| Role of Matrix Gla Protein in Transforming Growth Factor-beta Signaling and Nonalcoholic Steatohepatitis in Mice. | Role of Matrix Gla Protein in Transforming Growth Factor-β Signaling and Nonalcoholic Steatohepatitis in Mice.
Hui ST, Gong L, Swichkow C, Blencowe M, Kaminska D, Diamante G, Pan C, Dalsania M, French SW, Magyar CE, Pajukanta P, Pihlajamäki J, Boström KI, Yang X, Lusis AJ., Free PMC Article | 11/22/2023 |
| Specific heterozygous variants in MGP lead to endoplasmic reticulum stress and cause spondyloepiphyseal dysplasia. | Specific heterozygous variants in MGP lead to endoplasmic reticulum stress and cause spondyloepiphyseal dysplasia.
Gourgas O, Lemire G, Eaton AJ, Alshahrani S, Duker AL, Li J, Carroll RS, Mackenzie S, Nikkel SM, Care4Rare Canada Consortium, Bober MB, Boycott KM, Murshed M., Free PMC Article | 11/8/2023 |
| Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer. | Matrix Gla Protein drives stemness and tumor initiation in ovarian cancer.
Nieddu V, Melocchi V, Battistini C, Franciosa G, Lupia M, Stellato C, Bertalot G, Olsen JV, Colombo N, Bianchi F, Cavallaro U., Free PMC Article | 04/4/2023 |
| A preliminary study exploring the mechanical properties of normal and Mgp-deficient mouse femurs during early growth. | A preliminary study exploring the mechanical properties of normal and Mgp-deficient mouse femurs during early growth.
Laurent C, Marano A, Baldit A, Ferrari M, Perrin JC, Perroud O, Bianchi A, Kempf H. | 08/27/2022 |
| Prevention of Arterial Elastocalcinosis: Differential Roles of the Conserved Glutamic Acid and Serine Residues of Matrix Gla Protein. | Prevention of Arterial Elastocalcinosis: Differential Roles of the Conserved Glutamic Acid and Serine Residues of Matrix Gla Protein.
Parashar A, Bak K, Murshed M. | 06/11/2022 |
| MGP promotes CD8(+) T cell exhaustion by activating the NF-kappaB pathway leading to liver metastasis of colorectal cancer. | MGP promotes CD8(+) T cell exhaustion by activating the NF-κB pathway leading to liver metastasis of colorectal cancer.
Rong D, Sun G, Zheng Z, Liu L, Chen X, Wu F, Gu Y, Dai Y, Zhong W, Hao X, Zhang C, Pan X, Tang J, Tang W, Wang X., Free PMC Article | 04/23/2022 |
| Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction. | Matrix Gla Protein Levels Are Associated With Arterial Stiffness and Incident Heart Failure With Preserved Ejection Fraction.
Malhotra R, Nicholson CJ, Wang D, Bhambhani V, Paniagua S, Slocum C, Sigurslid HH, Lino Cardenas CL, Li R, Boerboom SL, Chen YC, Hwang SJ, Yao C, Ichinose F, Bloch DB, Lindsay ME, Lewis GD, Aragam JR, Hoffmann U, Mitchell GF, Hamburg NM, Vasan RS, Benjamin EJ, Larson MG, Zapol WM, Cheng S, Roh JD, O'Donnell CJ, Nguyen C, Levy D, Ho JE., Free PMC Article | 02/19/2022 |
| Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity. | Matrix Gla protein regulates adipogenesis and is serum marker of visceral adiposity.
Li C, Li J, He F, Li K, Li X, Zhang Y., Free PMC Article | 02/27/2021 |
| Observations establish, for the first time, that MGP plays an essential role in osteoclast differentiation and function. The molecular evidence indicates that MGP controls osteoclastogenesis via modulation of the intracellular calcium flux and Src/Rac1 signaling. | Unexpected Role of Matrix Gla Protein in Osteoclasts: Inhibiting Osteoclast Differentiation and Bone Resorption.
Zhang Y, Zhao L, Wang N, Li J, He F, Li X, Wu S., Free PMC Article | 02/8/2020 |
| We propose MGP as a strong candidate for the regulation of stiffness in glaucoma. MGP further illustrates the presence of a common function affecting key glaucomatous parameters in the front and back of the eye, and thus offers the possibility for a sole therapeutic target for the disease. | A single gene connects stiffness in glaucoma and the vascular system.
