| Mannan-Binding Lectin Promotes Murine Graft-versus-Host Disease by Amplifying Lipopolysaccharide-Initiated Inflammation. | Mannan-Binding Lectin Promotes Murine Graft-versus-Host Disease by Amplifying Lipopolysaccharide-Initiated Inflammation.
Heja D, Zhao D, Cody E, Cumpelik A, Lim PC, Prado-Acosta M, Palma L, Dellepiane S, Chun N, Ferrara J, Heeger PS., Free PMC Article | 08/13/2022 |
| Mannose-binding lectin activates the nuclear factor-kappaB and renal inflammation in the progression of diabetic nephropathy. | Mannose-binding lectin activates the nuclear factor-κB and renal inflammation in the progression of diabetic nephropathy.
Ma Y, Cai F, Huang X, Wang H, Yu B, Wang J, Nie W, Cai K, Yang Y, Chen J, Xiao L, Han F. | 03/5/2022 |
| Mannose-binding lectin promotes blood-brain barrier breakdown and exacerbates axonal damage after traumatic brain injury in mice. | Mannose-binding lectin promotes blood-brain barrier breakdown and exacerbates axonal damage after traumatic brain injury in mice.
Pedragosa J, Mercurio D, Oggioni M, Marquez-Kisinousky L, de Simoni MG, Planas AM. | 12/25/2021 |
| Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury. | Specific contribution of mannose-binding lectin murine isoforms to brain ischemia/reperfusion injury.
Neglia L, Oggioni M, Mercurio D, De Simoni MG, Fumagalli S., Free PMC Article | 06/5/2021 |
| Mannan-binding lectin promotes keratinocyte to produce CXCL1 and enhances neutrophil infiltration at the early stages of psoriasis. | Mannan-binding lectin promotes keratinocyte to produce CXCL1 and enhances neutrophil infiltration at the early stages of psoriasis.
Zeng J, Chen X, Lei K, Wang D, Lin L, Wang Y, Li Y, Liu Y, Zhang L, Zuo D, Sun L. | 10/24/2020 |
| work shows that pathogenic fungi promote pancreatic ductal adenocarcinoma by driving the complement cascade through the activation of MBL | The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL.
Aykut B, Pushalkar S, Chen R, Li Q, Abengozar R, Kim JI, Shadaloey SA, Wu D, Preiss P, Verma N, Guo Y, Saxena A, Vardhan M, Diskin B, Wang W, Leinwand J, Kurz E, Kochen Rossi JA, Hundeyin M, Zambrinis C, Li X, Saxena D, Miller G., Free PMC Article | 11/30/2019 |
| Our study provides comprehensive information regarding spatial and temporal expression of collectins (SP-A, SP-D and MBL-A) and their cellular sources in murine testis. Positive regulation by testosterone and alteration in their level upon LPS challenge are clues relevant to suggest their involvement in testicular immune privilege | Testicular expression of SP-A, SP-D and MBL-A is positively regulated by testosterone and modulated by lipopolysaccharide.
Rokade S, Madan T. | 12/2/2017 |
| this study shows that MBL-A expression is induced in the gut in response to Candida albicans sensing and is required for intestinal homeostasis and host defense against Candida albicans | Role of mannose-binding lectin in intestinal homeostasis and fungal elimination.
Choteau L, Parny M, François N, Bertin B, Fumery M, Dubuquoy L, Takahashi K, Colombel JF, Jouault T, Poulain D, Sendid B, Jawhara S. | 11/11/2017 |
| Targeted deletion of Mbl1/2 causes differential levels of inflammation-related gene sets at baseline and after exposure to ozone and significantly reduces pulmonary inflammation, thus indicating an important innate immunomodulatory role of the Mbl1/2 genes. | Effects of mannose-binding lectin on pulmonary gene expression and innate immune inflammatory response to ozone.
Ciencewicki JM, Verhein KC, Gerrish K, McCaw ZR, Li J, Bushel PR, Kleeberger SR., Free PMC Article | 05/27/2017 |
| Data indicate that lysyl hydroxylase 3 is essential for the glucosyltion of mannan-binding lectin MBL-A. | Lysyl hydroxylase 3 modifies lysine residues to facilitate oligomerization of mannan-binding lectin.
Risteli M, Ruotsalainen H, Bergmann U, Venkatraman Girija U, Wallis R, Myllylä R., Free PMC Article | 08/1/2015 |
| MBL deficiency in knockout mice reduces deposition of fibrin(ogen) in blood vessels of ischemic tissue and emphasizes a role for MBL in local thrombus formation during acute ischemia/reperfusion. | Mannose-binding lectin promotes local microvascular thrombosis after transient brain ischemia in mice.
de la Rosa X, Cervera A, Kristoffersen AK, Valdés CP, Varma HM, Justicia C, Durduran T, Chamorro Á, Planas AM. | 07/5/2014 |
| Data indicate that no change of mannan-binding lectin MBL-A during the study, however, mannan-binding lectin MBL-C concentration increased in median by 3.6-fold (2.9; 4.5-fold) during the study in the diabetic group. | Diabetes-induced changes in mannan-binding lectin levels and complement activation in a mouse model of type 1 diabetes.
