| FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton. | FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton.
Almubarak A, Zhang Q, Zhang CH, Abdelwahab N, Kume T, Lassar AB, Berry FB., Free PMC Article | 10/25/2024 |
| FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal angiogenesis and blood-retina barrier formation. | FOXC1 regulates endothelial CD98 (LAT1/4F2hc) expression in retinal angiogenesis and blood-retina barrier formation.
Bhakuni T, Norden PR, Ujiie N, Tan C, Lee SK, Tedeschi T, Hsieh YW, Wang Y, Liu T, Fawzi AA, Kume T., Free PMC Article | 07/9/2024 |
| Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5. | Silencing of forkhead box C1 reduces nasal epithelial barrier damage in mice with allergic rhinitis via epigenetically upregulating secreted frizzled-related protein 5.
Shi Z, Zhao T, Li D, Wang C, Luo Y, Zheng Y. | 03/14/2024 |
| FOXC1 Promotes Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells via the Dnmt3b/CXCL12 Axis. | FOXC1 Promotes Osteoblastic Differentiation of Bone Marrow Mesenchymal Stem Cells via the Dnmt3b/CXCL12 Axis.
Zhang P, Feng B, Dai G, Niu K, Zhang L. | 03/1/2024 |
| Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury. | Endothelial FOXC1 and FOXC2 promote intestinal regeneration after ischemia-reperfusion injury.
Tan C, Norden PR, Yu W, Liu T, Ujiie N, Lee SK, Yan X, Dyakiv Y, Aoto K, Ortega S, De Plaen IG, Sampath V, Kume T., Free PMC Article | 07/12/2023 |
| Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification. | Loss of Foxc1 and Foxc2 function in chondroprogenitor cells disrupts endochondral ossification.
Almubarak A, Lavy R, Srnic N, Hu Y, Maripuri DP, Kume T, Berry FB., Free PMC Article | 12/11/2021 |
| FOXC1 negatively regulates BMP-SMAD activity and Id1 expression during osteoblast differentiation. | FOXC1 negatively regulates BMP-SMAD activity and Id1 expression during osteoblast differentiation.
Caddy JC, Luoma LM, Berry FB. | 07/10/2021 |
| Conditional inactivation of Foxc1 and Foxc2 in neural crest cells leads to cardiac abnormalities. | Conditional inactivation of Foxc1 and Foxc2 in neural crest cells leads to cardiac abnormalities.
Sanchez J, Miyake R, Cheng A, Liu T, Iseki S, Kume T., Free PMC Article | 02/6/2021 |
| Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrP(C) signaling. | Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrP(C) signaling.
Lee YH, Lee HT, Chen CL, Chang CH, Hsu CY, Shyu WC., Free PMC Article | 10/24/2020 |
| FOXC1 up-regulates the expression of toll-like receptors in myocardial ischaemia. | FOXC1 up-regulates the expression of toll-like receptors in myocardial ischaemia.
Zhang SP, Yang RH, Shang J, Gao T, Wang R, Peng XD, Miao X, Pan L, Yuan WJ, Lin L, Hu QK., Free PMC Article | 09/12/2020 |
| Overexpression of miR-103-3p inhibited forkhead transcription factor C1 (Foxc1)-promoted osteogenic differentiation and special AT-rich sequence-binding protein 2 (Satb2) expression. | Satb2 expression in Foxc1-promoted osteogenic differentiation of MC3T3-E1 cells is negatively regulated by microRNA-103-3p.
Shen H, Lu C, Shi J, Li H, Si J, Shen G. | 12/21/2019 |
| High FOXC1 expression is associated with pulmonary hypertension. | LncRNA Tug1 involves in the pulmonary vascular remodeling in mice with hypoxic pulmonary hypertension via the microRNA-374c-mediated Foxc1.
Yang L, Liang H, Shen L, Guan Z, Meng X. | 11/30/2019 |
| FOXC1 is a regulator of mammary gland development. | Inhibition of lobuloalveolar development by FOXC1 overexpression in the mouse mammary gland.
Gao B, Qu Y, Han B, Nagaoka Y, Katsumata M, Deng N, Bose S, Jin L, Giuliano AE, Cui X., Free PMC Article | 07/20/2019 |
| siRNA-mediated knockdown of FOXC1 was confirmed to decrease the proliferation rate, migration, and invasion in a model Basal-like breast cancer-like cell line (4T1). | Evaluation of FOXC1 as a therapeutic target for basal-like breast cancer.
