article | 01/11/2014 |
| The additional negative charge introduced by phosphoserine 235 perturbs electrostatic interactions between aquaporin-0 and calmodulin to favour water influx through the channel. | AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency.
Gold MG, Reichow SL, O'Neill SE, Weisbrod CR, Langeberg LK, Bruce JE, Gonen T, Scott JD., Free PMC Article | 04/21/2012 |
| increased water permeability through AQP1 does not compensate for loss of AQP0 expression in TgAQP1(+/+)/AQP0(-/-) mice. Fiber cell AQP0 expression is required to maintain their organization, which is a requisite for lens transparency | Unique and analogous functions of aquaporin 0 for fiber cell architecture and ocular lens transparency.
Kumari SS, Eswaramoorthy S, Mathias RT, Varadaraj K., Free PMC Article | 09/17/2011 |
| Kynurenine might inhibit FGF2-mediated fiber cell differentiation by preventing expression of crystallins and MIP26. | Kynurenine inhibits fibroblast growth factor 2-mediated expression of crystallins and MIP26 in lens epithelial cells.
Mailankot M, Howell S, Nagaraj RH., Free PMC Article | 08/16/2010 |
| MIP has essential roles in the establishment and maintenance of uniform fiber structure, and the organization of fibers, and as such is essential for lens function. | Lens structure in MIP-deficient mice.
Al-Ghoul KJ, Kirk T, Kuszak AJ, Zoltoski RK, Shiels A, Kuszak JR. | 01/21/2010 |
| study provides the first evidence that calcium regulation of AQP0 water permeability may be crucial for maintaining normal lens homeostasis and development | AQP0-LTR of the Cat Fr mouse alters water permeability and calcium regulation of wild type AQP0.
Kalman K, Németh-Cahalan KL, Froger A, Hall JE. | 01/21/2010 |