Ostergaard JA, Bjerre M, Dagnaes-Hansen F, Hansen TK, Thiel S, Flyvbjerg A. | 05/18/2013 |
| Our data show an important role for MBL in the pathogenesis of brain ischemic injury and provide a strong support to the concept that MBL inhibition may be a relevant therapeutic target. | Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.
Orsini F, Villa P, Parrella S, Zangari R, Zanier ER, Gesuete R, Stravalaci M, Fumagalli S, Ottria R, Reina JJ, Paladini A, Micotti E, Ribeiro-Viana R, Rojo J, Pavlov VI, Stahl GL, Bernardi A, Gobbi M, De Simoni MG., Free PMC Article | 12/8/2012 |
| Mannan-binding lectin has a role in diabetic kidney disease | Mannan-binding lectin in diabetic kidney disease: the impact of mouse genetics in a type 1 diabetes model.
Østergaard JA, Bjerre M, RamachandraRao SP, Sharma K, Nyengaard JR, Hansen TK, Thiel S, Flyvbjerg A., Free PMC Article | 10/13/2012 |
| the binding of S-MBP to meprins triggers the complement activation through the lectin pathway and may cause the acute renal failure due to ischemia/reperfusion injury on kidney transplantation and hemorrhagic shock | Role of interaction of mannan-binding protein with meprins at the initial step of complement activation in ischemia/reperfusion injury to mouse kidney.
Hirano M, Ma BY, Kawasaki N, Oka S, Kawasaki T. | 03/31/2012 |
| MBL deficiency plays a potentially protective role in neutrophil-mediated cerebral injury after ischemia reperfusion. | The contribution of mannose binding lectin to reperfusion injury after ischemic stroke.
Morrison H, Frye J, Davis-Gorman G, Funk J, McDonagh P, Stahl G, Ritter L., Free PMC Article | 01/14/2012 |
| mediates blood coagulation, deficiency is a risk factor in developing disseminated intravascular coagulation | Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation.
Takahashi K, Chang WC, Takahashi M, Pavlov V, Ishida Y, La Bonte L, Shi L, Fujita T, Stahl GL, Van Cott EM., Free PMC Article | 07/23/2011 |
| Data show that genetically defined MBL-deficiency is associated with a better outcome after acute stroke. | Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke.
Cervera A, Planas AM, Justicia C, Urra X, Jensenius JC, Torres F, Lozano F, Chamorro A., Free PMC Article | 10/4/2010 |
| Recombinant mouse ficolin A, mannose-binding lectin-A, and mannose-binding lectin-C bound to fibrinogen in a dose-dependent manner. The lectin pathway, through mannose-binding lectins, synchronized with blood coagulation. | Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway.
Endo Y, Nakazawa N, Iwaki D, Takahashi M, Matsushita M, Fujita T. | 08/9/2010 |
| Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin-A and -C. | Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin.
Busche MN, Pavlov V, Takahashi K, Stahl GL., Free PMC Article | 01/21/2010 |
| MBL is abundantly present and locally produced during early atherogenesis | Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice.
Matthijsen RA, de Winther MP, Kuipers D, van der Made I, Weber C, Herias MV, Gijbels MJ, Buurman WA. | 01/21/2010 |
| MBL-A is not a necessary component for immunity to either T. muris or S. mansoni helminths, however, MBL-A appears to be necessary for the development of specific IgM responses to nematode antigens. | Altered antibody responses in mannose-binding lectin-A deficient mice do not affect Trichuris muris or Schistosoma mansoni infections.
Lawrence RA, Carter T, Bell LV, Else KJ, Summerfield J, Bickle Q. | 01/21/2010 |
| MBL deficiency increases susceptibility to controlled cortical impact through C3-independent mechanisms | Mannose binding lectin gene deficiency increases susceptibility to traumatic brain injury in mice.
Yager PH, You Z, Qin T, Kim HH, Takahashi K, Ezekowitz AB, Stahl GL, Carroll MC, Whalen MJ. | 01/21/2010 |
| Toll-like receptors 2 and 6 signaling from the phagosome is enhanced by mannose-binding lectin | Mannose-binding lectin enhances Toll-like receptors 2 and 6 signaling from the phagosome.
Ip WK, Takahashi K, Moore KJ, Stuart LM, Ezekowitz RA., Free PMC Article | 01/21/2010 |
| MBL has a pivotal role in the development of diabetic kidney disea | Mannose-binding lectin deficiency attenuates renal changes in a streptozotocin-induced model of type 1 diabetes in mice.
Østergaard J, Thiel S, Gadjeva M, Hansen TK, Rasch R, Flyvbjerg A. | 01/21/2010 |