| Presynaptic Galphao (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans. | Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans.
Ravi B, Zhao J, Chaudhry SI, Signorelli R, Bartole M, Kopchock RJ, Guijarro C, Kaplan JM, Kang L, Collins KM., Free PMC Article | 03/19/2022 |
| Mutations in tra-1 and goa-1 decouple behavioural patterns from the number of X chromosomes. TRA-1 binds to a conserved binding site located in the goa-1 coding region, and downregulates goa-1 expression in hermaphrodites, particularly during embryogenesis when neuronal development largely occurs. | Sex-specific regulation of neuronal functions in Caenorhabditis elegans: the sex-determining protein TRA-1 represses goa-1/Gα((i/o)).
Kutnyánszky V, Hargitai B, Hotzi B, Kosztelnik M, Ortutay C, Kovács T, Győry E, Bördén K, Princz A, Tavernarakis N, Vellai T. | 03/7/2020 |
| Exogenous arachidonoyl ethanolamide inhibits axon regeneration via the Goalpha subunit GOA-1, which antagonizes the Gqalpha subunit EGL-30. | Endocannabinoid-Goα signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gqα-PKC-JNK signalling.
Pastuhov SI, Fujiki K, Nix P, Kanao S, Bastiani M, Matsumoto K, Hisamoto N., Free PMC Article | 02/12/2018 |
| Following food deprivation G protein alpha(o) is activated via RIC-8 activation. | AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo.
Hofler C, Koelle MR., Free PMC Article | 10/8/2011 |
| Goa-1 Goalpha and let-60 Ras act in parallel to gpc-1 in olfactory pathways. | GPC-1, a G protein gamma-subunit, regulates olfactory adaptation in Caenorhabditis elegans.
Yamada K, Hirotsu T, Matsuki M, Kunitomo H, Iino Y., Free PMC Article | 01/21/2010 |
| Serotonin signaling is regulated by modulating serotonin biosynthesis and Galphao and Galphaq act in the same neurons to have opposing effects on behavior, in part, by antagonistically regulating transcription of specific genes. | Regulation of serotonin biosynthesis by the G proteins Galphao and Galphaq controls serotonin signaling in Caenorhabditis elegans.
Tanis JE, Moresco JJ, Lindquist RA, Koelle MR., Free PMC Article | 01/21/2010 |
| These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction. | Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II.
Goulding MB, Canman JC, Senning EN, Marcus AH, Bowerman B., Free PMC Article | 01/21/2010 |
| findings show that the GoLoco-containing proteins GPR-1 and GPR-2, as well as the Galpha subunits GOA-1 and GPA-16, were essential for generation of proper pulling forces in asymmetric spindle positioning | Translation of polarity cues into asymmetric spindle positioning in Caenorhabditis elegans embryos.
Colombo K, Grill SW, Kimple RJ, Willard FS, Siderovski DP, Gönczy P. | 01/21/2010 |
| The stravation response is fully dependent on the subsequent activation of the G alpha(q) ortholog EGL-30. | Starvation induces cAMP response element-binding protein-dependent gene expression through octopamine-Gq signaling in Caenorhabditis elegans.
Suo S, Kimura Y, Van Tol HH., Free PMC Article | 01/21/2010 |
| Data show that the asymmetry of GPR-1/2 (which act with GOA-1 and GPA-16) localization depends on PAR-3 and its downstream intermediate LET-99, as well as on the MES-1/SRC-1 signaling pathway. | LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling.
Tsou MF, Hayashi A, Rose LS. | 01/21/2010 |
| Our results suggest that EGL-47 regulates egg laying by activating Galpha(o) in the hermaphrodite-specific motor neurons to inhibit their activity. | Activation of EGL-47, a Galpha(o)-coupled receptor, inhibits function of hermaphrodite-specific motor neurons to regulate Caenorhabditis elegans egg-laying behavior.
Moresco JJ, Koelle MR., Free PMC Article | 01/21/2010 |
| down-regulation of EGL-30-DAG signaling by GOA-1 underlies olfactory adaptation and plasticity of chemotaxis | Goalpha regulates olfactory adaptation by antagonizing Gqalpha-DAG signaling in Caenorhabditis elegans.
Matsuki M, Kunitomo H, Iino Y., Free PMC Article | 01/21/2010 |