Borrás T., Free PMC Article | 07/22/2017 |
| the nasal septum to be abnormally mineralized and shortened in Mgp(-/-) mice. Transgenic restoration of Mgp expression in chondrocytes fully corrected the craniofacial anomalies caused by MGP deficiency, suggesting a local role for MGP in the developing nasal septum. | Matrix Gla protein deficiency impairs nasal septum growth, causing midface hypoplasia.
Marulanda J, Eimar H, McKee MD, Berkvens M, Nelea V, Roman H, Borrás T, Tamimi F, Ferron M, Murshed M., Free PMC Article | 07/15/2017 |
| loss of MGP causes dysregulation of early endothelial differentiation. | Matrix Gla protein regulates differentiation of endothelial cells derived from mouse embryonic stem cells.
Yao J, Guihard PJ, Blazquez-Medela AM, Guo Y, Liu T, Boström KI, Yao Y., Free PMC Article | 10/1/2016 |
| Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 deficiency. | Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 deficiency.
Boström KI, Guihard P, Blazquez Medela AM, Yao J, Moon JH, Penton A, Yao Y., Free PMC Article | 12/19/2015 |
| expression of MGP and OCN increased gradually in the murine developing tibial epiphysis, and the two mineral-associated proteins may occur at the same location during a particular period, but at different levels. | Expression of matrix Gla protein and osteocalcin in the developing tibial epiphysis of mice.
Liu H, Guo J, Wei S, Lv S, Feng W, Cui J, Hasegawa T, Hongo H, Yang Y, Li X, Oda K, Amizuka N, Li M. | 09/5/2015 |
| Matrix Gla's restricted expression to glaucoma-associated tissues from anterior and posterior segments suggests its involvement in the development of the disease. | A Novel Mgp-Cre Knock-In Mouse Reveals an Anticalcification/Antistiffness Candidate Gene in the Trabecular Meshwork and Peripapillary Scleral Region.
Borrás T, Smith MH, Buie LK., Free PMC Article | 08/29/2015 |
| Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice. | Elastin haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.
Khavandgar Z, Roman H, Li J, Lee S, Vali H, Brinckmann J, Davis EC, Murshed M. | 09/6/2014 |
| The arterial calcification, not MGP deficiency itself, causes the low bone mass phenotype in Mgp-/- mice. | Prevention of arterial calcification corrects the low bone mass phenotype in MGP-deficient mice.
Marulanda J, Gao C, Roman H, Henderson JE, Murshed M. | 06/14/2014 |
| Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 and elastin fragmentation associated with induction of adipsin. | Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 and elastin fragmentation associated with induction of adipsin.
Beazley KE, Reckard S, Nurminsky D, Lima F, Nurminskaya M., Free PMC Article | 01/4/2014 |
| MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways | Matrix Gla protein reinforces angiogenic resolution.
Sharma B, Albig AR., Free PMC Article | 06/29/2013 |
| Mgp gene deletion may have a role in arteriovenous malformations | Matrix Gla protein deficiency causes arteriovenous malformations in mice.
Yao Y, Jumabay M, Wang A, Boström KI., Free PMC Article | 10/8/2011 |
| Inorganic phosphate regulates MGP expression in osteoblasts through the ERK1/2-Fra-1 pathway. | Phosphate-dependent regulation of MGP in osteoblasts: role of ERK1/2 and Fra-1.
Julien M, Khoshniat S, Lacreusette A, Gatius M, Bozec A, Wagner EF, Wittrant Y, Masson M, Weiss P, Beck L, Magne D, Guicheux J. | 01/21/2010 |
| Oral anticoagulant treatment decreased local expression of MGP. | Relation of circulating Matrix Gla-Protein and anticoagulation status in patients with aortic valve calcification.
Koos R, Krueger T, Westenfeld R, Kühl HP, Brandenburg V, Mahnken AH, Stanzel S, Vermeer C, Cranenburg EC, Floege J, Kelm M, Schurgers LJ. | 01/21/2010 |
| Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein. | Heat shock protein 70 enhances vascular bone morphogenetic protein-4 signaling by binding matrix Gla protein.
Yao Y, Watson AD, Ji S, Boström KI., Free PMC Article | 01/21/2010 |
| Extensive hypomineralization was observed in dentin and alveolar bone from transgenic mice expressing matrix Gla protein when compared with that in wild-type tissues. Mineralization was virtually absent in tooth root dentin and cellular cementum. | Matrix Gla protein inhibition of tooth mineralization.
Kaipatur NR, Murshed M, McKee MD. | 01/21/2010 |
| PTH regulates MGP via both PKA- and ERK-dependent pathways. | Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways.
Suttamanatwong S, Franceschi RT, Carlson AE, Gopalakrishnan R. | 01/21/2010 |