Mott L, Su K, Pack DW. | 03/2/2019 |
| Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program driven by FOXC1. | Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program.
Hirukawa A, Smith HW, Zuo D, Dufour CR, Savage P, Bertos N, Johnson RM, Bui T, Bourque G, Basik M, Giguère V, Park M, Muller WJ., Free PMC Article | 12/22/2018 |
| These findings suggest that Foxc1 is an important regulator to further chondrogenesis and initiate the ossification of the presphenoid and basisphenoid bones. | Transcription factor Foxc1 is involved in anterior part of cranial base formation.
Mya N, Furutera T, Okuhara S, Kume T, Takechi M, Iseki S. | 12/1/2018 |
| Lineage tracing experiments in Foxc1 mutant mouse cerebella indicate that aberrant migration of granule cell progenitors destined to form the posterior-most lobule causes this cerebellar malformation phenotype. | Phenotypic outcomes in Mouse and Human Foxc1 dependent Dandy-Walker cerebellar malformation suggest shared mechanisms.
Haldipur P, Dang D, Aldinger KA, Janson OK, Guimiot F, Adle-Biasette H, Dobyns WB, Siebert JR, Russo R, Millen KJ., Free PMC Article | 02/17/2018 |
| Foxc1 regulates both early cardiomyogenesis and the functional properties of embryonic stem cell-derived cardiomyocytes. | Foxc1 Regulates Early Cardiomyogenesis and Functional Properties of Embryonic Stem Cell Derived Cardiomyocytes.
Lambers E, Arnone B, Fatima A, Qin G, Wasserstrom JA, Kume T. | 12/9/2017 |
| FOXC1 and FOXC2 are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases | Foxc1 and Foxc2 deletion causes abnormal lymphangiogenesis and correlates with ERK hyperactivation.
Fatima A, Wang Y, Uchida Y, Norden P, Liu T, Culver A, Dietz WH, Culver F, Millay M, Mukouyama YS, Kume T., Free PMC Article | 09/30/2017 |
| These data indicate that Foxc1 expression is regulated by BMP4 and FOXC1 functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds. | Foxc1 Expression in Early Osteogenic Differentiation Is Regulated by BMP4-SMAD Activity.
Hopkins A, Mirzayans F, Berry F. | 09/16/2017 |
| Foxc1 regulates sweat duct luminal cell differentiation and mimic apocrine miliaria. | Foxc1 Ablated Mice Are Anhidrotic and Recapitulate Features of Human Miliaria Sweat Retention Disorder.
Cui CY, Ishii R, Campbell DP, Michel M, Piao Y, Kume T, Schlessinger D., Free PMC Article | 07/22/2017 |
| Compound, NC-specific Foxc1; Foxc2 homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2, and its downstream effector Dkk2, which antagonizes canonical Wnt signaling. | Foxc1 and Foxc2 in the Neural Crest Are Required for Ocular Anterior Segment Development.
Seo S, Chen L, Liu W, Zhao D, Schultz KM, Sasman A, Liu T, Zhang HF, Gage PJ, Kume T., Free PMC Article | 07/1/2017 |
| These findings offer the first evidence for a role of the meninges in brain vascular development and provide new insight into potential causes of cerebrovascular defects in patients with FOXC1 mutations. | Cerebrovascular defects in Foxc1 mutants correlate with aberrant WNT and VEGF-A pathways downstream of retinoic acid from the meninges.
Mishra S, Choe Y, Pleasure SJ, Siegenthaler JA., Free PMC Article | 06/10/2017 |
| Foxc1 and Foxc2 maintain glomerular podocyte integrity by regulating the gene expression. | Foxc1 and Foxc2 are necessary to maintain glomerular podocytes.
Motojima M, Kume T, Matsusaka T. | 05/27/2017 |
| Foxc1 and Foxc2 have a role in kidney and axial skeleton development. | Characterization of Kidney and Skeleton Phenotypes of Mice Double Heterozygous for Foxc1 and Foxc2.
Motojima M, Tanimoto S, Ohtsuka M, Matsusaka T, Kume T, Abe K. | 03/11/2017 |